Publications of Tanja Laske

Rüdiger, D., Piasecka, J., Küchler, J., Pontes, C., Laske, T., Kupke, S. Y., & Reichl, U. (2024)Mathematical model calibrated to in vitro data predicts mechanisms of antiviral action of the influenza defective interfering particle “OP7”iScience, 27 (4), 109421doi: 10.1016/j.isci.2024.109421.

Duvigneau, S., Dürr, R., Laske, T., Bachmann, M., Dostert, M., & Kienle, A. (2020)Model-based approach for predicting the impact of genetic modifications on product yield in biopharmaceutical manufacturing—Application to influenza vaccine productionPLoS Computational Biology, 16 (6), e1007810doi: 10.1371/journal.pcbi.1007810.

Rodrigues, A. F., Fernandes, P., Laske, T., Castro, R., Marques Alves, P., Genzel, Y., & Coroadinha, A. S. (2020)Cell Bank Origin of MDCK Parental Cells Shapes Adaptation to Serum-Free Suspension Culture and Canine Adenoviral Vector ProductionInternational Journal of Molecular Sciences, 21 (17), 6111doi: 10.3390/ijms21176111.

Laske, T., Bachmann, M., Dostert, M., Karlas, A., Wirth, D., Frensing, T., Meyer, T. F., Hauser, H., & Reichl, U. (2019)Model-based analysis of influenza A virus replication in genetically engineered cell lines elucidates the impact of host cell factors on key kinetic parameters of virus growthPLoS Computational Biology, 15 (4), e1006944doi: 10.1371/journal.pcbi.1006944.

Rüdiger, D., Kupke, S. Y., Laske, T., Zmora, P., & Reichl, U. (2019)Multiscale modeling of influenza A virus replication in cell cultures predicts infection dynamics for highly different infection conditionsPLoS Computational Biology, 15 (2), e1006819doi: 10.1371/journal.pcbi.1006819.

Tapia, F., Laske, T., Wasik, M., Rammhold, M., Genzel, Y., & Reichl, U. (2019)Production of Defective Interfering Particles of Influenza A Virus in Parallel Continuous Cultures at Two Residence Times—Insights From qPCR Measurements and Viral Dynamics ModelingFrontiers in Bioengineering and Biotechnology, 7, 275doi: 10.3389/fbioe.2019.00275.

Laske, T., Heldt, S., Hoffmann, H., Frensing, T., & Reichl, U. (2016)Reprint of “Modeling the intracellular replication of influenza A virus in the presence of defective interfering RNAsVirus Research, 218, 86–95doi: 10.1016/j.virusres.2016.05.009.

Castro, R., Fernandes, P., Laske, T., Sousa, M. F. Q., Genzel, Y., Scharfenberg, K., Alves, P. M., & Coroadinha, A. S. (2015)Production of canine adenovirus type 2 in serum-free suspension cultures of MDCK cellsApplied Microbiology and Biotechnology, 99 (17), 7059–7068doi: 10.1007/s00253-015-6636-8.

Peschel, B., Frentzel, S., Laske, T., Genzel, Y., & Reichl, U. (2013)Comparison of influenza virus yields and apoptosis-induction in an adherent and a suspension MDCK cell lineVaccine, 31 (48), 5693–5699doi: 10.1016/j.vaccine.2013.09.051.

Duvigneau, S., Dürr, R., Laske, T., Bachmann, M., Dostert, M., Reichl, U., & Kienle, A. (2018)Mathematical modeling as a tool to improve influenza vaccine production processesIn: IFAC-PapersOnLine, 1–4doi: 10.1016/j.ifacol.2018.09.004.

Dürr, R., Duvigneau, S., Laske, T., Bachmann, M., & Kienle, A. (2016)Analyzing the Impact of Heterogeneity in Genetically Engineered Cell Lines for Influenza Vaccine Production Using Population Balance ModelingIn: IFAC-PapersOnLine, 225–230doi: 10.1016/j.ifacol.2016.12.130.

Fernandes, P., Castro, R., Laske, T., Genzel, Y., Kremer, E., Alves, P., & Coroadinha, A. (2014)The impact of MDCK cell source on the production of influenza and canine adenovirusIn: New Biotechnology: Abstracts of the 16th European Congress on Biotechnology, S180doi: 10.1016/j.nbt.2014.05.907.

Laske, T., Tapia, F., Wasik, M., Rammhold, M., Genzel, Y., & Reichl, U.Production of defective interfering particles of influenza A virus in continuously cultured bioreactors at two residence times - insights from within-host virus dynamicsPresented at: 4th Workshop on Viral DynamicsParis, France, October 21, 2019.

Rüdiger, D., Laske, T., Kupke, S. Y., & Reichl, U.Multiscale model of DIP interference and production during influenza A virus infection in animal cell culturePresented at: 4th Workshop on Virus DynamicsParis, France, October 21, 2019.

Duvigneau, S., Dürr, R., Laske, T., Bachmann, M., Dostert, M., Reichl, U., & Kienle, A.Mathematical modeling as a tool to improve influenza vaccine production processesPresented at: FOSBE 2018Chicago, Illinois, USA, August 5, 2018.

Laske, T., Bachmann, M., Dostert, M., Karlas, A., Wirth, D., Frensing, T., & Reichl, U.Model-based characterization of influenza A virus production in genetically engineered cell lines elucidates changes in virus replicationPresented at: 3rd Workshop on Virus DynamicsHeidelberg, Germany, October 6, 2017.

Laske, T., Bachmann, M., Frensing, T., & Reichl, U.Model-based analysis of influenza A virus replication in genetically modified cell lines elucidates virus-host cell interactionsPresented at: 1st ESACT Frontiers RetreatLyon, France, October 20, 2016.

Laske, T., Heldt, F. S., Frensing, T., & Reichl, U.Analyzing the dynamics of influenza A virus replication in the presence of defective interfering RNAsPresented at: 2nd Workshop on Virus Dynamics Toronto, Ontario, Canada, July 17, 2015.

Laske, T.Mathematical modeling of virus-host cell interactions during influenza virus replication supports cell line development for vaccine productionPresented at: Workshop on Virus Dynamics and Evolution des Centre De Recerca Matemàtica (CRM)Bellaterra, Spain, June 30, 2014.

Rüdiger, D., Laske, T., Kupke, S. Y., & Reichl, U.A multiscale model of defective interfering particle replicationPresented at: FOSBE 2019Valencia, Spain, October 15, 2019.