Publications of Thomas Bissinger

Journal Article (6)

2022
Journal Article
Rodrigues Correia Ramos, J., Bissinger, T., Genzel, Y., & Reichl, U. (2022)Impact of Influenza A Virus Infection on Growth and Metabolism of Suspension MDCK Cells Using a Dynamic ModelMetabolites, 12 (3), 239doi: 10.3390/metabo12030239.
2021
Journal Article
Bissinger, T., Wu, Y., Marichal-Gallardo, P., Riedel, D., Liu, X., Genzel, Y., Tan, W. S., & Reichl, U. (2021)Towards integrated production of an influenza A vaccine candidate with MDCK suspension cellsBiotechnology and Bioengineering, 118 (10), 3996–4013doi: 10.1002/bit.27876.
Journal Article
Wu, Y., Bissinger, T., Genzel, Y., Liu, X., Reichl, U., & Tan, W.-S. (2021)High cell density perfusion process for high yield of influenza A virus production using MDCK suspension cellsApplied Microbiology and Biotechnology, 105 (4), 1421–1434doi: 10.1007/s00253-020-11050-8.
2019
Journal Article
Bissinger, T., Fritsch, J., Mihut, A. N., Wu, Y., Liu, X., Genzel, Y., Tan, W.-S., & Reichl, U. (2019)Semi-perfusion cultures of suspension MDCK cells enable high cell concentrations and efficient influenza A virus productionVaccine, 37 (47), 7003–7010doi: 10.1016/j.vaccine.2019.04.054.
Journal Article
Koch, S., Kohrs, F., Lahmann, P., Bissinger, T., Wendschuh, S., Benndorf, D., Reichl, U., & Klamt, S. (2019)RedCom: A strategy for reduced metabolic modeling of complex microbial communities and its application for analyzing experimental datasets from anaerobic digestionPLoS Computational Biology, 15 (2), e1006759doi: 10.1371/journal.pcbi.1006759.
2017
Journal Article
Kohrs, F., Heyer, R., Bissinger, T., Kottler, R., Schallert, K., Püttker, S., Behne, A., Rapp, E., Benndorf, D., & Reichl, U. (2017)Proteotyping of laboratory-scale biogas plants reveals multiple steady-states in community compositionAnaerobe, 46, 56–68doi: 10.1016/j.anaerobe.2017.02.005.

Book Chapter (1)

2020
Book Chapter
Nikolay, A., Bissinger, T., Gränicher, G., Wu, Y., Genzel, Y., & Reichl, U. (2020)Perfusion Control for High Cell Density Cultivation and Viral Vaccine ProductionAnimal Cell Biotechnology141–168New York: Humanadoi: 10.1007/978-1-0716-0191-4_9.

Meeting Abstract (2)

2018
Meeting Abstract
Bissinger, T., Reichl, U., Genzel, Y., Wu, Y., Liu, X., & Tan, W.-S. (2018)Highly efficient influenza virus production: A MDCK-based high-cell-density processIn: Vaccine Technology VII, 13.
Meeting Abstract
Wu, Y., Liu, X., Tan, W.-S., Bissinger, T., Genzel, Y., & Reichl, U. (2018)Efficient influenza vaccine manufacturing: Single MDCK suspension cells in chemically defined mediumIn: Vaccine Technology VII, 5.

Talk (1)

2016
Talk
Kohrs, F., Heyer, R., Benndorf, D., Bissinger, T., Kottler, R., Fronk, K., Rapp, E., & Reichl, U.Kultivierung und Metaproteomanalyse anaerober mikrobieller GemeinschaftenPresented at: 23. SIMBA-TreffenHavelberg, Germany, April 27, 2016.

Poster (7)

2019
Poster
Rodrigues Correia Ramos, J., Bissinger, T., Genzel, Y., & Reichl, U.A Dynamic Model for Cell Growth, Metabolism & Virus Production of MDCK Suspension CellsPresented at: YCOPE 2019Magdeburg, Germany, March 18, 2019.
2018
Poster
Bissinger, T., Rodrigues Correia Ramos, J., Ringeisen, J., Genzel, Y., & Reichl, U.Dynamics of intracellular metabolite pools in MDCK suspension cells during cell growth and influenza virus infectionPresented at: Cell Culture Engineering XVITampa, Florida, USA, May 6, 2018.
Poster
Bissinger, T., Wu, Y., Genzel, Y., Liu, X., Wen-Song, T., & Reichl, U.Efficient influenza virus production: a MDCK-based high-cell-density processPresented at: Vaccine Technology VIIMont Tremblant, Canada, June 17, 2018.
2017
Poster
Bissinger, T., Rodrigues Correia Ramos, J., Ringeisen, J., Genzel, Y., & Reichl, U.Intracellular Metabolic Pool Dynamics in MDCK Suspension Cells during Growth and Influenza Virus InfectionPresented at: 25th ESACT MeetingLausanne, Switzerland, May 14, 2017.
Poster
Kohrs, F., Heyer, R., Bissinger, T., Kottler, R., Schallert, K., Püttker, S., Behne, A., Rapp, E., Benndorf, D., & Reichl, U.Proteotyping of microbial communities from laboratory-scale biogas plants reveals multiple steady-statesPresented at: 14th Symposium on Bacterial Genetics and Ecology (BAGECO 14)Aberdeen, Scotland, June 4, 2017.
2015
Poster
Bissinger, T., Schleuß, T., Thom, V., Wolff, M., & Reichl, U.Separation of Enterovirus 71 Virus Like Particles from Baculovirus by Crossflow FiltrationPresented at: ESACT 2015Barcelona, Spain, May 31, 2015.
2014
Poster
Wolff, M. W., Meininger, M., Bissinger, T., Djurup, R., Villain, L., Schleuß, T., Thom, V., Cardosa, J., & Reichl, U.Development of a Purification Strategy for Enterovirus 71 Like Particles for Vaccine ProductionPresented at: The Recovery of Biological Products XVI ConferenceRostock, Germany, July 27, 2014.

Thesis - PhD (1)

2020
Thesis - PhD
Bissinger, T. (2020)Evaluation of MDCK suspension cell lines for influenza A virus production: media, metabolism, and process conditionsPhD Thesis, Otto-von-Guericke-Universität, Magdeburgdoi: 10.25673/35498.

Thesis - Diploma (1)

2013
Thesis - Diploma
Bissinger, T. (2013)Separation of Enterovirus 71 Virus Like Particles from Baculovirus by Cross Flow FiltrationDiploma Thesis, Universität Stuttgart, Stuttgart.
Go to Editor View