Head of the Group

Prof. Dr.-Ing. Udo Reichl
Prof. Dr.-Ing. Udo Reichl
Phone: +49 391 6110 201
Fax: +49 391 6110 203
Room: N0.19

Contact Person

Annegret Frauendienst
Phone:+49 391 6110-200Fax:+49 391 6110-203

Group Page

Publications

Publications BPE group

Journal Article (9)

  1. 1.
    Journal Article
    Bock, A.; Möhler, L.; Sann, H.; Schulze-Horsel, J.; Genzel, Y.; Reichl, U.: Growth behaviour of number distributed adherent MDCK cells for optimization in large scale microcarrier cultures. Biotechnology Progress 25 (6), pp. 1717 - 1731 (2009)
  2. 2.
    Journal Article
    Genzel, Y.; Reichl, U.: Continuous cell lines as production system for influenza vaccines. Expert Review of Vaccines 8 (12), pp. 1681 - 1692 (2009)
  3. 3.
    Journal Article
    Lohr, V.; Rath, A.; Genzel, Y.; Jordan, I.; Sandig, V.; Reichl, U.: New avian suspension cell lines provide production of influenza virus and MVA in serum-free media: studies on growth, metabolism and virus propagation. Vaccine 27 (36), pp. 4975 - 4982 (2009)
  4. 4.
    Journal Article
    Opitz, L.; Lehmann, S.; Reichl, U.; Wolff, M. W.: Sulfated membrane adsorbers for economic pseudo-affinity capture of influenza virus particles. Biotechnology and Bioengineering 103 (6), pp. 1144 - 1154 (2009)
  5. 5.
    Journal Article
    Opitz, L.; Hohlweg, J.; Reichl, U.; Wolff, M. W.: Purification of cell culture-derived influenza virus A/Puerto Rico/8/34 by membrane-based immobilized metal affinity chromatography. Journal of Virological Methods 161 (2), pp. 312 - 316 (2009)
  6. 6.
    Journal Article
    Rapp, E.; Charvat, A.; Beinsen, A.; Plessmann, U.; Reichl, U.; Seidel-Morgenstern, A.; Urlaub, H.; Abel, B.: Atmospheric Pressure Free Liquid Infrared MALDI Mass Spectrometry: Toward a combined ESI/MALDI-Liquid Chromatography Interface. Analytical Chemistry 81 (1), pp. 443 - 452 (2009)
  7. 7.
    Journal Article
    Schulze-Horsel, J.; Schulze, M.; Agalaridis, G.; Genzel, Y.; Reichl, U.: Infection dynamics and virus-induced apoptosis in cell culture-based influenza vaccine production – flow cytometry and mathematical modeling. Vaccine 27 (20), pp. 2712 - 2722 (2009)
  8. 8.
    Journal Article
    Schwarzer, J.; Rapp, E.; Hennig, R.; Genzel, Y.; Jordan, I.; Sandig, V.; Reichl, U.: Glycan analysis in cell culture-based influenza vaccine production: Influence of host cell line and virus strain on the glycosylation pattern of viral hemagglutinin. Vaccine 27 (32), pp. 4325 - 4336 (2009)
  9. 9.
    Journal Article
    Vester, D.; Rapp, E.; Gade, D.; Genzel, Y.; Reichl, U.: Quantitative analysis of cellular proteome alterations in human influenza A virus-infected mammalian cell lines. Proteomics 9 (12), pp. 3316 - 3327 (2009)

Meeting Abstract (1)

  1. 10.
    Meeting Abstract
    Öncül, A.; Kalmbach, A.; Genzel, Y.; Reichl, U.; Thevenin, D.: Numerische und experimentelle Untersuchung der Fließbedingungen in Wave-Bioreaktoren. In: Chemie-Ingenieur-Technik, Vol. 81, p. 1241 . ProcessNet-Jahrestagung 2009 und 27. Jahrestagung der Biotechnologen, Mannheim, Germany, September 08, 2009 - September 10, 2009. Verlag Chemie, GmbH, Weinheim, Germany (2009)

