Publications BPE group

Alcalá Orozco, E. A.; Grote, V.; Fiebig, T.; Klamt, S.; Reichl, U.; Rexer, T.: A Cell‐Free Multi‐enzyme Cascade Reaction for the Synthesis of CDP‐Glycerol. ChemBioChem: A European Journal of Chemical Biology 24 (21), e202300463 (2023)

Burock, R.; Cajic, S.; Hennig, R.; Buettner, F. F. R.; Reichl, U.; Rapp, E.: Reliable N-Glycan Analysis–Removal of Frequently Occurring Oligosaccharide Impurities by Enzymatic Degradation. Molecules 28 (4), 1843 (2023)

Cajic, S.; Hennig, R.; Grote, V.; Reichl, U.; Rapp, E.: Removable Dyes—The Missing Link for In-Depth N-glycan Analysis via Multi-Method Approaches. Engineering 26, pp. 132 - 150 (2023)

Dogra, T.; Pelz, L.; Boehme, J. D.; Küchler, J.; Kershaw, O.; Marichal-Gallardo, P.; Baelkner, M.; Hein, M. D.; Gruber, A. D.; Benndorf, D. et al.; Genzel, Y.; Bruder, D.; Kupke, S. Y.; Reichl, U.: Generation of “OP7 chimera” defective interfering influenza A particle preparations free of infectious virus that show antiviral efficacy in mice. Scientific Reports 13, 20936 (2023)

Göbel, S.; Jaén, K. E.; Dorn, M.; Neumeyer, V.; Jordan, I.; Sandig, V.; Reichl, U.; Altomonte, J.; Genzel, Y.: Process intensification strategies toward cell culture‐based high‐yield production of a fusogenic oncolytic virus. Biotechnology and Bioengineering 120 (9), pp. 2639 - 2657 (2023)

Göbel, S.; Jaén, K. E.; Fernandes, R. P.; Reiter, M.; Altomonte, J.; Reichl, U.; Genzel, Y.: Characterization of a quail suspension cell line for production of a fusogenic oncolytic virus. Biotechnology and Bioengineering 120, pp. 3335 - 3346 (2023)

Hassa, J.; Tubbesing, T. J.; Maus, I.; Heyer, R.; Benndorf, D.; Effenberger, M.; Henke, C.; Osterholz, B.; Beckstette, M.; Pühler, A. et al.; Sczyrba, A.; Schlüter, A.: Uncovering Microbiome Adaptations in a Full-Scale Biogas Plant: Insights from MAG-Centric Metagenomics and Metaproteomics. Microorganisms 11 (10), 2412 (2023)

Hein, M. D.; Kazenmaier, D.; van Heuvel, Y.; Dogra, T.; Cattaneo, M.; Kupke, S. Y.; Stitz, J.; Genzel, Y.; Reichl, U.: Production of retroviral vectors in continuous high cell density culture. Applied Microbiology and Biotechnology 107, pp. 5947 - 5961 (2023)

Hussnaetter, K. P.; Palm, P.; Pich, A.; Franzreb, M.; Rapp, E.; Elling, L.: Strategies for Automated Enzymatic Glycan Synthesis (AEGS). Biotechnology Advances 67, 108208 (2023)

Küchler, J.; Willenbücher, K.; Reiß, E.; Nuß, L.; Conrady, M.; Ramm, P.; Schimpf, U.; Reichl, U.; Szewzyk, U.; Benndorf, D.: Degradation Kinetics of Lignocellulolytic Enzymes in a Biogas Reactor Using Quantitative Mass Spectrometry. Fermentation 9 (1), 67 (2023)

Morticelli, L.; Rossdam, C.; Cajic, S.; Böthig, D.; Magdei, M.; Tuladhar, S. R.; Petersen, B.; Fischer, K.; Rapp, E.; Korossis, S. et al.; Haverich, A.; Schnieke, A.; Niemann, H.; Buettner, F. F. R.; Hilfiker, A.: Genetic knockout of porcineGGTA1orCMAH/GGTA1is associated with the emergence of neo‐glycans. Xenotransplantation 30 (4), e12804 (2023)

