Publications of Yvonne Genzel
All genres
Journal Article (105)
2021
Journal Article
, Chawla, A., , Kupke, S. Y., Genzel, Y., & Reichl, U. (2021)Cell culture–based production of defective interfering influenza A virus particles in perfusion mode using an alternating tangential flow filtration systemApplied Microbiology and Biotechnology, 105, 7251–7264doi: 10.1007/s00253-021-11561-y.
Journal Article
, , Marichal-Gallardo, P., , Benndorf, D., Genzel, Y., , Kupke, S. Y., & Reichl, U. (2021)OP7, a novel influenza A virus defective interfering particle: production, purification, and animal experiments demonstrating antiviral potentialApplied Microbiology and Biotechnology, 105 (1), 129–146doi: 10.1007/s00253-020-11029-5.
Journal Article
, , , , , , , , , , , Reichl, U., , Genzel, Y., & (2021)SARS-CoV-2 Production in a Scalable High Cell Density BioreactorVaccines, 9 (7), 706doi: 10.3390/vaccines9070706.
Journal Article
, Rehberg, M., Janke, R., , Genzel, Y., , , Rapp, E., & Reichl, U. (2021)Tracking changes in adaptation to suspension growth for MDCK cells: cell growth correlates with levels of metabolites, enzymes and proteinsApplied Microbiology and Biotechnology, 105 (5), 1861–1874doi: 10.1007/s00253-021-11150-z.
Journal Article
Pelz, L., Rüdiger, D., Dogra, T., , Genzel, Y., , Kupke, S. Y., & Reichl, U. (2021)Semi-continuous propagation of influenza A virus and its defective interfering particles: analyzing the dynamic competition to select candidates for antiviral therapyJournal of Virology, 95 (24), e01174-21doi: 10.1128/JVI.01174-21.
Journal Article
Pralow, A., Hoffmann, M., Nguyen-Khuong, T., Pioch, M., Hennig, R., Genzel, Y., Rapp, E., & Reichl, U. (2021)Comprehensive N‐glycosylation analysis of the influenza A virus proteins HA and NA from adherent and suspension MDCK cellsThe FEBS Journal, 288 (16), 4869–4891doi: 10.1111/febs.15787.
Journal Article
Pralow, A., Nikolay, A., , Genzel, Y., Rapp, E., & Reichl, U. (2021)Site-specific N-glycosylation analysis of animal cell culture-derived Zika virus proteinsScientific Reports, 11 (1), 5147doi: 10.1038/s41598-021-84682-z.
Journal Article
Wu, Y., Bissinger, T., Genzel, Y., , Reichl, U., & (2021)High cell density perfusion process for high yield of influenza A virus production using MDCK suspension cellsApplied Microbiology and Biotechnology, 105 (4), 1421–1434doi: 10.1007/s00253-020-11050-8.
2020
Journal Article
Coronel, J., Gränicher, G., , , Genzel, Y., & Reichl, U. (2020)Application of an Inclined Settler for Cell Culture-Based Influenza A Virus Production in Perfusion ModeFrontiers in Bioengineering and Biotechnology, 8, 672doi: 10.3389/fbioe.2020.00672.
Journal Article
Gränicher, G., Coronel, J., , , Genzel, Y., & Reichl, U. (2020)Performance of an Acoustic Settler Versus a Hollow Fiber-Based ATF Technology for Influenza Virus Production in PerfusionApplied Microbiology and Biotechnology, 104 (11), 4877–4888doi: 10.1007/s00253-020-10596-x.
Journal Article
Nikolay, A., , Genzel, Y., , & Reichl, U. (2020)Virus harvesting in perfusion culture: Choosing the right typeof hollow fiber membraneBiotechnology and Bioengineering, 117 (10), 3040–3052doi: 10.1002/bit.27470.
Journal Article
, , Laske, T., , , Genzel, Y., & (2020)Cell Bank Origin of MDCK Parental Cells Shapes Adaptation to Serum-Free Suspension Culture and Canine Adenoviral Vector ProductionInternational Journal of Molecular Sciences, 21 (17), 6111doi: 10.3390/ijms21176111.
Journal Article
Rodrigues Correia Ramos, J., Rath, A., Genzel, Y., , & Reichl, U. (2020)A dynamic model linking cell growth to intracellular metabolism and extracellular by‐product accumulationBiotechnology and Bioengineering, 117 (5), 1533–1553doi: 10.1002/bit.27288.
2019
Journal Article
Bissinger, T., Fritsch, J., Mihut, A. N., , , Genzel, Y., , & Reichl, U. (2019)Semi-perfusion cultures of suspension MDCK cells enable high cell concentrations and efficient influenza A virus productionVaccine, 37 (47), 7003–7010doi: 10.1016/j.vaccine.2019.04.054.
Journal Article
Coronel, J., Behrendt, I., , , , Reichl, U., & Genzel, Y. (2019)Influenza A virus production in a single-use orbital shaken bioreactor with ATF or TFF perfusion systemsVaccine, 37 (47), 7011–7018doi: 10.1016/j.vaccine.2019.06.005.
Journal Article
Fortuna, A. R., Van Teeffelen, S., , Fischer, L. M., , Genzel, Y., , , & Reichl, U. (2019)Use of sulfated cellulose membrane adsorbers for chromatographic purification of cell cultured-derived influenza A and B virusesSeparation and Purification Technology, (226), 350–358doi: 10.1016/j.seppur.2019.05.101.
Journal Article
Gränicher, G., Coronel, J., Pralow, A., Marichal-Gallardo, P., Wolff, M. W., Rapp, E., , , Genzel, Y., & Reichl, U. (2019)Efficient influenza A virus production in high cell density using the novel porcine suspension cell line PBG.PK2.1Vaccine, 37 (47), 7019–7028doi: 10.1016/j.vaccine.2019.04.030.
Journal Article
Tapia, F., Laske, T., Wasik, M., Rammhold, M., Genzel, Y., & Reichl, U. (2019)Production of Defective Interfering Particles of Influenza A Virus in Parallel Continuous Cultures at Two Residence Times—Insights From qPCR Measurements and Viral Dynamics ModelingFrontiers in Bioengineering and Biotechnology, 7, 275doi: 10.3389/fbioe.2019.00275.
Journal Article
Tapia, F., Wohlfahrt, D., , , Genzel, Y., & Reichl, U. (2019)Continuous influenza virus production in a tubular bioreactor system provides stable titers and avoids the “von Magnus effect”PLoS One, 14 (11), e0224317doi: 10.1371/journal.pone.0224317.
Journal Article
Vazquez-Ramirez, D., , , Genzel, Y., & Reichl, U. (2019)High titer MVA and influenza A virus production using a hybrid fed-batch/perfusion strategy with an ATF systemApplied Microbiology and Biotechnology, 103 (7), 3025–3035doi: 10.1007/s00253-019-09694-2.