Publications of Sascha Young Kupke

Kupke, S. Y., Riedel, D., Frensing, T., Zmora, P., & Reichl, U. (2018)Single-cell analysis uncovers a novel influenza A virus-derived defective interfering particle for antiviral therapyIn: Vaccine Technology VII, 133.

Pelz, L., Dogra, T., Piasecka, J., Rüdiger, D., Bälkner, M., Boehme, J. D., Kershaw, O., Volckmar, J., Genzel, Y., Bruder, D., Kupke, S. Y., & Reichl, U.Influenza Vector-Based Defective Interfering Particles for Use as Broad-Spectrum Antiviral and Mucosal Live Vaccine: Construction, Production and in Vivo EfficacyPresented at: 34^th Annual Meeting of the Society for VirologyHamburg (Germany), March 4, 2025.

Pelz, L., Dogra, T., Piasecka, J., Rüdiger, D., Bälkner, M., Boehme, J. D., Volckmar, J., Bruder, D., Kupke, S. Y., & Reichl, U.Engineered influenza vectors for use as broadly-acting antivirals and live nasal vaccines: design, manufacture and in vivo efficacyPresented at: 9^th European Congress of Virology (ECV)Cavtat/Dubrovnik (Croatia), April 27, 2025.

Pelz, L., Rüdiger, D., Hein, M., Böhme, J., Bälkner, M., Kershaw, O., Marichal-Gallardo, P., Gruber, A., Genzel, Y., Bruder, D., Kupke, S. Y., & Reichl, U.Engineered defective interfering particles of influenza A virus for antiviral treatmentPresented at: 33^rd Annual Meeting of the Society for Virology (GfV)Vienna (Austria), March 25, 2023.

Pelz, L., Rüdiger, D., Hein, M. D., Böhme, J., Bälkner, M., Kershaw, O., Marichal-Gallardo, P., Gruber, A., Genzel, Y., Bruder, D., Kupke, S. Y., & Reichl, U.Genetic engineering of Influenza A virus defective interfering particles towards improved antiviral efficacy and potential use as a live vaccinePresented at: Vaccine Technology IXLos Cabos (Mexico), May 19, 2024.

Rüdiger, D., Opitz, P., Kupke, S. Y., & Reichl, U.A two-dimensional model to predict influenza virus and defective interfering particle coinfection in tissue-like systemsPresented at: 28th ESACT MeetingEdingburgh (Scotland), June 23, 2024.

Rüdiger, D., Opitz, P., Kupke, S. Y., & Reichl, U.Predicting the antiviral efficacy of defective interfering particles against influenza virus infection in tissuesPresented at: KSMB-SMB 2024Seoul (South Korea), June 29, 2024.

Dogra, T., Pelz, L., Boehme, J. D., Baelkner, M., Kershaw, O., Marichal-Gallardo, P., Gruber, A. D., Genzel, Y., Bruder, D., Kupke, S. Y., & Reichl, U.Genetically engineered defective interfering particles of influenza A virus for antiviral treatment and vaccinationPresented at: 17^th Vaccine CongressGlasgow (Scotland), September 24, 2023.

Dogra, T., Pelz, L., Rüdiger, D., Kupke, S. Y., & Reichl, U.Reverse genetics for Influenza a virus to generate genetically engineered defective interfering particles for antiviral treatment and vaccinationPresented at: Vir-AI-DIP Workshop Hamburg (Germany), July 18, 2023.

Küchler, J., Opitz, P., Rüdiger, D., Kupke, S. Y., Genzel, Y., Benndorf, D., & Reichl, U.Absolute quantification of influenza A virus proteins during single-round replication in different host cellsPresented at: 6^th Workshop on Virus DynamicsNagoya (Japan), July 4, 2023.

Kupke, S. Y., Dogra, T., Pelz, L., Hein, M. D., Ndeir, N., Rand, U., Boehme, J., Baelkner, M., Kershaw, O., Winkler, M., Cicin-Sain, L., Bruder, D., Pöhlmann, S., & Reichl, U.Influenza A virus defective interfering particles as antiviral agentsPresented at: 32^nd Annual Meeting of the Society for Virology (GfV)Ulm (Germany), March 28, 2023.

Pelz, L., Dogra, T., Boehme, J. D., Hein, M. D., Marichal-Gallardo, P., Genzel, Y., Bruder, D., Kupke, S. Y., & Reichl, U.Influenza A virus OP7 defective interfering particles: Cell culture-based production and antiviral efficacy in vivoPresented at: Cell Culture Engineering (CCE) XVIII Cancun (Mexico), April 23, 2023.

Pelz, L., Genzel, Y., Kupke, S. Y., & Reichl, U.In-depth characterization and cell culture-based production of influenza A virus defective interfering particlesPresented at: ACTIP fellowship sessionDublin (Ireland), October 11, 2023.

Pelz, L., Rüdiger, D., Dogra, T., Alnaji, F. D., Genzel, Y., Brooke, C. B., Kupke, S. Y., & Reichl, U.Semi-continuous Propagation of Influenza A Virus and Its Defective Interfering Particles: Analyzing the Dynamic Competition To Select Candidates for Antiviral TherapyPresented at: Vir-AI-DIP WorkshopHamburg (Germany), July 18, 2023.

Rüdiger, D., Küchler, J., Piasecka, J., Pontes, C., Kupke, S. Y., & Reichl, U.OP7, a defective interfering particle with mutations: in vitro infection experiments, intracellular model, impact of mutations and mode of antiviral actionPresented at: 6^th Workshop on Virus DynamicsNagoya (japan), July 4, 2023.

Rüdiger, D., Pelz, L., Hein, M. D., Kupke, S. Y., & Reichl, U.Multiscale model of influenza A virus and defective interfering particle co-infection in animal cell culturePresented at: Vir-AI-DIP WorkshopHamburg (Germany), July 18, 2023.

Hein, M., Chawla, A., Arora , P., Cattaneo, M., Winkler, M., Pöhlmann, S., Schughart, K., Genzel, Y., Kupke, S. Y., & Reichl, U.Production of influenza A virus defective interfering particles in a high cell density perfusion cultivation with continuous virus harvestingPresented at: Vaccine Technology VIIISitges (Spain), June 12, 2022.

Hein, M., Dogra, T., Arora , P., Rand , U., Genzel, Y., Cattaneo, M., Winkler, M., Cicin-Sain, L., Bruder, D., Schughart, K., Pöhlmann, S., Kupke, S. Y., & Reichl, U.Influenza A Virus-Derived Defective Interfering Particles for Antiviral TreatmentPresented at: 27th ESACT MeetingLisbon (Portugal), June 26, 2022.

Kupke, S. Y., Hein, M. D., Bdeir, N., Rand, U., Marichal-Gallardo, P., Cicin-Sain, L., Bruder, D., Pöhlmann, S., Schughart, K., & Reichl, U.Influenza A Virus Defective Interfering Particles for Antiviral Treatment of the Influenza Disease and COVID-19Presented at: 31st Annual Meeting of the Society for Virologyonline, March 30, 2022.

Pelz, L., Rüdiger, D., Dogra, T., Alnaji, F. G., Genzel, Y., Brooke, C. B., Kupke, S. Y., & Reichl, U.Long-Term Propagation of Influenza A Virus and Its Defective Interfering Particles: Analyzing Dynamic Competition to Select Antiviral CandidatesPresented at: Vaccine Technology VIIISitges (Spain), June 12, 2022.