Publications of Sascha Young Kupke

Journal Article (12)

2022
Journal Article
Küchler, J., Püttker, S., Lahmann, P., Genzel, Y., Kupke, S. Y., Benndorf, D., & Reichl, U. (2022)Absolute quantification of viral proteins during single-round replication of MDCK suspension cellsJournal of Proteomics, 259, 104544doi: 10.1016/j.jprot.2022.104544.
2021
Journal Article
Hein, M. D., Arora, P., Marichal-Gallardo, P., Winkler, M., Genzel, Y., Pöhlmann, S., Schughart, K., Kupke, S. Y., & Reichl, U. (2021)Cell culture-based production and in vivo characterization of purely clonal defective interfering influenza virus particlesBMC Biology, 19 (1), 91doi: 10.1186/s12915-021-01020-5.
Journal Article
Hein, M. D., Chawla, A., Cattaneo, M., Kupke, S. Y., Genzel, Y., & Reichl, U. (2021)Cell culture–based production of defective interfering influenza A virus particles in perfusion mode using an alternating tangential flow filtration systemApplied Microbiology and Biotechnology, 105, 7251–7264doi: 10.1007/s00253-021-11561-y.
Journal Article
Hein, M. D., Kollmus, H., Marichal-Gallardo, P., Püttker, S., Benndorf, D., Genzel, Y., Schughart, K., Kupke, S. Y., & Reichl, U. (2021)OP7, a novel influenza A virus defective interfering particle: production, purification, and animal experiments demonstrating antiviral potentialApplied Microbiology and Biotechnology, 105 (1), 129–146doi: 10.1007/s00253-020-11029-5.
Journal Article
Pelz, L., Rüdiger, D., Dogra, T., Alnaji, F. G., Genzel, Y., Brooke, C. B., Kupke, S. Y., & Reichl, U. (2021)Semi-continuous propagation of influenza A virus and its defective interfering particles: analyzing the dynamic competition to select candidates for antiviral therapyJournal of Virology, 95 (24), e01174-21doi: 10.1128/JVI.01174-21.
Journal Article
Rand, U., Kupke, S. Y., Shkarlet, H., Hein, M. D., Hirsch, T., Marichal-Gallardo, P., Cicin-Sain, L., Reichl, U., & Bruder, D. (2021)Antiviral Activity of Influenza A Virus Defective Interfering Particles against SARS-CoV-2 Replication In Vitro through Stimulation of Innate ImmunityCells, 10 (7), 1756doi: 10.3390/cells10071756.
Journal Article
Rüdiger, D., Pelz, L., Hein, M. D., Kupke, S. Y., & Reichl, U. (2021)Multiscale model of defective interfering particle replication for influenza A virus infection in animal cell culturePLoS Computational Biology, 17, e1009357doi: 10.1371/journal.pcbi.1009357.
2020
Journal Article
Kupke, S. Y., Ly, L.-H., Börno, S. T., Ruff, A., Timmermann, B., Vingron, M., Haas , S., & Reichl, U. (2020)Single-Cell Analysis Uncovers a Vast Diversity in Intracellular Viral Defective Interfering RNA Content Affecting the Large Cell-to-Cell Heterogeneity in Influenza A Virus ReplicationViruses, 12 (1), 71doi: 10.3390/v12010071.
2019
Journal Article
Kupke, S. Y., Riedel, D., Frensing, T., Zmora, P., & Reichl, U. (2019)A Novel Type of Influenza A Virus-Derived Defective Interfering Particle with Nucleotide Substitutions in Its GenomeJournal of Virology, 93 (4), 01786-18doi: 10.1128/JVI.01786-18.
Journal Article
Rüdiger, D., Kupke, S. Y., Laske, T., Zmora, P., & Reichl, U. (2019)Multiscale modeling of influenza A virus replication in cell cultures predicts infection dynamics for highly different infection conditionsPLoS Computational Biology, 15 (2), e1006819doi: 10.1371/journal.pcbi.1006819.
2016
Journal Article
Frensing, T., Kupke, S. Y., Bachmann, M., Fritzsche, S., Gallo Ramirez, L. E., & Reichl, U. (2016)Influenza virus intracellular replication dynamics, release kinetics, and particle morphology during propagation in MDCK cellsApplied Microbiology and Biotechnology, 100 (16), 7181–7192doi: 10.1007/s00253-016-7542-4.
2015
Journal Article
Heldt, F. S., Kupke, S. Y., Dorl, S., Frensing, T., & Reichl, U. (2015)Single-cell analysis and stochastic modelling unveil large cell-to-cell variability in influenza A virus infectionNature Communications, 6, 8938doi: 10.1038/ncomms9938.

Conference Paper (1)

2018
Conference Paper
Rüdiger, D., Kupke, S. Y., & Reichl, U. (2018)A multiscale model of influenza A virus replication covering highly different infection conditions in cell culturesIn: IFAC-PapersOnLine, 32–33doi: 10.1016/j.ifacol.2018.09.026.

Meeting Abstract (2)

2019
Meeting Abstract
Hein, M., Tapia, F., Genzel, Y., Kupke, S. Y., & Reichl, U. (2019)Continuous mode of production for two classes of defective interfering influenza A virus particles as antiviral candidatesIn: Integrated Continuous Biomanufacturing IV, 76.
2018
Meeting Abstract
Kupke, S. Y., Riedel, D., Frensing, T., Zmora, P., & Reichl, U. (2018)Single-cell analysis uncovers a novel influenza A virus-derived defective interfering particle for antiviral therapyIn: Vaccine Technology VII, 133.

Talk (16)

2022
Talk
Hein, M., Chawla, A., Arora , P., Cattaneo, M., Winkler, M., Pöhlmann, S., Schughart, K., Genzel, Y., Kupke, S. Y., & Reichl, U.Production of influenza A virus defective interfering particles in a high cell density perfusion cultivation with continuous virus harvestingPresented at: Vaccine Technology VIIISitges (Spain), June 12, 2022.
Talk
Hein, M., Dogra, T., Arora , P., Rand , U., Genzel, Y., Cattaneo, M., Winkler, M., Cicin-Sain, L., Bruder, D., Schughart, K., Pöhlmann, S., Kupke, S. Y., & Reichl, U.Influenza A Virus-Derived Defective Interfering Particles for Antiviral TreatmentPresented at: 27th ESACT MeetingLisbon (Portugal), June 26, 2022.
Talk
Kupke, S. Y., Hein, M. D., Bdeir, N., Rand, U., Marichal-Gallardo, P., Cicin-Sain, L., Bruder, D., Pöhlmann, S., Schughart, K., & Reichl, U.Influenza A Virus Defective Interfering Particles for Antiviral Treatment of the Influenza Disease and COVID-19Presented at: 31st Annual Meeting of the Society for Virologyonline, March 30, 2022.
Talk
Pelz, L., Rüdiger, D., Dogra, T., Alnaji, F. G., Genzel, Y., Brooke, C. B., Kupke, S. Y., & Reichl, U.Long-Term Propagation of Influenza A Virus and Its Defective Interfering Particles: Analyzing Dynamic Competition to Select Antiviral CandidatesPresented at: Vaccine Technology VIIISitges (Spain), June 12, 2022.
Talk
Pelz, L., Rüdiger, D., Dogra, T., Alnaji, F. G., Genzel, Y., Brooke, C. B., Kupke, S. Y., & Reichl, U.Semi-Continuous propagation of Influenza A virus and its defective interfering particles: Analyzing the dynamic competition to select antiviral candidatesPresented at: 27th ESACT MeetingLisbon (Portugal), June 26, 2022.
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