Research Group: Analysis and Redesign of Biological Networks
Our research lies at the intersection of (micro)biology, informatics, mathematics and engineering sciences. We develop and apply methods from systems and computational biology and combine dry-lab and wet-lab investigations to analyze and rationally modify cellular (biomolecular) networks.
One central research direction is methods and tools for modeling and computational design of metabolic networks and their use to engineer microbial cell factories for biotechnological applications. Other important research areas include analysis of microbial communities, the optimization of cell-free production systems, and the model-driven investigation of fundamental metabolic and regulatory processes in bacteria. Theoretical investigations are combined with wet-lab experiments based on various genetic engineering and bioreactor cultivation techniques to verify model predictions and to study major aspects of the pyhsiology of microorganisms with focus on the model organism E. coli.
A long-term vision of the ARB group is to help pave the way for routine use of advanced mathematical modeling approaches in (micro)biology and biotechnology.
A detailed description of our research activities can be found here.
Keywords: Systems biology, Computational biology, Bioinformatics, Metabolic engineering, Systems biotechnology, Metabolic networks, Gene regulatory and signaling networks, Escherichia coli