Talk (22)

  1. 11.
    Talk
    Janke, R.; Genzel, Y.; Wahl, A.; Reichl, U.: Influence of cell culture medium on the catalytic activity of key enzymes in MDCK cells. 27. Jahrestagung der Biotechnologen, Mannheim, Germany (2009)
  2. 12.
    Talk
    Kröber, T.; Wolff, M.; Hundt, B.; Reichl, U.; Seidel-Morgenstern, A.: Purification of Cell Culture-Derived Influenza Virus using Continuous Simulated Moving Bed Chromatography. ISPPP 2011, Alexandria, USA (2009)
  3. 13.
    Talk
    Lohr, V.; Genzel, Y.; Jordan, I.; Sandig, V.; Reichl, U.: Stoffwechsel und Zellphysiologie aviärer Designerzellen während Wachstum und MVA-Produktion. ProcessNet-Jahrestagung 2009 und 27. Jahrestagung der Biotechnologen, Mannheim, Germany (2009)
  4. 14.
    Talk
    Lohr, V.; Rath, A.; Jordan, I.; Sandig, V.; Genzel, Y.; Reichl, U.: Avian designer cells AGE1.CR: possible candidates for MVA and influenza vaccine production? 21st ESACT Meeting, Dublin, Ireland (2009)
  5. 15.
    Talk
    Öncül, A.; Genzel, Y.; Reichl, U.; Thevenin, D.: Investigation of oxygen transfer process in wave bioreactors using Computational Fluid Dynamics. 5th International Berlin Workshop – IBW5, Berlin, Germany (2009)
  6. 16.
    Talk
    Öncül, A.; Thevenin, D.; Kalmbach, A.; Genzel, Y.; Reichl, U.: Numerical and experimental investigation of flow conditions in wave bioreactors. ProcessNet-Jahrestagung 2009 und 27. Jahrestagung der Biotechnologen, Mannheim, Germany (2009)
  7. 17.
    Talk
    Opitz, L.; Lehmann, S.; Zimmermann, A.; Hohlweg, J.; Reichl, U.; Wolff, M. W.: Affinity capture of cell culture-derived influenza virus particles. Prep 2009, Philadelphia, USA (2009)
  8. 18.
    Talk
    Rapp, E.; Schwarzer, J.; Hennig, R.; Roedig, J.; Reichl, U.: Towards High Throughput Characterization of Glycosylation-Patterns Using a Capillary-DNA-Sequencer. CE in Biotechnology & Pharmaceutical Industries: 11th Symposium on the Practical Applications for the Analysis of Proteins, Nucleotides and Small Molecules (CE Pharm 2009), Boston, MA, USA (2009)
  9. 19.
    Talk
    Rapp, E.: Towards high-throughput characterization of carbohydrates using a capillary-DNA-sequencer. Post-Translational Modifications, Prague, Czech Republic (2009)
  10. 20.
    Talk
    Rapp, E.; Charvat, A.; Beinsen, A.; Reichl, U.; Seidel-Morgenstern, A.; Urlaub, H.; Abel, B.: The Atmospheric Pressure Free Liquid Infrared Matrix Assisted Laser Dispersion Ionisation – A New LC-MS Interface. 18th International Mass Spectrometry Conference, Bremen, Germany (2009)
  11. 21.
    Talk
