Publications of Mandy Bachmann

Duvigneau, S., Dürr, R., Laske, T., Bachmann, M., Dostert, M., & Kienle, A. (2020)Model-based approach for predicting the impact of genetic modifications on product yield in biopharmaceutical manufacturing—Application to influenza vaccine productionPLoS Computational Biology, 16 (6), e1007810doi: 10.1371/journal.pcbi.1007810.

Laske, T., Bachmann, M., Dostert, M., Karlas, A., Wirth, D., Frensing, T., Meyer, T. F., Hauser, H., & Reichl, U. (2019)Model-based analysis of influenza A virus replication in genetically engineered cell lines elucidates the impact of host cell factors on key kinetic parameters of virus growthPLoS Computational Biology, 15 (4), e1006944doi: 10.1371/journal.pcbi.1006944.

Bachmann, M., Breitwieser, T., Lipps, C., Wirth, D., Jordan, I., Reichl, U., & Frensing, T. (2016)Impaired antiviral response of adenovirus-transformed cell lines supports virus replicationJournal of General Virology, 97 (2), 293–298doi: 10.1099/jgv.0.000361.

Frensing, T., Kupke, S. Y., Bachmann, M., Fritzsche, S., Gallo Ramirez, L. E., & Reichl, U. (2016)Influenza virus intracellular replication dynamics, release kinetics, and particle morphology during propagation in MDCK cellsApplied Microbiology and Biotechnology, 100 (16), 7181–7192doi: 10.1007/s00253-016-7542-4.

Duvigneau, S., Dürr, R., Laske, T., Bachmann, M., Dostert, M., Reichl, U., & Kienle, A. (2018)Mathematical modeling as a tool to improve influenza vaccine production processesIn: IFAC-PapersOnLine, 1–4doi: 10.1016/j.ifacol.2018.09.004.

Dürr, R., Duvigneau, S., Laske, T., Bachmann, M., & Kienle, A. (2016)Analyzing the Impact of Heterogeneity in Genetically Engineered Cell Lines for Influenza Vaccine Production Using Population Balance ModelingIn: IFAC-PapersOnLine, 225–230doi: 10.1016/j.ifacol.2016.12.130.

Duvigneau, S., Dürr, R., Laske, T., Bachmann, M., Dostert, M., Reichl, U., & Kienle, A.Mathematical modeling as a tool to improve influenza vaccine production processesPresented at: FOSBE 2018Chicago, Illinois, USA, August 5, 2018.

Laske, T., Bachmann, M., Dostert, M., Karlas, A., Wirth, D., Frensing, T., & Reichl, U.Model-based characterization of influenza A virus production in genetically engineered cell lines elucidates changes in virus replicationPresented at: 3rd Workshop on Virus DynamicsHeidelberg, Germany, October 6, 2017.

Laske, T., Bachmann, M., Frensing, T., & Reichl, U.Model-based analysis of influenza A virus replication in genetically modified cell lines elucidates virus-host cell interactionsPresented at: 1st ESACT Frontiers RetreatLyon, France, October 20, 2016.

Laske, T., Bachmann, M., Dostert, M., Frensing, T., Karlas, A., Wirth, D., & Reichl, U.Modeling reveals changes in key parameters of infuenza A virus replication in engineered cell linesPresented at: 11th Annual International Conference on Systems Biology of Human DiseasesLos Angeles, USA, June 4, 2018.

Dürr, R., Duvigneau, S., Laske, T., Bachmann, M., & Kienle, A.Analyzing the impact of heterogeneity in genetically engineered cell lines for influenza vaccine production using population balance modelingPresented at: 6th IFAC Conference on Foundations of Systems Biology in Engineering (FOSBE)Magdeburg, Germany, October 9, 2016.

Laske, T., Bachmann, M., Frensing, T., & Reichl, U.Model-based analysis of influenza A virus replication in genetically modified cell lines elucidates virus-host cell interactionsPresented at: 17th International Conference on Systems Biology (ICSB)Barcelona, Spain, September 16, 2016.

Bachmann, M., Breitwieser, T., Lipps , C., Wirth, D., Jordan, I., Rose, T., Sandig, V., Reichl, U., & Frensing, T.Impaired antiviral response supports viral vaccine production in adenoviral transformed designer cell linesPresented at: 25th Annual Meeting of the Society for VirologyBochum, Germany, March 18, 2015.

Bachmann, M., Breitwieser, T., Lipps, C., Wirth, D., Jordan, I., Rose, T., Sandig, V., Reichl, U., & Frensing, T.Impaired antiviral response supports influenza vaccine production in adenoviral transformed designer cell linesPresented at: ESACTBarcelona, May 31, 2015.

Bachmann, M., Frensing, T., Sandig, V., & Reichl, U.Expression of adenoviral early-region E1A protein benefits cell culture-based influenza vaccine productionPresented at: 4th International Influenza MeetingMünster, Germany, September 21, 2014.

Frensing, T., Heldt, S., Bachmann, M., Genzel, Y., Jordan, I., & Reichl, U.CONTINUOUS INFLUENZA VACCINE PRODUCTIONPresented at: Vaccine Technology 2014Playa del Carmen, Mexico, June 8, 2014.

Frensing, T., Heldt, S., Bachmann, M., Genzel, Y., Jordan, I., & Reichl, U.Continuous influenza vaccine productionPresented at: ProcessNet-Jahrestagung und 31. DECHEMA-Jahrestagung der Biotechnologen 2014Aachen, Germany, September 30, 2014.

Bachmann, M. (2019)Charakterisierung der Influenzavirus-Vermehrung in genetisch veränderten humanen Zelllinien zur Optimierung der ImpfstoffproduktionPhD Thesis, Otto-von-Guericke-Universität, Magdeburgdoi: 10.25673/26427.