Head of the Group

Prof. Dr.-Ing. Udo Reichl
Prof. Dr.-Ing. Udo Reichl
Phone: +49 391 6110 201
Fax: +49 391 6110 203
Room: N0.19

Contact Person

Annegret Frauendienst
Phone:+49 391 6110-200Fax:+49 391 6110-203

Group Page

Publications

Publications BPE group

Journal Article (20)

  1. 1.
    Journal Article
    Carvalho, S. B.; Fortuna, A. R.; Wolff, M. W.; Peixoto, C.; Alves, P. M.; Reichl, U.; Carrondo, M. J. T.: Purification of influenza virus-like particles using sulfated cellulose membrane adsorbers. Journal of Chemical Technology and Biotechnology 93 (7), pp. 1988 - 1996 (2018)
  2. 2.
    Journal Article
    Chuzel, L.; Ganatra, M. B.; Rapp, E.; Henrissat, B.; Taron, C. H.: Functional metagenomics identifies an exosialidase with an inverting catalytic mechanism that defines a new glycoside hydrolase family (GH156). The Journal of Biological Chemistry 293, pp. 18138 - 18150 (2018)
  3. 3.
    Journal Article
    Clerc, F.; Novokmet, M.; Dotz, V.; Reiding, K. R.; de Haan , N.; Kammeijer, G. S.M.; Dalebout, H.; Bladergroen, M. R.; Vukovic, F.; Rapp, E. et al.; Targan, S. R.; Barron, G.; Manetti , N.; Latiano, A.; McGovern, D. P.B.; Annese, V.; Lauc, G.; Wuhrer, M.: Plasma N-Glycan Signatures Are Associated With Features of Inflammatory Bowel Diseases. Gastroenterology 155 (3), pp. 829 - 843 (2018)
  4. 4.
    Journal Article
    Fischer, L. M.; Wolff, M. W.; Reichl, U.: Purification of cell culture-derived influenza A virus via continuous anion exchange chromatography on monoliths. Vaccine 36 (22), pp. 3153 - 3160 (2018)
  5. 5.
    Journal Article
    Fischöder, T.; Cajic, S.; Reichl, U.; Rapp, E.; Elling , L.: Enzymatic cascade synthesis provides novel linear human milk oligosaccharides as reference standards for xCGE-LIF based high-throughput analysis. Biotechnology Journal, e1800305 (2018)
  6. 6.
    Journal Article
    Fortuna, A. R.; Taft, F.; Villain, L.; Wolff, M. W.; Reichl, U.: Optimization of cell culture-derived influenza A virus particles purification using sulfated cellulose membrane adsorbers. Engineering in Life Sciences 18 (1), pp. 29 - 39 (2018)
  7. 7.
    Journal Article
    Hoffmann, M.; Pioch, M.; Pralow, A.; Hennig, R.; Kottler, R.; Reichl, U.; Rapp, E.: The Fine Art of Destruction: A Guide to In-Depth Glycoproteomic Analyses – Exploiting the Diagnostic Potential of Fragment Ions. Proteomics 18 (24), e1800282 (2018)
  8. 8.
    Journal Article
    Mahour, R.; Klapproth, J.; Rexer, T.; Schildbach, A.; Klamt, S.; Pietzsch, M.; Rapp, E.; Reichl, U.: Establishment of a five-enzyme cell-free cascade for the synthesis of uridine diphosphate N-acetylglucosamine. Journal of Biotechnology 283, pp. 120 - 129 (2018)
  9. 9.
    Journal Article
    Möginger, U.; Grunewald, S.; Hennig, R.; Kuo, C.-W.; Schirmeister, F.; Voth, H.; Rapp, E.; Khoo, K.-H.; Seeberger, P. H.; Simon, J. C. et al.; Kolarich, D.: Alterations of the Human Skin N- and O-Glycome in Basal Cell Carcinoma and Squamous Cell Carcinoma. Frontiers in Oncology 8 (70) (2018)
  10. 10.
    Journal Article
