Publications of Yvonne Genzel

Journal Article (94)

2022
Journal Article
Göbel, S., Kortum, F., Chavez, K. J., Jordan, I., Sandig, V., Reichl, U., Altomonte, J., & Genzel, Y. (2022)Cell-line screening and process development for a fusogenic oncolytic virus in small-scale suspension culturesApplied Microbiology and Biotechnology, 106, 4945–4961doi: 10.1007/s00253-022-12027-5.
Journal Article
Küchler, J., Püttker, S., Lahmann, P., Genzel, Y., Kupke, S. Y., Benndorf, D., & Reichl, U. (2022)Absolute quantification of viral proteins during single-round replication of MDCK suspension cellsJournal of Proteomics, 259, 104544doi: 10.1016/j.jprot.2022.104544.
Journal Article
Möckel, M., Baldok, N., Walles, T., Hartig, R., Müller, A. J., Reichl, U., Genzel, Y., Walles, H., & Wiese-Rischke, C. (2022)Human 3D Airway Tissue Models for Real-Time Microscopy: Visualizing Respiratory Virus SpreadingCells, 11 (22), 3634doi: 10.3390/cells11223634.
Journal Article
Offersgaard, A., Duarte Hernandez, C. R., Pihl, A. F., Venkatesan, N. P., Krarup, H., Lin, X., Reichl, U., Bukh, J., Genzel, Y., & Gottwein, J. M. (2022)High-Titer Hepatitis C Virus Production in a Scalable Single-Use High Cell Density BioreactorVaccines, 10 (2), 249doi: 10.3390/vaccines10020249.
Journal Article
Rodrigues Correia Ramos, J., Bissinger, T., Genzel, Y., & Reichl, U. (2022)Impact of Influenza A Virus Infection on Growth and Metabolism of Suspension MDCK Cells Using a Dynamic ModelMetabolites, 12 (3), 239doi: 10.3390/metabo12030239.
2021
Journal Article
Bissinger, T., Wu, Y., Marichal-Gallardo, P., Riedel, D., Liu, X., Genzel, Y., Tan, W. S., & Reichl, U. (2021)Towards integrated production of an influenza A vaccine candidate with MDCK suspension cellsBiotechnology and Bioengineering, 118 (10), 3996–4013doi: 10.1002/bit.27876.
Journal Article
Gränicher, G., Babakhani, M., Göbel, S., Jordan, I., Marichal-Gallardo, P., Genzel, Y., & Reichl, U. (2021)A high cell density perfusion process for Modified Vaccinia virus Ankara production: process integration with inline DNA digestion and cost analysisBiotechnology and Bioengineering, 118 (12), 4720–4734doi: 10.1002/bit.27937.
Journal Article
Gränicher, G., Tapia, F., Behrendt, I., Jordan, I., Genzel, Y., & Reichl, U. (2021)Production of Modified Vaccinia Ankara Virus by Intensified Cell Cultures: A Comparison of Platform Technologies for Viral Vector ProductionBiotechnology Journal, 16 (1), e2000024doi: 10.1002/biot.202000024.
Journal Article
Hein, M. D., Arora, P., Marichal-Gallardo, P., Winkler, M., Genzel, Y., Pöhlmann, S., Schughart, K., Kupke, S. Y., & Reichl, U. (2021)Cell culture-based production and in vivo characterization of purely clonal defective interfering influenza virus particlesBMC Biology, 19 (1), 91doi: 10.1186/s12915-021-01020-5.
Journal Article
Hein, M. D., Chawla, A., Cattaneo, M., Kupke, S. Y., Genzel, Y., & Reichl, U. (2021)Cell culture–based production of defective interfering influenza A virus particles in perfusion mode using an alternating tangential flow filtration systemApplied Microbiology and Biotechnology, 105, 7251–7264doi: 10.1007/s00253-021-11561-y.