Offersgaard, A.; Duarte Hernandez, C. R.; Feng, S.; Marichal-Gallardo, P.; Holmbeck, K.; Pihl, A. F.; Fernandez-Antunez, C.; Peña Alzua, G.; Top Hartmann, K.; Pham, L. V. et al.; Zhou, Y.; Anbro Gammeltoft, K.; Fahnøe, U.; Schneider, U. V.; Pedersen, G. K.; Jensen, H. E.; Pravsgaard Christensen, J.; Ramirez, S.; Bukh, J.; Gottwein, J. M.: An inactivated SARS-CoV-2 vaccine induced cross-neutralizing persisting antibodies and protected against challenge in small animals. iScience 26 (2), 105949 (2023)

Pelz, L.; Piagnani, E.; Marsall, P.; Wynserski, N.; Hein, M. D.; Marichal-Gallardo, P.; Kupke, S. Y.; Reichl, U.: Broad-Spectrum Antiviral Activity of Influenza A Defective Interfering Particles against Respiratory Syncytial, Yellow Fever, and Zika Virus Replication In Vitro. Viruses 15 (9), 1872 (2023)

Trbojević-Akmačić, I.; Vučković, F.; Pribić, T.; Vilaj, M.; Černigoj, U.; Vidič, J.; Šimunović, J.; Kępka, A.; Kolčić, I.; Klarić, L. et al.; Novokmet, M.; Pučić-Baković, M.; Rapp, E.; Štrancar, A.; Polašek, O.; Wilson, J. F.; Lauc, G.: Comparative analysis of transferrin and IgG N-glycosylation in two human populations. Communications Biology 6, 312 (2023)

van Heuvel, Y.; Schatz, S.; Hein, M.; Dogra, T.; Kazenmaier, D.; Tschorn, N.; Genzel, Y.; Stitz, J.: Novel suspension retroviral packaging cells generated by transposition using transposase encoding mRNA advance vector yields and enable production in bioreactors. Frontiers in Bioengineering and Biotechnology 11, 1076524 (2023)

Wenzel, L.; Hoffmann, M.; Rapp, E.; Rexer, T.; Reichl, U.: Cell-free N-glycosylation of peptides using synthetic lipid-linked hybrid and complex N-glycans. Frontiers in Molecular Biosciences 10, 1266431 (2023)

Göbel, S.; Pelz, L.; Reichl, U.; Genzel, Y.: Upstream processing for viral vaccines - Process intensification. In: Bioprocessing of Viral Vaccines, 1st edition Ed., pp. 137 - 174 (Eds. Kamen, A.; Cervera, L.). CRC Press, Boca Raton (2023)

Pelz, L.; Göbel, S.; Jaen , K.; Reichl, U.; Genzel, Y.: Upstream processing for viral vaccines – General aspects. In: Bioprocessing of Viral Vaccines, 1st edition Ed., pp. 79 - 136 (Eds. Kamen , A.; Cervera , L.). CRC Press, Boca Raton (2023)

Morticelli, L.; Rossdam, C.; Cajic, S.; Böthig, D.; Magdei, M.; R Tuladhar, S.; Petersen, B.; Fischer, K.; Rapp, E.; Korossis, S. et al.; Haverich, A.; Schnieke, A.; Niemann, H.; Buettner, F.; Hilfiker, A.: Genetic knockout of porcine GGTA1 or CMAH/GGTA1 is associated with the emergence of neo-glycans. In Transplantation, 107 (10), p. 177 - 177. IPITA-IXA-CTRMA 2023 Joint Congress, San Diego, USA, October 26, 2023 - October 29, 2023. Lippincott Williams & Wilkins, Baltimore (2023)

Alcalá Orozco, E. A.; Huber, N.; Klamt, S.; Rexer, T.; Reichl, U.: A cell-free enzymatic cascade for the synthesis of GDP-fucose - modeling and optimization. GlycoBioTec 2023, Berlin, Germany (2023)

Alcalá Orozco, E. A.; Huber, N.; Klamt, S.; Rexer, T.; Reichl, U.: Development of a cell-free enzymatic cascade for the synthesis of GDP-fucose - modeling and optimization. GlycoBioTec Symposium 2023, Berlin, Germany (2023)