    Muth, T.; Kohrs, F.; Heyer, R.; Benndorf, D.; Rapp, E.; Reichl, U.; Martens, L.; Renard, B. Y.: MPA Portable: A Stand-Alone Software Package for Analyzing Metaproteome Samples on the Go. Analytical Chemistry 90, pp. 685 - 689 (2018)
  11. 11.
    Journal Article
    Nguyen-Khuong, T.; Pralow, A.; Reichl, U.; Rapp, E.: Improvement of electrospray stability in negative ion mode for nano-PGC-LC-MS glycoanalysis via post-column make-up flow. Glycoconjugate Journal 35 (6), pp. 499 - 509 (2018)
  12. 12.
    Journal Article
    Nikolay, A.; Léon, A.; Schwamborn, K.; Genzel, Y.; Reichl, U.: Process intensification of EB66 ® cell cultivations leads to high-yield yellow fever and Zika virus production. Applied Microbiology and Biotechnology 102 (20), pp. 8725 - 8737 (2018)
  13. 13.
    Journal Article
    Nikolay, A.; Casthilho, L. R.; Reichl, U.; Genzel, Y.: Propagation of Brazilian Zika virus strains in static and suspension cultures using Vero and BHK cells. Vaccine 36 (28), pp. 3140 - 3145 (2018)
  14. 14.
    Journal Article
    Pioch, M.; Hoffmann, M.; Pralow, A.; Reichl, U.; Rapp, E.: GlyXtoolMS: An Open-Source Pipeline for Semiautomated Analysis of Glycopeptide Mass Spectrometry Data. Analytical Chemistry 90 (20), pp. 11908 - 11916 (2018)
  15. 15.
    Journal Article
    Rexer, T.; Schildbach, A.; Klapproth, J.; Schierhorn, A.; Mahour, R.; Pietzsch, M.; Rapp, E.; Reichl, U.: One pot synthesis of GDP-mannose by a multi-enzyme cascade for enzymatic assembly of lipid-linked oligosaccharides. Biotechnology and Bioengineering 115 (1), pp. 192 - 205 (2018)
  16. 16.
    Journal Article
    Rey-Jurado, E.; Tapia, F.; Muñoz-Durango, N.; Lay, M.K.; Carreño, L. J.; Riedel, C. A.; Bueno, S. M.; Genzel, Y.; Kalergis, A. M.: Assessing the Importance of Domestic Vaccine Manufacturing Centers: An Overview of Immunization Programs, Vaccine Manufacture, and Distribution. Frontiers in immunology 9, 26 (2018)
  17. 17.
    Journal Article
    Vazquez-Ramirez, D.; Genzel, Y.; Jordan, I.; Sandig, V.; Reichl, U.: High-cell-density cultivations to increase MVA virus production. Vaccine 36 (22), pp. 3124 - 3133 (2018)
  18. 18.
    Journal Article
    Vodovnik, M.; Vrabec, K.; Hellwig, P.; Benndorf, D.; Sezun, M.; Gregori, A.; Gottumukkala, L. D.; Anderson, R. C.; Reichl, U.: Valorisation of deinking sludge as a substrate for lignocellulolytic enzymes production by Pleurotus ostreatus. Journal of Cleaner Production 197 (Part 1), pp. 253 - 263 (2018)
  19. 19.
    Journal Article
    Wasik, M.; Eichwald, L.; Genzel, Y.; Reichl, U.: Cell culture-based production of defective interfering particles for influenza antiviral therapy. Applied Microbiology and Biotechnology 102 (3), pp. 1167 - 1177 (2018)
  20. 20.
    Journal Article
    Wenzel, L.; Heyer, R.; Schallert, K.; Löser, L.; Wünschiers, R.; Reichl, U.; Benndorf, D.: SDS-PAGE fractionation to increase metaproteomic insight into the taxonomic and functional composition of microbial communities for biogas plant samples. Engineering in Life Sciences 18 (7), pp. 498 - 509 (2018)

