Mathematical Modeling Approaches

Mathematical Modeling Approaches


Mathematical modeling plays a crucial role in analyzing and understanding biological systems. Even in well-established culture systems for manufacturing of biologicals there is much to be learned about the molecular biological properties of production cell lines, the dynamics of cell growth and product formation, and the complex interaction of cells with their physicochemical environment in a bioreactor. Combined with results from extensive experimental investigations ranging from the cellular to the bioprocess level, mathematical models not only help to explain basic system’s properties but also support the detailed analysis of its behavior and the optimization of the overall process.

Supported by:

Finished grant programs:

Defense Advanced Research Projects Agency (DARPA): INTERCEPT program
(cooperative agreements: W911NF-17-2-0012 and DARPA-16-35-INTERCEPT-FP-018)
Started: 01.05.2017
Ended: 31.12.2021

Bundesministerium für Bildung und Forschung (BMBF): "CellSys - Cell Line Development by Systems Biology"
(Grant Agreement No. 0316189A)
Started: 01.01.2013
Ended: 31.08.2016


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