Alcalá Orozco, E. A.; Huber, N.; Klamt, S.; Rexer, T.; Reichl, U.: A cell-free enzymatic cascade for the synthesis of GDP-fucose - modeling and optimization. 3^rd Japan-Switzerland-Germany Workshop on Biocatalysis and Bioprocess Development , Aichi (Japan) (2023)

Dogra, T.; Pelz, L.; Boehme, J. D.; Baelkner, M.; Kershaw, O.; Marichal-Gallardo, P.; Gruber, A. D.; Genzel, Y.; Bruder, D.; Kupke, S. Y. et al.; Reichl, U.: Genetically engineered defective interfering particles of influenza A virus for antiviral treatment and vaccination. 17^th Vaccine Congress, Glasgow (Scotland) (2023)

Dogra, T.; Pelz, L.; Rüdiger, D.; Kupke, S. Y.; Reichl, U.: Reverse genetics for Influenza a virus to generate genetically engineered defective interfering particles for antiviral treatment and vaccination. Vir-AI-DIP Workshop , Hamburg (Germany) (2023)

Genzel, Y.: ESACT Course on Cell Culture-based Viral Vaccines (8^th Edition): Exercise on vaccine design. ESACT Course 2023, Llafranc (Spain) (2023)

Genzel, Y.: ESACT Course on Cell Culture-based Viral Vaccines (8^th Edition): Overview on COVID-19 candidate vaccines. Introduction Exercise. ESACT Course 2023, Llafranc (Spain) (2023)

Genzel, Y.: ESACT Course on Cell Culture-based Viral Vaccines (8^th Edition):Upstream Process Intensification. ESACT Course 2023, Llafranc (Spain) (2023)

Genzel, Y.: ESACT Course on Cell Culture-based Viral Vaccines (8^th Edition):Upstream Process Development - From Master Seed to Production. ESACT Course 2023, Llafranc (Spain) (2023)

Genzel, Y.; Zinnecker, T. M.; Göbel, S.; Reichl, U.: Intensified cell-based virus production: A process development challenge for multiple cell-virus combinations. 16^th PEACe Conference, Sitges (Spain) (2023)

Genzel, Y.; Zinnecker, T. M.; Göbel, S.; Reichl, U.: Next-Generation Virus Production: From Clone, to AMBR, to Perfusion and Very High Virus Yield. International Society for Vaccines (ISV) Annual Congress, Lausanne (Switzerland) (2023)

Genzel, Y.; Zinnecker, T. M.; Göbel, S.; Reichl, U.: Increase in supply through use of new technologies for high yield vaccines. Flanders Vaccine, Brussels (Belgium) (2023)

Göbel, S.; Dallmeier, K.; Jordan, I.; de Jong, J.; Reichl, U.; Genzel, Y.: Intensified production for a yellow fever - ZIKA virus vaccine candicate. Democratization of biotherapies: new manufacturing modalities and intensification's, Oxford, UK (2023)

Göbel, S.; Jaén, K. E.; Pelz, L.; Reiter , M.; Altomonte, J.; Reichl, U.; Genzel, Y.: Intensifiying OSB processes for high titer virus production. 5^th large scale meeting: Orbital shaken bioreactors, Girona (Spain) (2023)

Hellwig, P.; Kautzner, D.; Benndorf, D.; Reichl, U.: Identification of newly synthesized proteins in microbial communities using BONCAT and click chemistry. 5^th International Metaproteomics Symposium, Avignon (France) (2023)

Küchler, J.; Opitz, P.; Rüdiger, D.; Kupke, S. Y.; Genzel, Y.; Benndorf, D.; Reichl, U.: Absolute quantification of influenza A virus proteins during single-round replication in different host cells. 6^th Workshop on Virus Dynamics, Nagoya (Japan) (2023)

Kupke, S. Y.; Dogra, T.; Pelz, L.; Hein, M. D.; Ndeir, N.; Rand, U.; Boehme, J.; Baelkner, M.; Kershaw, O.; Winkler, M. et al.; Cicin-Sain, L.; Bruder, D.; Pöhlmann, S.; Reichl, U.: Influenza A virus defective interfering particles as antiviral agents. 32^nd Annual Meeting of the Society for Virology (GfV), Ulm (Germany) (2023)