Conference Paper (2)

  1. 21.
    Conference Paper
    Duvigneau, S.; Dürr, R.; Laske, T.; Bachmann, M.; Dostert, M.; Reichl, U.; Kienle, A.: Mathematical modeling as a tool to improve influenza vaccine production processes. FOSBE 2018, Chicago, Illinois, USA, August 05, 2018 - August 08, 2018. IFAC-PapersOnLine 51 (19), pp. 1 - 4 (2018)
  2. 22.
    Conference Paper
    Rüdiger, D.; Kupke, S. Y.; Reichl, U.: A multiscale model of influenza A virus replication covering highly different infection conditions in cell cultures. IFAC-PapersOnLine 51 (19), pp. 32 - 33 (2018)

Meeting Abstract (11)

  1. 23.
    Meeting Abstract
    Bissinger, T.; Reichl, U.; Genzel, Y.; Wu, Y.; Liu, X.; Tan, W.-S.: Highly efficient influenza virus production: A MDCK-based high-cell-density process. In: Vaccine Technology VII. Vaccine Technology VII, Mont Tremblant, Canada, June 17, 2018 - June 22, 2018. (2018)
  2. 24.
    Meeting Abstract
    Coronel, J.; Genzel, Y.; Reichl, U.; Behrendt, I.; Buergin, T.; Andereli, T.; Sandig, V.: Orbital shaken bioreactor for influenza A virus production in high cell density cultivations. In: Vaccine Technology VII. Vaccine Technology VII, Mont Tremblant, Canada, June 17, 2018 - June 22, 2018. (2018)
  3. 25.
    Meeting Abstract
    Fortuna, A. R.; Taft, F.; Villain, L.; Wolff, M. W.; Reichl, U.: Continuous purification of cell culture-derived influenza A virus particles through pseudo- affinity membrane chromatography. In: Vaccine Technology VII. Vaccine Technology VII, Mont Tremblant, Canada, June 17, 2018 - June 22, 2018. (2018)
  4. 26.
    Meeting Abstract
    Gränicher, G.; Genzel, Y.; Reichl, U.; John, K.; Sandig, V.; Karlas, A.: A new porcine suspension cell line (PBG.PK-21) provides efficient production for influenza and yellow fever vaccine viruses. In: Vaccine Technology VII. Vaccine Technology VII, Mont Tremblant, Canada, June 17, 2018 - June 22, 2018. (2018)
  5. 27.
    Meeting Abstract
    Kupke, S. Y.; Riedel, D.; Frensing, T.; Zmora, P.; Reichl, U.: Single-cell analysis uncovers a novel influenza A virus-derived defective interfering particle for antiviral therapy. In: Vaccine Technology VII. Vaccine Technology VII, Mont Tremblant, Canada, June 17, 2018 - June 22, 2018. (2018)
  6. 28.
    Meeting Abstract
    Marichal-Gallardo, P.; Fortuna, A. R.; Genzel, Y.; Wolff, M. W.; Reichl, U.: Purifying viruses with a sheet of paper: Single-use steric exclusion chromatography as a capture platform for vaccine candidates. In: Vaccine Technology VII. Vaccine Technology VII, Mont Tremblant, Canada, June 17, 2018 - June 22, 2018. (2018)
  7. 29.
    Meeting Abstract
    Nikolay, A.; Genzel, Y.; Schwamborn, K.; Leon, A.; Reichl, U.: Flavivirus production in perfusion processes using the EB66® cell line. In: Vaccine Technology VII. Vaccine Technology VII, Mont Tremblant, Canada, June 17, 2018 - June 22, 2018. (2018)
  8. 30.
    Meeting Abstract
    Peixoto, C.; Carvalho, S. B.; Carrondo, M. J.T.; Alves , P. M.; Fortuna, A. R.; Reichl, U.; Wolff, M. W.: Addressing the challenges of influenza virus-like particles purification. In: Vaccine Technology VII. Vaccine Technology VII, Mont Tremblant, Canada, June 17, 2018 - June 22, 2018. (2018)
  9. 31.
    Meeting Abstract
    Rossdamm, C.; Konze, S. A.; Oberbeck, A.; Rapp, E.; Gerardy-Schahn, R.; von Itzstein, M.; Buettner, F. F. R.: CGE-LIF as a novel approach for the analysis of glycosphingolipid-derived glycans. In: GLYCOBIOLOGY, Vol. 28, pp. 1057 - 1058. Annual Meeting of the Society-for-Glycobiology (SFG), New Orleans, LA (USA), November 05, 2018 - November 08, 2018. (2018)
  10. 32.
    Meeting Abstract
    Taft, F.; Köhler, R.; Van Teeffelen, S.; Fortuna, A. R.; Wolff, M. W.; Reichl, U.; Villain, L.; Boulais, A.: Influenza virus capture using membrane chromatography: Improving selectivity by matrix design and pseudo-affinity ligand interactions. In: Vaccine Technology VII. Vaccine Technology VII, Mont Tremblant, Canada, June 17, 2018 - June 22, 2018. (2018)
  11. 33.
    Meeting Abstract
    Wu, Y.; Liu, X.; Tan, W.-S.; Bissinger, T.; Genzel, Y.; Reichl, U.: Efficient influenza vaccine manufacturing: Single MDCK suspension cells in chemically defined medium. In: Vaccine Technology VII. Vaccine Technology VII, Mont Tremblant, Canada, June 17, 2018 - June 22, 2018. (2018)

Talk (10)

