Publications of Pavel Marichal-Gallardo

Journal Article (9)

2021
Journal Article
Bissinger, T., Wu, Y., Marichal-Gallardo, P., Riedel, D., Liu, X., Genzel, Y., Tan, W. S., & Reichl, U. (2021)Towards integrated production of an influenza A vaccine candidate with MDCK suspension cellsBiotechnology and Bioengineering, 118 (10), 3996–4013doi: 10.1002/bit.27876.
Journal Article
Gränicher, G., Babakhani, M., Göbel, S., Jordan, I., Marichal-Gallardo, P., Genzel, Y., & Reichl, U. (2021)A high cell density perfusion process for Modified Vaccinia virus Ankara production: process integration with inline DNA digestion and cost analysisBiotechnology and Bioengineering, 118 (12), 4720–4734doi: 10.1002/bit.27937.
Journal Article
Hein, M. D., Arora, P., Marichal-Gallardo, P., Winkler, M., Genzel, Y., Pöhlmann, S., Schughart, K., Kupke, S. Y., & Reichl, U. (2021)Cell culture-based production and in vivo characterization of purely clonal defective interfering influenza virus particlesBMC Biology, 19 (1), 91doi: 10.1186/s12915-021-01020-5.
Journal Article
Hein, M. D., Kollmus, H., Marichal-Gallardo, P., Püttker, S., Benndorf, D., Genzel, Y., Schughart, K., Kupke, S. Y., & Reichl, U. (2021)OP7, a novel influenza A virus defective interfering particle: production, purification, and animal experiments demonstrating antiviral potentialApplied Microbiology and Biotechnology, 105 (1), 129–146doi: 10.1007/s00253-020-11029-5.
Journal Article
Mahour, R., Marichal-Gallardo, P., Rexer, T., & Reichl, U. (2021)Multi-enzyme cascades for the in vitro synthesis of guanosine diphosphate L-fucoseChemCatChem, 13 (8), 1981–1989doi: 10.1002/cctc.202001854.
Journal Article
Marichal-Gallardo, P., Börner, K., Pieler, M., Sonntag-Buck, V., Obr, M., Bejarano, D., Wolff, M. W., Kräusslich, H.-G., Reichl, U., & Grimm, D. (2021)Single-use capture purification of adeno-associated viral gene transfer vectors by membrane-based steric exclusion chromatographyHuman Gene Therapy, 32 (17-18), 959–974doi: 10.1089/hum.2019.284 .
Journal Article
Rand, U., Kupke, S. Y., Shkarlet, H., Hein, M. D., Hirsch, T., Marichal-Gallardo, P., Cicin-Sain, L., Reichl, U., & Bruder, D. (2021)Antiviral Activity of Influenza A Virus Defective Interfering Particles against SARS-CoV-2 Replication In Vitro through Stimulation of Innate ImmunityCells, 10 (7), 1756doi: 10.3390/cells10071756.
2019
Journal Article
Gränicher, G., Coronel, J., Pralow, A., Marichal-Gallardo, P., Wolff, M. W., Rapp, E., Karlas, A., Sandig, V., Genzel, Y., & Reichl, U. (2019)Efficient influenza A virus production in high cell density using the novel porcine suspension cell line PBG.PK2.1Vaccine, 37 (47), 7019–7028doi: 10.1016/j.vaccine.2019.04.030.
2017
Journal Article
Marichal-Gallardo, P., Pieler, M., Wolff, M. W., & Reichl, U. (2017)Steric exclusion chromatography for purification of cell culture-derived influenza A virus using regenerated cellulose membranes and polyethylene glycolJournal of Chromatography A, 1483 (3), 110–119doi: 10.1016/j.chroma.2016.12.076.

Meeting Abstract (2)

2019
Meeting Abstract
Marichal-Gallardo, P., Genzel, Y., Börner, K., Grimm, D., Wolff, M. W., & Reichl, U. (2019)A single-use chromatographic purification platform for viral gene transfer vectors & viral vaccinesIn: Proceedings Advancing Manufacture of Cell and Gene Therapies VI, 92.
2018
Meeting Abstract
Marichal-Gallardo, P., Fortuna, A. R., Genzel, Y., Wolff, M. W., & Reichl, U. (2018)Purifying viruses with a sheet of paper: Single-use steric exclusion chromatography as a capture platform for vaccine candidatesIn: Vaccine Technology VII, 128.

Talk (9)

2022
Talk
Gränicher, G., Göbel, S., Marichal-Gallardo, P., Jordan, I., Sandig, V., Genzel, Y., & Reichl, U.Integrated cell-culture based MVA virus production process with perfusion mode for vaccines or gene therapyPresented at: Value through intensified bioprocessing IIOxford, United Kingdom, June 22, 2022.
Talk
Gränicher, G., Göbel, S., Marichal-Gallardo, P., Jordan, I., Sandig, V., Genzel, Y., & Reichl, U.Integrated cell-culture based MVA virus production process with perfusion mode for vaccines or gene therapyPresented at: 27th ESACT MeetingLisbon (Portugal), June 26, 2022.
Talk
Kupke, S. Y., Hein, M. D., Bdeir, N., Rand, U., Marichal-Gallardo, P., Cicin-Sain, L., Bruder, D., Pöhlmann, S., Schughart, K., & Reichl, U.Influenza A Virus Defective Interfering Particles for Antiviral Treatment of the Influenza Disease and COVID-19Presented at: 31st Annual Meeting of the Society for Virologyonline, March 30, 2022.
2019
Talk
Marichal-Gallardo, P., Genzel, Y., Börner, K., Grimm, D., Wolff, M. W., & Reichl, U.A single-use chromatographic purification platform for viral gene transfer vectors & viral vaccinesPresented at: ECI Advancing Manufacture of Cell and Gene Therapies VICoronado, United States of America, January 27, 2019.
Talk
Nikolay, A., Tapia, F., Marichal-Gallardo, P., Pralow, A., Hoffmann, M., Rapp, E., Genzel, Y., & Reichl, U.Moderne Methoden der ImpfstoffherstellungPresented at: Wissenschaft im RathausMagdeburg, Germany, September 30, 2019.
Talk
Nikolay, A., Tapia, F., Marichal-Gallardo, P., Pralow, A., Hoffmann, M., Rapp, E., Genzel, Y., & Reichl, U.Cell Culture-based Viral Vaccines: Process Intensification and MonitoringPresented at: Cuba Symposium “Frontiers of Science”Havanna, Cuba, March 5, 2019.
Talk
Tapia, F., Marichal-Gallardo, P., & Reichl, U.A universal platform for continuous manufacturing of viral vaccines & gene therapy vectorsPresented at: Workshop BioverfahrenstechnikLeuna, Germany, September 19, 2019.
2018
Talk
Marichal-Gallardo, P., Genzel, Y., Börner, K., Grimm, D., Wolff, M. W., & Reichl, U.A single-use purification platform for viral vaccines & gene therapy vectorsPresented at: International Symposium on the Separation of Proteins, Peptides, and Polynucleotides (ISPPP) 2018Berlin, Germany, November 3, 2018.
Talk
Marichal-Gallardo, P., Lothert, K., Grein, T., Reichl, U., Czermak, P., & Wolff, M. W.Single-use purification of cell culture-based virus particles by steric exclusion chromatographyPresented at: National Meeting of the American Chemical Society (ACS)New Orleans, USA, March 18, 2018.
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