Head of the Group

Prof. Dr.-Ing. Udo Reichl
Prof. Dr.-Ing. Udo Reichl
Phone: +49 391 6110 201
Fax: +49 391 6110 203
Room: N0.19

Contact Person

Annegret Frauendienst
Phone:+49 391 6110-200Fax:+49 391 6110-203

Group Page

Publications

Publications BPE group

Journal Article (224)

  1. Journal Article
    Genzel, Y.; Frensing, T.; Reichl, U.: Herstellung moderner Grippeimpfstoffe: Zellkultur statt Hühnerei. Chemie in unserer Zeit 47 (1), pp. 12 - 22 (2013)
  2. Journal Article
    Hädicke, O.; Lohr, V.; Genzel, Y.; Reichl, U.; Klamt, S.: Evaluating differences of metabolic performances: Statistical methods and their application to animal cell cultivations. Biotechnology and Bioengineering 110 (10), pp. 2633 - 2642 (2013)
  3. Journal Article
    Hanreich, A.; Schimpf, U.; Zakrzewski, M.; Schlüter, A.; Benndorf, D.; Heyer, R.; Rapp, E.; Puhler, A.; Reichl, U.; Klocke, M.: Metagenome and metaproteome analyses of microbial communities in mesophilic biogas-producing anaerobic batch fermentations indicate concerted plant carbohydrate degradation. Systematic and Applied Microbiology 36 (5), pp. 330 - 338 (2013)
  4. Journal Article
    Heldt, S.; Frensing, T.; Pflugmacher, A.; Gröpler, R.; Peschel, B.; Reichl, U.: Multiscale Modeling of Influenza A Virus Infection Supports the Development of Direct-Acting Antivirals. PLoS Computational Biology 9 (11), p. e1003372 (2013)
  5. Journal Article
    Heyer, R.; Kohrs, F.; Benndorf, D.; Rapp, E.; Kausmann, R.; Heiermann, M.; Klocke, M.; Reichl, U.: Metaproteome analysis of the microbial communities in agricultural biogas plants. New biotechnology 30 (6), pp. 614 - 622 (2013)
  6. Journal Article
    Hütter, J.; Rödig, J. V.; Höper, D.; Seeberger, P. H.; Reichl, U.; Rapp, E.; Lepenies, B.: Toward Animal Cell Culture-based Influenza Vaccine Design: Viral Hemagglutinin N-Glycosylation Markedly Impacts Immunogenicity. The Journal of Immunology 190 (1), pp. 220 - 230 (2013)
  7. Journal Article
    Jordan, I.; Lohr, V.; Genzel, Y.; Reichl, U.; Sandig, V.: Elements in the Development of a Production Process for Modified Vaccinia Virus Ankara. Microorganisms 1 (1), pp. 100 - 121 (2013)
  8. Journal Article
    Kluge, S.; Rourou, S.; Vester, D.; Majoul, S.; Benndorf, D.; Genzel, Y.; Rapp, E.; Kallel, H.; Reichl, U.: Proteome analysis of virus-host cell interaction: rabies virus replication in Vero cells in two different media. Applied Microbiology and Biotechnology 97 (12), pp. 5493 - 5506 (2013)
  9. Journal Article
    Kolarich, D.; Rapp, E.; Struwe, W. B.; Haslam, S. M.; Zaia, J.; McBride, R.; Agravat, S.; Campell, M. P.; Kato, M.; Ranzinger, R. et al.; Kettner, C.; York, W. S.: The Minimum Information Required for a Glycomics Experiment (MIRAGE) Project: Improving the Standards for Reporting Mass-spectrometry-based Glycoanalytic Data. Molecular and Cellular Proteomics 12 (4), pp. 991 - 995 (2013)
  10. Journal Article
    Kottler, R.; Mank, M.; Hennig, R.; Müller-Werner, B.; Stahl, B.; Reichl, U.; Rapp, E.: Development of a high-throughput glycoanalysis method for the characterization of oligosaccharides in human milk utilizing multiplexed capillary gel electrophoresis with laser-induced fluorescence detection. Electrophoresis 34 (16), pp. 2323 - 2336 (2013)
  11. Journal Article
    Kröber, T.; Wolff, M. W.; Hundt, B.; Seidel-Morgenstern, A.; Reichl, U.: Continuous purification of influenza virus using simulated moving bed chromatography. Journal of Chromatography A 1307, pp. 99 - 110 (2013)