    Rapp, E.; Schwarzer, J.; Hennig, R.; Genzel, Y.; Reichl, U.: Glycan-analysis in influenza vaccine production based on cgelif: influence of host cell and virus on the glycosylationpattern of viral hemagglutinin. EUROCARB 2009 (15th European Carbohydrate Symposium), Main University Vienna, Austria (2009)
  12. 22.
    Talk
    Rapp, E.; Charvát, A.; Beinsen, A.; Urlaub, H.; Plessmann, U.; Reichl, U.; Seidel-Morgenstern, A.; Abel, B.: Unifying LC-MS Interfaces: The Atmospheric Pressure Free Liquid Infrared Matrix Assisted Laser Dispersion Ionisation. 42. DGMS Jahrestagung, Konstsanz, Germany (2009)
  13. 23.
    Talk
    Rapp, E.: Workflow Optimierung zur Durchsatzsteigerung der CGE-LIF basierten Glykan-Analytik. Meeting with Merck-Serono, Darmstadt, Germany (2009)
  14. 24.
    Talk
    Rapp, E.: Utilizing Capillary Gel Electrophoresis with Laser Induced Fluorescence Detection for Glycan-Fingerprinting of Viral Glycoproteins. Wissenschaftliches Kolloqium an der Charite, Berlin, Germany (2009)
  15. 25.
    Talk
    Reichl, U.: Zellkulture - eine Übersicht. Deutscher Influenza Kongress, Erfurt, Germany (2009)
  16. 26.
    Talk
    Reichl, U.: Dynamics of Influenza Virus replication in Mammalian Cell Culture. Workshop Molecular Interactions, Berlin, Germany (2009)
  17. 27.
    Talk
    Reichl, U.: Dynamics of Influenza Virus Replication and Apotosis in Mammalian Cell Culture Flow Cytometry and Mathematical Modeling. Biochemical Engineering XVI - Past, Present and Future of Biochemical Engineering, Burlington, Canada (2009)
  18. 28.
    Talk
    Reichl, U.: Cell Culture Technology - A New Standard for Influenza Vaccine. 26th International Congress of Chemotherapy, Toronto, Canada (2009)
  19. 29.
    Talk
    Reichl, U.: A Systemsa Perspective of Virus Replication in Mammalian Cell Cultures. Biotechnologisches Kolloquium, Saarbrücken, Germany (2009)
  20. 30.
    Talk
    Reichl, U.: Virus Dynamics in Mammalian Cell Culture. Thematic School of the Epigenomics Project entitled "Modelling of complex biological systems in the context of genomics, Nizza, Italy (2009)
  21. 31.
    Talk
    Wolff, M.; Opitz, L.; Siewert, C.; Petermann, N.; Meininger, M.; Lehmann, S.; Hansen, S.P.; Faber, R.; Reichl, U.: Capture of cell culture-derived virus particles by affinity membrane adsorbers. Vaccines Europe, Brussels, Belgium (2009)
  22. 32.
    Talk
    Wolff, M.; Opitz, L.; Siewert, C.; Petermann, N.; Meininger, M.; Lehmann, S.; Hansen, S.P.; Faber, R.; Reichl, U.: Membrane adsorbers to capture cell culture derived virus particles. 29th International Symposium & Exhibit on the Separation of Proteins, Peptides and Polynucleotides, Delray Beach, Florida, USA (2009)