Nguyen, R. T.: Precision Biotransformation: Game-changer in Human Milk Oligosaccharides Production. Future Food-tech, London (UK) (2023)

Pelz, L.; Dogra, T.; Boehme, J.D.; Hein, M. D.; Marichal-Gallardo, P.; Genzel, Y.; Bruder, D.; Kupke, S. Y.; Reichl, U.: Influenza A virus OP7 defective interfering particles: Cell culture-based production and antiviral efficacy in vivo. Cell Culture Engineering (CCE) XVIII , Cancun (Mexico) (2023)

Pelz, L.; Genzel, Y.; Kupke, S. Y.; Reichl, U.: In-depth characterization and cell culture-based production of influenza A virus defective interfering particles. ACTIP fellowship session, Dublin (Ireland) (2023)

Pelz, L.; Rüdiger, D.; Dogra, T.; Alnaji, F. D.; Genzel, Y.; Brooke, C. B.; Kupke, S. Y.; Reichl, U.: Semi-continuous Propagation of Influenza A Virus and Its Defective Interfering Particles: Analyzing the Dynamic Competition To Select Candidates for Antiviral Therapy. Vir-AI-DIP Workshop, Hamburg (Germany) (2023)

Rexer, T.: eversyn - Delivering bioactive sugars at scale for nutrition & biopharma. Biofit 13^th Edidion, Marseille (France) (2023)

Rexer, T.: eversyn - Delivering bioactive sugars at scale for nutrition & biopharma. Pharmedi | Pharmed & Healthcare Vietnam 2023, Ho Chi Minh City (Vietnam) (2023)

Rexer, T.; Hoang Son, T.; Alcalá Orozco, E. A.; Juárez-Osorio, M.; Kleeberg, S.; Reichl, U.: Activated sugar for oligosaccharides synthesis. GlycoBioTec 2023, Berlin, Germany (2023)

Rüdiger, D.; Küchler, J.; Piasecka, J.; Pontes, C.; Kupke, S. Y.; Reichl, U.: OP7, a defective interfering particle with mutations: in vitro infection experiments, intracellular model, impact of mutations and mode of antiviral action. 6^th Workshop on Virus Dynamics, Nagoya (japan) (2023)

Rüdiger, D.; Pelz, L.; Hein, M. D.; Kupke, S. Y.; Reichl, U.: Multiscale model of influenza A virus and defective interfering particle co-infection in animal cell culture. Vir-AI-DIP Workshop, Hamburg (Germany) (2023)

Wenzel, L.; Rexer, T.; Reichl, U.: Synthesis of Synthetic Lipid-Linked Oligosaccharides for In-Vitro Glycoengineering of Hemagglutinin Peptides by a Cell-Free, Multi-Enzyme Cascade. GlycoBioTec 2023, Berlin, Germany (2023)

Wenzel, L.; Ruhnau, J.; Rexer, T.; Reichl, U.: Chemoenzymatic glycosylation of polypeptides using eukaryotic oligosaccharyltransferase and synthetic lipid-linked glycans. Glyco26, Taipei (Taiwan) (2023)

Zinnecker, T. M.; Badri, N.; Araujo, D.; Hinkelmann, A.; Thiele, K.; Reichl, U.; Genzel, Y.: Novel approach towards vaccine manufacturing: from single-cell cloning to high-yielding influenza virus production. 4^th Global Bioprocessing, Bioanalytics and ATMP Manufacturing Congress, Dublin (Ireland) (2023)

Zinnecker, T. M.; Badri, N.; Araujo, D.; Hinkelmann, A.; Thiele, K.; Reichl, U.; Genzel, Y.: A quest for the best influenza producing clonal MDCK cell line: intensifying by design of experiments, ambr15 and bench-top bioreactor cultivations. World Biopharm Forum 2023 - Democratisation of biotherapies: new manufacturing modalities and intensifications, Oxford (United Kingdom) (2023)

Zuniga-Banuelos, F. J.; Hoffmann, M.; Budimir, I.; Reichl, U.; Rapp, E.: New avenues for biomarker discovery in human blood plasma via an improved in-depth analysis of the low-abundant N-glycoproteome. GlycoBioTec 2023, Berlin, Germany (2023)