  12. Journal Article
    Müller, T.; Dürr, R.; Isken, B.; Schulze-Horsel, J.; Reichl, U.; Kienle, A.: Distributed modeling of human influenza a virus-host cell interactions during vaccine production. Biotechnology and Bioengineering 110 (8), pp. 2252 - 2266 (2013)
  13. Journal Article
    Muth, T.; Benndorf, D.; Reichl, U.; Rapp, E.; Martens, L.: Searching for a needle in a stack of needles: challenges in metaproteomics data analysis. Molecular BioSystems 9 (4), pp. 578 - 585 (2013)
  14. Journal Article
    Muth, T.; Peters, J.; Blackburn, J.; Rapp, E.; Martens, L.: ProteoCloud: A full-featured open source proteomics cloud computing pipeline. Journal of Proteomics 88 (Special Issue: New Horizons and Applications for Proteomics [EuPA 2012]), pp. 104 - 108 (2013)
  15. Journal Article
    Neumann, A.; Hoyer, W.; Wolff, M. W.; Reichl, U.; Pfitzner, A.; Roth, B.: New method for density determination of nanoparticles using a CPS disc centrifuge (TM). Colloids and Surfaces B: Biointerfaces 104, pp. 27 - 31 (2013)
  16. Journal Article
    Peschel, B.; Frentzel, S.; Laske, T.; Genzel, Y.; Reichl, U.: Comparison of influenza virus yields and apoptosis-induction in an adherent and a suspension MDCK cell line. Vaccine 31 (48), pp. 5693 - 5699 (2013)
  17. Journal Article
    Rehberg, M.; Ritter, J. B.; Genzel, Y.; Flockerzi, D.; Reichl, U.: The relation between growth phases, cell volume changes and metabolism of adherent cells during cultivation. Journal of Biotechnology 164 (4), pp. 489 - 499 (2013)
  18. Journal Article
    Rödig, J. V.; Rapp, E.; Bohne, J.; Kampe, M.; Kaffka, H.; Bock, A.; Genzel, Y.; Reichl, U.: Impact of Cultivation Conditions on N-glycosylation of Influenza Virus A Hemagglutinin Produced in MDCK Cell Culture. Biotechnology and Bioengineering 110 (6), pp. 1691 - 1703 (2013)
  19. Journal Article
    Rodriguez-Fernandez, M.; Rehberg, M.; Kremling, A.; Banga, J. R.: Simultaneous model discrimination and parameter estimation in dynamic models of cellular systems. BMC Systems Biology 7, 76 (2013)
  20. Journal Article
    Stavenhagen, K.; Hinneburg, H.; Thaysen-Andersen, M.; Hartmann, L.; Silva, D. V.; Fuchser, J.; Kaspar, S.; Rapp, E.; Seeberger, P. H.; Kolarich, D.: Quantitative mapping of glycoprotein micro-heterogeneity and macro-heterogeneity: An evaluation of mass spectrometry signal strengths using synthetic peptides and glycopeptides. Journal of Mass Spectrometry 48 (6), pp. 627 - 639 (2013)
  21. Journal Article
    Tung, S.; Shi, Y.; Wong, K.; Zhu, F.; Gorczynski, R.; Laister, R.; Minden, M.; Blechert, A.-K.; Genzel, Y.; Reichl, U. et al.; Spaner, D. E.: PPARalpha and fatty acid oxidation mediate glucocorticoid resistance in chronic lymphocytic leukemia. Blood 122 (6), pp. 969 - 980 (2013)
  22. Journal Article
    Carrondo, M. J. T.; Alves, P. M.; Carinhas, N.; Glassey, J.; Hesse, F.; Merten, O.-W.; Micheletti, M.; Noll, T.; Oliveira, R.; Reichl, U. et al.; Staby, A.; Teixeira, A. P.; Weichert, H.; Mandenius, C.-F.: How can measurement, monitoring, modeling and control advance cell culture in industrial biotechnology? Biotechnology Journal 7 (12), pp. 1522 - 1529 (2012)
  23. Journal Article
    Hanreich, A.; Heyer, R.; Benndorf, D.; Rapp, E.; Pioch, M.; Reichl, U.; Klocke, M.: Metaproteome analysis to determine the metabolically active part of thermophilic microbial community producing biogas from agricultural biomass. Canadian Journal of Microbiology 58 (7), pp. 917 - 922 (2012)
  24. Journal Article