Poster (30)

  1. 33.
    Poster
    Freund, S.; Sandig, V.; Rose, T.; Reichl, U.: Characterization of batch cultivations of a new human suspension cell line. BioSys2009, Hamburg (2009)
  2. 34.
    Poster
    Genzel, Y.; Behrendt, I.; Scharfenberg, K.; Reichl, U.: Evaluation of a new suspension MDCK cell line for influenza vaccine production. 21st ESACT Meeting, Dublin, Ireland (2009)
  3. 35.
    Poster
    Heynisch, B.; Seitz, C.; Frensing, T.; Genzel, Y.; Reichl, U.: Virus-host cell interactions in a bioprocess for influenza vaccine production - characterization of antiviral signaling pathways. ProcessNet-Jahrestagung 2009 und die 27.Jahrestagung der Biotechnologen , Mannheim, Germany (2009)
  4. 36.
    Poster
    Heynisch, B.; Seitz, C.; Frensing, T.; Genzel, Y.; Reichl, U.: Analysis of antiviral signaling cascades in a bioprocess for influenza vaccine production. 21st ESACT Meeting, Dublin, Ireland (2009)
  5. 37.
    Poster
    Heynisch, B.; Seitz, C.; Frensing, T.; Genzel, G.; Reichl, U.: Systems biology of influenza virus-host cell interaction in a bioprocess for vaccine production. German Symposium on Systems Biology 2009, Heidelberg, Germany (2009)
  6. 38.
    Poster
    Heynisch, B.; Schulze-Horsel, J.; Frensing, T.; Genzel, Y.; Reichl, U.: Analysis of Signaling Cascades and Host Cell Defense in a Bioprocess for Influenza Vaccine Production. 19th Annual Meeting of the German Society for Virology 2009, Leipzig, Germany (2009)
  7. 39.
    Poster
    Janke, R.; Genzel, Y.; Wahl, A.; Reichl, U.: Catalytic activity changes of key enzymes in MDCK cells under different growth conditions. 21st ESACT Meeting, Dublin, Ireland (2009)
  8. 40.
    Poster
    Janke, R.; Genzel, Y.; Wahl, A.; Reichl, U.: A high-throughput platform to measure key enzyme activities in mammalian cells. German Symposium on Systems Biology, Heidelberg, Germany (2009)
  9. 41.
    Poster
    Kremling, A.; Janke, R.; Genzel, Y.; Wahl, A.; Reichl, U.: WPT7: Model Validation, Parameter Analysis and Experimental Design. Part I: Parameter estimation and parameter confidence intervalls. Part II: Key enzyme activities in central carbon metabolism of mammalian cells. Evaluation and Status Seminar FORSYS 2009, Heidelberg, Germany (2009)
  10. 42.
    Poster
    Kröber, T.; Wolff, M.; Hebel, K.; Brunner-Weinzierl, M.; Reichl, U.: Particulate Formulation of Influenza Virus Antigen in the Form of ISCOMs. ISPPP 2009, Delray Beach, Florida, USA (2009)
  11. 43.
    Poster
    Kröber, T.; Wolff, M. W.; Lehmann, S.; Zimmermann, A.; Reichl, U.: Accounting for the Entire Influenza Hemagglutinin During a Flu Vaccine Production Process. 21st ESACT Meeting, Dublin, Ireland (2009)
  12. 44.
    Poster
    Lagoda, A.; Hoffmann, D.; Vester, D.; Bettenbrock, K.; Genzel, Y.; Reichl, U.: Realtime-PCR-assay for the quantitative analysis of human influenza A virus replication: validation of an assay for vRNA, cRNA \& mRNA polarity specific primers. Dechema 2009 Event, Mannheim, Germany (2009)
  13. 45.
    Poster
    Lohr, V.; Genzel, Y.; Jordan, I.; Sandig, V.; Reichl, U.: Characterization of avian designer cells as substrates for MVA production. 21st ESACT Meeting, Dublin, Ireland (2009)
  14. 46.
    Poster
    Medger, A.; Miehe, K.; Bettenbrock, K.: Investigation of the Escherichia coli lac operon on population and on single cell level. FEMS Meeting 2009, Götheburg, Schweden (2009)
  15. 47.
    Poster
    Medger, A.; Miehe, K.; Bettenbrock, K.: Investigations of the Escherichia coli lac operon. German Symposium on Systems Biology, Heidelberg, Germany (2009)
  16. 48.
    Poster
    Rath, A.; Genzel, Y.; Sandig, V.; Rose, T.; Reichl, U.: Strategies For Batch Cultivation Of Two New Human Suspension Cell Lines: Culture Conditions And Cellular Metabolism. BioSys2009, Hamburg, Germany (2009)
  17. 49.
    Poster
    Rath, A.; Genzel, Y.; Sandig, V.; Rose, T.; Reichl, U.: A Novel Human Designer Cell Line: Metabolism During Cell Growth. ProcessNet-Jahrestagung 2009 und 27. Jahrestagung der Biotechnologen, Mannheim, Germany (2009)
  18. 50.
    Poster
    Rath, A.; Genzel, Y.; Sandig, V.; Rose, T.; Reichl, U.: Cell Growth and Metabolism of a Novel Human Designer Cell Line. 21st ESACT Meeting, Dublin, Ireland (2009)
 
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