Publications of Frank Stefan Heldt

Laske, T., Heldt, F. S., Hoffmann, H., Frensing, T., & Reichl, U. (2016)Modeling the intracellular replication of influenza A virus in the presence of defective interfering RNAsVirus Research, 213, 90–99doi: 10.1016/j.virusres.2015.11.016.

Laske, T., Heldt, S., Hoffmann, H., Frensing, T., & Reichl, U. (2016)Reprint of “Modeling the intracellular replication of influenza A virus in the presence of defective interfering RNAsVirus Research, 218, 86–95doi: 10.1016/j.virusres.2016.05.009.

Heldt, F. S., Kupke, S. Y., Dorl, S., Frensing, T., & Reichl, U. (2015)Single-cell analysis and stochastic modelling unveil large cell-to-cell variability in influenza A virus infectionNature Communications, 6, 8938doi: 10.1038/ncomms9938.

Frensing, T., Heldt, S., Pflugmacher, A., Behrendt, I., Jordan, I., Flockerzi, D., Genzel, Y., & Reichl, U. (2013)Continuous Influenza Virus Production in Cell Culture Shows a Periodic Accumulation of Defective Interfering ParticlesPLoS One, 8 (9), e72288doi: 10.1371/journal.pone.0072288.

Heldt, S., Frensing, T., Pflugmacher, A., Gröpler, R., Peschel, B., & Reichl, U. (2013)Multiscale Modeling of Influenza A Virus Infection Supports the Development of Direct-Acting AntiviralsPLoS Computational Biology, 9 (11), e1003372doi: 10.1371/journal.pcbi.1003372.

Heldt, F. S., Frensing, T., & Reichl, U. (2012)Modeling the intracellular dynamics of influenza virus replication to understand the control of viral RNA synthesisJournal of Virology, 86 (15), 7806–7817doi: 10.1128/JVI.00080-12.

Vester, D., Pflugmacher, A., Hoffmann, D., Seitz, C., Heldt, S., Bettenbrock, K., Genzel, Y., & Reichl, U. (2010)Real-time RT-qPCR assay for the analysis of human influenza A virus transcription and replication dynamicsJournal of Virological Methods, 168 (1-2), 63–71doi: 10.1016/j.jviromet.2010.04.017.

Kupke, S. Y., Heldt, S., Frensing, T., & Reichl, U.Single-Cell Analysis of Influenza A Virus-Infected CellsPresented at: 26th Annual Meeting of the Society for VirologyMünster, Germany, July 7, 2016.

Kupke, S. Y., Heldt, S., Frensing, T., & Reichl, U.Heterogeneity in Influenza A Virus Infection Unveiled by Single-Cell Analysis and Stochastic Mathemeatical ModelingPresented at: Single Cell Technologies 2016Frankfurt/Main, April 6, 2016.

Kupke, S. Y., Heldt, S., Frensing, T., & Reichl, U.Single-Cell Analysis of Influenza A Virus-Infected Cells for the Optimization of Cell Culture-Based Vaccine ProductionPresented at: Vaccine Technology VIAlbufeira, Portugal, June 12, 2016.

Laske, T., Heldt, F. S., Frensing, T., & Reichl, U.Analyzing the dynamics of influenza A virus replication in the presence of defective interfering RNAsPresented at: 2nd Workshop on Virus Dynamics Toronto, Ontario, Canada, July 17, 2015.

Heldt, S., Frensing, T., & Reichl, U.The multiscale nature of influenza A virus infection and its implications for modeling antiviral therapyPresented at: The Joint Annual Meeting of the Japanese Society for Mathematical Biology and the Society for Mathematical BiologyOsaka, Japan, July 28, 2014.

Heldt, S., Isken, B., Pflugmacher, A., Frensing, T., & Reichl, U.Multi-scale modeling of influenza virus infection elucidates the performance of antiviralsPresented at: 1st Workshop on Virus Dynamics (DECHEMA)Frankfurt/Main, Germany, July 15, 2013.

Heldt, S., Peschel, B., Frensing, T., & Reichl, U.Multiscale modeling of influenza virus infection supports the development of antiviral drugsPresented at: 14th International Conference on Systems Biology Copenhagen (Denmark), August 30, 2013.

Heldt, F. S., Frensing, T., & Reichl, U.Elucidating bottlenecks in influenza virus replication to optimize vaccine productionPresented at: International Conference on the Systems Biology of Human DiseaseHeidelberg, Germany, May 2, 2012.

Heldt, F. S. & Reichl, U.Understanding the dynamics of intracellular virus replication - How does Influenza control its RNA and protein synthesis?Presented at: 4th ESWI Influenza ConferenceMalta, September 11, 2011.

Laske, T., Heldt, F. S., Hoffmann, H., Frensing, T., & Reichl, U.Modeling the intracellular replication of influenza A virus in the presence of defective interfering RNAsPresented at: 26th Annual Meeting of the Society for VirologyMünster, Germany, April 6, 2016.

Rüdiger, D., Heldt, S., Kupke, S. Y., & Reichl, U.Stochastic multiscale modeling of influenza virus production in cell cultures. Poster presented at 6th IFAC Conference on Foundations of Systems Biology in EngineeringPresented at: 6th IFAC Conference on Foundations of Systems Biology in Engineering (FOSBE)Magdeburg, Germany, October 9, 2016.

Rüdiger, D., Heldt, S., Kupke, S. Y., & Reichl, U.Stochastic multiscale modeling of influenza virus production in cell culturesPresented at: 6th IFAC Conference on Foundations of Systems Biology in Engineering (FOSBE)Magdeburg, Germany, October 9, 2016.

Kupke, S. Y., Heldt, F. S., Frensing, T., & Reichl, U.Single Cell Analysis of Influenza A Virus-infected Cells for the Optimization of Cell Culture-based Vaccine Manufacturing ProcessesPresented at: ESACT 2015Barcelona, Spain, May 31, 2015.