Publications of Yvonne Genzel
All genres
Journal Article (107)
2019
Journal Article
Tapia, F., Wohlfahrt, D., , , Genzel, Y., & Reichl, U. (2019)Continuous influenza virus production in a tubular bioreactor system provides stable titers and avoids the “von Magnus effect”PLoS One, 14 (11), e0224317doi: 10.1371/journal.pone.0224317.
Journal Article
Vazquez-Ramirez, D., , , Genzel, Y., & Reichl, U. (2019)High titer MVA and influenza A virus production using a hybrid fed-batch/perfusion strategy with an ATF systemApplied Microbiology and Biotechnology, 103 (7), 3025–3035doi: 10.1007/s00253-019-09694-2.
2018
Journal Article
Nikolay, A., , Reichl, U., & Genzel, Y. (2018)Propagation of Brazilian Zika virus strains in static and suspension cultures using Vero and BHK cellsVaccine, 36 (22), 3140–3145doi: 10.1016/j.vaccine.2017.03.018.
Journal Article
Nikolay, A., , , Genzel, Y., & Reichl, U. (2018)Process intensification of EB66 ® cell cultivations leads to high-yield yellow fever and Zika virus productionApplied Microbiology and Biotechnology, 102 (20), 8725–8737doi: 10.1007/s00253-018-9275-z.
Journal Article
, Tapia, F., , , , , , Genzel, Y., & (2018)Assessing the Importance of Domestic Vaccine Manufacturing Centers: An Overview of Immunization Programs, Vaccine Manufacture, and DistributionFrontiers in Immunology, 9, 26doi: 10.3389/fimmu.2018.00026.
Journal Article
Vazquez-Ramirez, D., Genzel, Y., , , & Reichl, U. (2018)High-cell-density cultivations to increase MVA virus productionVaccine, 36 (22), 3124–3133doi: 10.1016/j.vaccine.2017.10.112.
Journal Article
Wasik, M., Eichwald, L., Genzel, Y., & Reichl, U. (2018)Cell culture-based production of defective interfering particles for influenza antiviral therapyApplied Microbiology and Biotechnology, 102 (3), 1167–1177doi: 10.1007/s00253-017-8660-3.
2017
Journal Article
Tapia, F., , Genzel, Y., & Reichl, U. (2017)Efficient and stable production of Modified Vaccinia Ankara virus in two-stage semi-continuous and in continuous stirred tank cultivation systemsPLoS One, 12 (8), e0182553doi: 10.1371/journal.pone.0182553.
2016
Journal Article
Kluge, S., Genzel, Y., Laus, K., Serve, A., Pflugmacher, A., Peschel, B., Rapp, E., & Reichl, U. (2016)Ezrin and HNRNP expression correlate with increased virus release rate and early onset of virus-induced apoptosis of MDCK suspension cellsBiotechnology Journal, 11 (10), 1332–1342doi: 10.1002/biot.201600384.
Journal Article
, , , , Blechert, A.-K., Genzel, Y., , , & (2016)Increased titer and reduced lactate accumulation in recombinant retrovirus production through the down-regulation of HIF1 and PDKBiotechnology and Bioengineering, 113 (1), 150–162doi: 10.1002/bit.25691.
Journal Article
Tapia, F., Vázquez-Ramirez, D., Genzel, Y., & Reichl, U. (2016)Bioreactors for high cell density and continuous multi-stage cultivations: options for process intensification in cell culture-based viral vaccine productionApplied Microbiology and Biotechnology, 100 (5), 2121–2132doi: 10.1007/s00253-015-7267-9.
2015
Journal Article
, , Laske, T., , Genzel, Y., , , & (2015)Production of canine adenovirus type 2 in serum-free suspension cultures of MDCK cellsApplied Microbiology and Biotechnology, 99 (17), 7059–7068doi: 10.1007/s00253-015-6636-8.
Journal Article
Gallo Ramirez, L. E., Nikolay, A., Genzel, Y., & Reichl, U. (2015)Bioreactor concepts for cell culture-based viral vaccine productionExpert Review of Vaccines, 14 (9), 1181–1191doi: 10.1586/14760584.2015.1067144.
Journal Article
Genzel, Y. (2015)Designing cell lines for viral vaccine production: Where do we stand?Biotechnology Journal, 10 (5), 728–740doi: 10.1002/biot.201400388.
Journal Article
Kluge, S., Benndorf, D., Genzel, Y., , Rapp, E., & Reichl, U. (2015)Monitoring changes in proteome during stepwise adaptation of a MDCK cell line from adherence to growth in suspensionVaccine, 33 (35), 4269–4280doi: 10.1016/j.vaccine.2015.02.077.
2014
Journal Article
Genzel, Y., Vogel, T., Buck, J., Behrendt, I., Vazquez-Ramirez, D., , , & Reichl, U. (2014)High cell density cultivations by alternating tangential flow (ATF) perfusion for influenza A virus production using suspension cellsVaccine, 32 (24), 2770–2781doi: 10.1016/j.vaccine.2014.02.016.
Journal Article
Lohr, V., Hädicke, O., Genzel, Y., , , Klamt, S., & Reichl, U. (2014)The avian cell line AGE1.CR.pIX characterized by metabolic flux analysisBMC Biotechnology, 14, 72doi: 10.1186/1472-6750-14-72.
Journal Article
Rath, A., Rehberg, M., Janke, R., Genzel, Y., , , , , & Reichl, U. (2014)The influence of cell growth and enzyme activity changes on intracellular metabolite dynamics in AGE1.HN.AAT cellsJournal of Biotechnology, 178, 43–53doi: 10.1016/j.jbiotec.2014.03.012.
Journal Article
Rehberg, M., Rath, A., Ritter, J., Genzel, Y., & Reichl, U. (2014)Changes in intracellular metabolite pools during growth of adherent MDCK cells in two different mediaApplied Microbiology and Biotechnology, 98 (1), 385–397doi: 10.1007/s00253-013-5329-4.
Journal Article
Tapia, F., Vogel, T., Genzel, Y., Behrendt, I., , , & Reichl, U. (2014)Production of high-titer human influenza A virus with adherent and suspension MDCK cells cultured in a single-use hollow fiber bioreactorVaccine, 32 (8), 1003–1011doi: 10.1016/j.vaccine.2013.11.044.