Publications of Alexander Rath

Rodrigues Correia Ramos, J., Rath, A., Genzel, Y., Sandig, V., & Reichl, U. (2020)A dynamic model linking cell growth to intracellular metabolism and extracellular by‐product accumulationBiotechnology and Bioengineering, 117 (5), 1533–1553doi: 10.1002/bit.27288.

Cammann, C., Rath, A., Reichl, U., Lingel, H., Brunner-Weintierl, M., Simeoni, L., Schraven, B., & Lindquist, J. A. (2016)Early changes in the metabolic profile of activated CD8+ T cellsBMC Biology, 17 (1), 28doi: 10.1186/s12860-016-0104-x.

Rath, A., Rehberg, M., Janke, R., Genzel, Y., Scholz, S., Noll, T., Rose, T., Sandig, V., & Reichl, U. (2014)The influence of cell growth and enzyme activity changes on intracellular metabolite dynamics in AGE1.HN.AAT cellsJournal of Biotechnology, 178, 43–53doi: 10.1016/j.jbiotec.2014.03.012.

Rehberg, M., Rath, A., Ritter, J., Genzel, Y., & Reichl, U. (2014)Changes in intracellular metabolite pools during growth of adherent MDCK cells in two different mediaApplied Microbiology and Biotechnology, 98 (1), 385–397doi: 10.1007/s00253-013-5329-4.

Borchers, S., Freund, S., Rath, A., Streif, S., Reichl, U., & Findeisen, R. (2013)Identification of Growth Phases and Influencing Factors in Cultivations with AGE1.HN Cells Using Set-Based MethodsPLoS One, 8 (8), e68124doi: 10.1371/journal.pone.0068124.

Freund, S., Rath, A., Barradas, O. P., Skerhutt, S., Scholz, S., Niklas, J., Sandig, V., Rose, T., Heinzle, E., Noll, T., Pörtner, R., Zeng, A. P., & Reichl, U. (2013)Batch-to-batch variability of two human designer cell lines - AGE1.HN and AGE1.HN.AAT - carried out by different laboratories under defined culture conditions using a mathematical modelEngineering in Life Sciences, 13 (6), 580–592doi: 10.1002/elsc.201200111.

Platas Barradas, O., Jandt, U., Da Minh Phan, L., Villanueva, M. E., Schaletzky, M., Rath, A., Freund, S., Reichl, U., Skerhutt, E., Scholz, S., Noll, T., Sandig, V., Pörtner, R., & Zeng, A.-P. (2012)Evaluation of criteria for bioreactor comparison and operation standardization for mammalian cell cultureEngineering in Life Sciences, 12 (5), 518–528doi: 10.1002/elsc.201100163.

Lohr, V., Rath, A., Genzel, Y., Jordan, I., Sandig, V., & Reichl, U. (2009)New avian suspension cell lines provide production of influenza virus and MVA in serum-free media: studies on growth, metabolism and virus propagationVaccine, 27 (36), 4975–4982doi: 10.1016/j.vaccine.2009.05.083.

Lohr, V., Rath, A., Jordan, I., Sandig, V., Genzel, Y., & Reichl, U. (2012)Avian Designer Cells AGE1.CR as Candidates for MVA and Influenza Vaccine ProductionIn: ESACT - Proceedings of the 21st Annual meeting of the European Society for animal cell technology (ESACT), 615–631doi: 10.1007/978-94-007-0884-6_102.

Barradas, O. P., Jandt, U., Phan, L. D., Villanueva, M., Rath, A., Reichl, U., Schräder, E., Scholz, S., Noll, T., Sandig, V., Pörtner, R., & Zeng, A. P. (2011)Criteria for bioreactor comparison and operation standardisation during process development for mammalian cell cultureIn: BMC Proceedings, P47doi: 10.1186/1753-6561-5-S8-P47.

Scholz, S., Luebbecke, M., Rath, A., Schraeder, E., Rose, T., Büntemeyer, H., Scheper, T., Reichl, U., & Noll, T. (2011)Characterization of the human AGE1.HN cell line: a systems biology approachIn: BMC Proceedings, P78doi: 10.1186/1753-6561-5-S8-P78.

Schräder, E., Scholz, S., Niklas, J., Rath, A., Barradas, O. P., Jandt, U., Sandig, V., Rose, T., Pörtner, R., Reichl, U., Zeng, A. P., Heinzle, E., & Noll, T. (2011)Characterisation of cultivation of the human cell line AGE1.HN.AATIn: BMC Proceedings, P87doi: 10.1186/1753-6561-5-S8-P87.

Rath, A., Scholz, S., Noll, T., Janke, R., Genzel, Y., Rose, T., Sandig, V., & Reichl, U.Insights into mammalian energy metabolism: connecting intracellular metabolites and maximum enzyme activitiesPresented at: GVC/DECHEMA Vortrags- und Diskussionstagung - Biopharmazeutische ProduktionFreiburg, May 14, 2012.

Lohr, V., Rath, A., Jordan, I., Sandig, V., Genzel, Y., & Reichl, U.Avian designer cells AGE1.CR: possible candidates for MVA and influenza vaccine production?Presented at: 21st ESACT MeetingDublin, Ireland, June 7, 2009.

Rath, A., Lohr, V., Genzel, Y., Schwarzer, J., Rapp, E., Sandig, V., Jordan, I., & Reichl, U.Influenza and modified vaccinia Ankara (MVA) production in avian designer cellsPresented at: BioperspectivesHannover, Germany, October 9, 2008.

Rodrigues Correia Ramos, J., Rath, A., Genzel, Y., Rose, T., Sandig, V., & Reichl, U.A Dynamic Model of Growth and Metabolism of AGE1.HN Suspension CellsPresented at: 6th IFAC Conference on Foundations of Systems Biology in Engineering (FOSBE)Magdeburg, Germany, October 9, 2016.

Blechert, A.-K., Rath, A., Sann, H., Spaner, D., Coroadinha, A. S., Genzel, Y., & Reichl, U.Towards an analytical platform for metabolic studies in adherent and suspension cells: intracellular metabolite concentrations and maximum enzyme activitiesPresented at: 23rd ESACT MeetingLille, France, June 23, 2013.

Freund, S., Rath, A., Rose, T., Sandig, V., & Reichl, U.Metabolic Flux Analysis of AAT Production in AGE1.HN.AAT Cells under Different Cultivation ConditionsPresented at: ESBES - 9 th European Symposium on Biochemical Engineering ScienceIstanbul, September 24, 2012.

Freund, S., Rath, A., Sandig, V., Rose, T., & Reichl, U.Comparison of the productivity of a new human cell line in different steady states of continuous cultivations using MFAPresented at: Metabolic Engineering IXBiarritz, France, June 3, 2012.

Freund, S., Rath, A., Sandig, V., Rose, T., & Reichl, U.AGE1.HN.AAT - growth of a human cell line in glucose excess and limitation: comparison of different metabolic states via stationary metabolic flux analysisPresented at: 22nd ESACT MeetingVienna, Austria, May 15, 2011.