Journal Article
Hein, M. D., Kollmus, H., Marichal-Gallardo, P., Püttker, S., Benndorf, D., Genzel, Y., Schughart, K., Kupke, S. Y., & Reichl, U. (2021)OP7, a novel influenza A virus defective interfering particle: production, purification, and animal experiments demonstrating antiviral potentialApplied Microbiology and Biotechnology, 105 (1), 129–146doi: 10.1007/s00253-020-11029-5.
Journal Article
Offersgaard, A., Duarte Hernandez, C. R., Pihl, A. F., Costa, R., Venkatesan, N. P., Lin, X., Van Pham, L., Feng, S., Fahnøe, U., Scheel, T. K. H., Ramirez, S., Reichl, U., Bukh, J., Genzel, Y., & Gottwein, J. M. (2021)SARS-CoV-2 Production in a Scalable High Cell Density BioreactorVaccines, 9 (7), 706doi: 10.3390/vaccines9070706.
Journal Article
Pech, S., Rehberg, M., Janke, R., Benndorf, D., Genzel, Y., Muth, T., Sickmann, A., Rapp, E., & Reichl, U. (2021)Tracking changes in adaptation to suspension growth for MDCK cells: cell growth correlates with levels of metabolites, enzymes and proteinsApplied Microbiology and Biotechnology, 105 (5), 1861–1874doi: 10.1007/s00253-021-11150-z.
Journal Article
Pelz, L., Rüdiger, D., Dogra, T., Alnaji, F. G., Genzel, Y., Brooke, C. B., Kupke, S. Y., & Reichl, U. (2021)Semi-continuous propagation of influenza A virus and its defective interfering particles: analyzing the dynamic competition to select candidates for antiviral therapyJournal of Virology, 95 (24), e01174-21doi: 10.1128/JVI.01174-21.
Journal Article
Pralow, A., Hoffmann, M., Nguyen-Khuong, T., Pioch, M., Hennig, R., Genzel, Y., Rapp, E., & Reichl, U. (2021)Comprehensive N‐glycosylation analysis of the influenza A virus proteins HA and NA from adherent and suspension MDCK cellsThe FEBS Journal, 288 (16), 4869–4891doi: 10.1111/febs.15787.
Journal Article
Pralow, A., Nikolay, A., Leon, A., Genzel, Y., Rapp, E., & Reichl, U. (2021)Site-specific N-glycosylation analysis of animal cell culture-derived Zika virus proteinsScientific Reports, 11 (1), 5147doi: 10.1038/s41598-021-84682-z.
Journal Article
Wu, Y., Bissinger, T., Genzel, Y., Liu, X., Reichl, U., & Tan, W.-S. (2021)High cell density perfusion process for high yield of influenza A virus production using MDCK suspension cellsApplied Microbiology and Biotechnology, 105 (4), 1421–1434doi: 10.1007/s00253-020-11050-8.
2020
Journal Article
Coronel, J., Gränicher, G., Sandig, V., Noll, T., Genzel, Y., & Reichl, U. (2020)Application of an Inclined Settler for Cell Culture-Based Influenza A Virus Production in Perfusion ModeFrontiers in Bioengineering and Biotechnology, 8, 672doi: 10.3389/fbioe.2020.00672.
Journal Article
Gränicher, G., Coronel, J., Trampler, F., Jordan, I., Genzel, Y., & Reichl, U. (2020)Performance of an Acoustic Settler Versus a Hollow Fiber-Based ATF Technology for Influenza Virus Production in PerfusionApplied Microbiology and Biotechnology, 104 (11), 4877–4888doi: 10.1007/s00253-020-10596-x.
Journal Article
Nikolay, A., de Grooth, J., Genzel, Y., Wood, J. A., & Reichl, U. (2020)Virus harvesting in perfusion culture: Choosing the right typeof hollow fiber membraneBiotechnology and Bioengineering, 117 (10), 3040–3052doi: 10.1002/bit.27470.
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