Publications of Felipe Tapia

Journal Article (8)

2021
Journal Article
Gränicher, G., Tapia, F., Behrendt, I., Jordan, I., Genzel, Y., & Reichl, U. (2021)Production of Modified Vaccinia Ankara Virus by Intensified Cell Cultures: A Comparison of Platform Technologies for Viral Vector ProductionBiotechnology Journal, 16 (1), e2000024doi: 10.1002/biot.202000024.
2019
Journal Article
Tapia, F., Laske, T., Wasik, M., Rammhold, M., Genzel, Y., & Reichl, U. (2019)Production of Defective Interfering Particles of Influenza A Virus in Parallel Continuous Cultures at Two Residence Times—Insights From qPCR Measurements and Viral Dynamics ModelingFrontiers in Bioengineering and Biotechnology, 7, 275doi: 10.3389/fbioe.2019.00275.
Journal Article
Tapia, F., Wohlfahrt, D., Sandig, V., Jordan, I., Genzel, Y., & Reichl, U. (2019)Continuous influenza virus production in a tubular bioreactor system provides stable titers and avoids the “von Magnus effect”PLoS One, 14 (11), e0224317doi: 10.1371/journal.pone.0224317.
2018
Journal Article
Rey-Jurado, E., Tapia, F., Muñoz-Durango, N., Lay, M. K., Carreño, L. J., Riedel, C. A., Bueno, S. M., Genzel, Y., & Kalergis, A. M. (2018)Assessing the Importance of Domestic Vaccine Manufacturing Centers: An Overview of Immunization Programs, Vaccine Manufacture, and DistributionFrontiers in immunology, 9, 26doi: 10.3389/fimmu.2018.00026.
2017
Journal Article
Tapia, F., Jordan, I., Genzel, Y., & Reichl, U. (2017)Efficient and stable production of Modified Vaccinia Ankara virus in two-stage semi-continuous and in continuous stirred tank cultivation systemsPLoS One, 12 (8), e0182553doi: 10.1371/journal.pone.0182553.
2016
Journal Article
Tapia, F., Vázquez-Ramirez, D., Genzel, Y., & Reichl, U. (2016)Bioreactors for high cell density and continuous multi-stage cultivations: options for process intensification in cell culture-based viral vaccine productionApplied Microbiology and Biotechnology, 100 (5), 2121–2132doi: 10.1007/s00253-015-7267-9.
2014
Journal Article
Diba, M., Goudouri, O.-M., Tapia, F., & Boccaccini, A. R. (2014)Magnesium-containing bioactive polycrystalline silicate-based ceramics and glass-ceramics for biomedical applicationsCurrent Opinion in solid state & materials science, 18 (3), 147–167doi: 10.1016/j.cossms.2014.02.004 .
Journal Article
Tapia, F., Vogel, T., Genzel, Y., Behrendt, I., Hirschel, M., Gangemi, J. D., & Reichl, U. (2014)Production of high-titer human influenza A virus with adherent and suspension MDCK cells cultured in a single-use hollow fiber bioreactorVaccine, 32 (8), 1003–1011doi: 10.1016/j.vaccine.2013.11.044.

Meeting Abstract (2)

2019
Meeting Abstract
Hein, M., Tapia, F., Genzel, Y., Kupke, S. Y., & Reichl, U. (2019)Continuous mode of production for two classes of defective interfering influenza A virus particles as antiviral candidatesIn: Integrated Continuous Biomanufacturing IV, 76.
2017
Meeting Abstract
Tapia, F., Genzel, Y., Reichl, U., & Sandig, V. (2017)Stirred tanks in cascades and plug-flow tubular bioreactors for continuous production of viral vaccinesIn: ECI Symposium Series.

Talk (14)

2020
Talk
Reichl, U., Vazquez-Ramirez, D., Tapia, F., Nikolay, A., & Genzel, Y.Cell Culture-based Viral Vaccines: Process Intensification and MonitoringPresented at: Plenarsitzung der Sächischen Akademie der Wissenschaften zu LeipzigLeipzig, Germany, November 13, 2020.
2019
Talk
Laske, T., Tapia, F., Wasik, M., Rammhold, M., Genzel, Y., & Reichl, U.Production of defective interfering particles of influenza A virus in continuously cultured bioreactors at two residence times - insights from within-host virus dynamicsPresented at: 4th Workshop on Viral DynamicsParis, France, October 21, 2019.
Talk
Nikolay, A., Tapia, F., Marichal-Gallardo, P., Pralow, A., Hoffmann, M., Rapp, E., Genzel, Y., & Reichl, U.Moderne Methoden der ImpfstoffherstellungPresented at: Wissenschaft im RathausMagdeburg, Germany, September 30, 2019.
Talk
Nikolay, A., Tapia, F., Marichal-Gallardo, P., Pralow, A., Hoffmann, M., Rapp, E., Genzel, Y., & Reichl, U.Cell Culture-based Viral Vaccines: Process Intensification and MonitoringPresented at: Cuba Symposium “Frontiers of Science”Havanna, Cuba, March 5, 2019.
Talk
Reichl, U., Vazquez-Ramirez, D., Tapia, F., Nikolay, A., Genzel, Y., & Rapp, E.Process Intensification in Viral Vaccine ManufacturingPresented at: International Symposium on Pharmaceutical Engineering Research – SPhEReBraunschweig, Germany, September 25, 2019.
Talk
Tapia, F.A universal platform for continuous manufacturing of viral vaccines and gene therapy vectorsPresented at: 5. Workshop Bio-VerfahrenstechnikFraunhofer CBP Leuna, Germany, September 19, 2019.
Talk
Tapia, F., Marichal-Gallardo, P., & Reichl, U.A universal platform for continuous manufacturing of viral vaccines & gene therapy vectorsPresented at: Workshop BioverfahrenstechnikLeuna, Germany, September 19, 2019.
2017
Talk
Tapia, F.A continuous tubular bioreactor for stable production of influenza virus vaccinesPresented at: 25th ESACT MeetingLausanne, Switzerland, May 14, 2017.
Talk
Tapia, F.A continuous tubular bioreactor for stable production of influenza virus vaccinesPresented at: CChIQ2017: National Conference of Chemical EngineeringSantiago, Chile, May 14, 2017.
Talk
Tapia, F.A continuous tubular bioreactor for stable production of influenza virus vaccinesPresented at: SOMICH Coloquios de MicrobiologiaSantiago, Chile, May 15, 2017.
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