  1. 34.
    Talk
    Benndorf, D.: Speedup of metaproteomics pipelines - from samples to microbial community data in less than 24 hours. 3rd International Metaproteome Symposium, Leipzig, Germany (2018)
  2. 35.
    Talk
    Genzel, Y.: Perfusion with shaken bioreactors. Meeting on orbital shaken bioreactors (from µL up to 2500 L), Mas Boada, Spain (2018)
  3. 36.
    Talk
    Genzel, Y.: Intensified cell-based viral vaccine processes: from continuous to perfusion to hybrid systems. BioProNet Meeting, London, UK (2018)
  4. 37.
    Talk
    Genzel, Y.: ESACT Vaccine Course: Upstream Process Development: From Master Seed to Production. ESACT Vaccine Course: Upstream Process Development - From Master Seed to Production 2018, Llafranc, Spain (2018)
  5. 38.
    Talk
    Genzel, Y.: ESACT Vaccine Course: Upstream Process Intensification. ESACT Course 2018, Llafranc, Spain (2018)
  6. 39.
    Talk
    Genzel, Y.: ESACT Vaccine Course: Introduction to Cell Culture-produced Viral Vaccines. ESACT Course 2018, Llafranc, Spain (2018)
  7. 40.
    Talk
    Hoffmann, M.: Towards Understanding of Congenital Disorders of Glycosylation: A Glyco(proteo)mic Approach to Unravel the Interplay between Different Types of Glycosylation. DFG FOR 2509 Meeting , Höchst (Odenwald), Germany (2018)
  8. 41.
    Talk
    Kupke, S. Y.: Single-Cell analysis uncover a novel influenza A virus-derived defective interfering particle for antiviral therapy. Vaccine Technology VII, Mont Tremblant, Canada (2018)
  9. 42.
    Talk
    Nikolay, A.: Stable animal cell growth in perfusion processes: Using on-line permittivity sensors to control cell-specific perfusion rates. 5th BioProScale Symposium, Berlin, Germany (2018)
  10. 43.
    Talk
    Nikolay, A.: Cell-culture-based perfusion processes for Flavivirus production. 5th Laupheim Biotech Days, Laupheim, Germany (2018)

Poster (9)

  1. 44.
    Poster
    Benndorf, D.; Heyer, R.; Schallert, K.; Püttker, S.; Kohrs, F.; Theuerl, S.; Schlüter, A.; Reichl, U.: Metaproteomics of biogas plants reveals that biogas producing microbial communities are shaped by syntrophy, competition and phage-host interactions. International Society for Microbial Ecology Conference (ISME), Leipzig Germany (2018)
  2. 45.
    Poster
    Bissinger, T.; Rodrigues Correia Ramos, J.; Ringeisen, J.; Genzel, Y.; Reichl, U.: Dynamics of intracellular metabolite pools in MDCK suspension cells during cell growth and influenza virus infection. Cell Culture Engineering XVI, Tampa, Florida, USA (2018)
  3. 46.
    Poster
    Bissinger, T.; Wu, Y.; Genzel, Y.; Liu, X.; Wen-Song, T.; Reichl, U.: Efficient influenza virus production: a MDCK-based high-cell-density process. Vaccine Technology VII, Mont Tremblant, Canada (2018)
  4. 47.
    Poster
    Coronel, J.; Behrendt, I.; Bürgin, T.; Anderlei, T.; Sandig, V.; Genzel, Y.; Reichl, U.: Orbital shaken bioreactor for influenza A virus production in high cell density cultivations. Vaccine Technology VII, Mont Tremblant, Canada (2018)
  5. 48.
    Poster
    Hoffmann, M.; Bartels, M.F.; Noor, S.I.; Hennig, R.; Pioch, M.; Reichl, U.; Strahl, S.; Rapp, E.: Unravelling the Interplay between Protein O-Mannosylation and N-Glycosylation - A Glycomic and Glycoproteomic Study of Human N-Cadherin. DFG FOR 2509 Meeting, Höchst (Odenwald), Germany (2018)
  6. 49.
    Poster
    Laske, T.; Bachmann, M.; Dostert, M.; Frensing, T.; Karlas, A.; Wirth, D.; Reichl, U.: Modeling reveals changes in key parameters of infuenza A virus replication in engineered cell lines. 11th Annual International Conference on Systems Biology of Human Diseases, Los Angeles, USA (2018)
  7. 50.
    Poster
    Nikolay, A.: CCE: The EB66 (R) Cell line for Yellow Fever Vaccine procustion at high cell concentrations. Cell Culture Engineering XVI, Tampa, Florida, USA (2018)
 
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