    Heldt, F. S.; Frensing, T.; Reichl, U.: Modeling the intracellular dynamics of influenza virus replication to understand the control of viral RNA synthesis. Journal of Virology 86 (15), pp. 7806 - 7817 (2012)
  25. Journal Article
    Isken, B.; Genzel, Y.; Reichl, U.: Productivity, apoptosis, and infection dynamics of influenza A/PR/8 strains and A/PR/8-based reassortants. Vaccine 30 (35), pp. 5253 - 5261 (2012)
  26. Journal Article
    Kluge, S.; Hoffmann, M.; Benndorf, D.; Rapp, E.; Reichl, U.: Proteomic tracking and analysis of a bacterial mixed culture. Proteomics 12 (12), pp. 1893 - 1901 (2012)
  27. Journal Article
    Kolmakov, K.; Wurm, C.; Hennig, R.; Rapp, E.; Jakobs, S.; Belov, V. N.; Hell, S. W.: Red-Emitting Rhodamines with Hydroxylated, Sulfonated, and Phosphorylated Dye Residues and Their Use in Fluorescence Nanoscopy. Chemistry - A European Journal 18 (41), pp. 12986 - 12998 (2012)
  28. Journal Article
    Lohr, V.; Genzel, Y.; Jordan, I.; Katinger, D.; Mahr, S.; Sandig, V.; Reichl, U.: Live attenuated influenza viruses produced in a suspension process with avian AGE1.CR.pIX cells. BMC Biotechnology 12, p. 79 (2012)
  29. Journal Article
    Muth, T.; Garcia-Martin, J. A.; Rausell, A.; Juan, D.; Valencia, A.; Pazos, F.: JDet: interactive calculation and visualization of function-related conservation patterns in multiple sequence alignments and structures. Bioinformatics 28 (4), pp. 584 - 586 (2012)
  30. Journal Article
    Platas Barradas, O.; Jandt, U.; Da Minh Phan, L.; Villanueva, M. E.; Schaletzky, M.; Rath, A.; Freund, S.; Reichl, U.; Skerhutt, E.; Scholz, S. et al.; Noll, T.; Sandig, V.; Pörtner, R.; Zeng, A.-P.: Evaluation of criteria for bioreactor comparison and operation standardization for mammalian cell culture. Engineering in Life Sciences 12 (5), pp. 518 - 528 (2012)
  31. Journal Article
    Popov, M.; Nacheva, G.; Reichl, U.; Ivanov, I.: Effect of the 3’-terminal truncation of the human interferon-gamma gene on plasmid segregation in escherichia coli. Biotechnology and Biotechnological Equipment 26 (2), pp. 2930 - 2936 (2012)
  32. Journal Article
    Rapp, E.; Borowiak, M.: Limonade durch Fermentation. Chemie in unserer Zeit 46 (1), pp. 60 - 61 (2012)
  33. Journal Article
    Riedele, C.; Reichl, U.: Time-kill studies with a ceftazidime-treated mixed culture consisting of Pseudomonas aeruginosa, Burkholderia cepacia and Staphylococcus aureus. Engineering in Life Sciences 12 (2), pp. 188 - 197 (2012)
  34. Journal Article
    Rüger, M.; Bensch, G.; Tüngler, R.; Reichl, U.: A Flow Cytometric Method for Viability Assessment of Staphylococcus aureus and Burkholderia cepacia in Mixed Culture. Cytometry Part A 81 A (12), pp. 1055 - 1066 (2012)
  35. Journal Article
    Seitz, C.; Isken, B.; Heynisch, B.; Rettkowski, M.; Frensing, T.; Reichl, U.: Trypsin promotes efficient influenza vaccine production in MDCK cells by interfering with the antiviral host response. Applied Microbiology and Biotechnology 93 (2), pp. 601 - 611 (2012)
  36. Journal Article
    Selman, M. H. J.; Hoffmann, M.; Zauner, G.; McDonnell, L. A.; Balog, C. I. A.; Rapp, E.; Deelder, A. M.; Wuhrer, M.: MALDI-TOF-MS analysis of sialylated glycans and glycopeptides using 4-chloro-α-cyanocinnamic acid matrix. Proteomics 12 (9), pp. 1337 - 1348 (2012)
  37. Journal Article
    Zauner, G.; Hoffmann, M.; Rapp, E.; Koeleman, C. A. M.; Dragan, I.; Deelder, A. M.; Wuhrer, M.; Hensbergen, P. J.: Glycoproteomic Analysis of Human Fibrinogen Reveals Novel Regions of O‑Glycosylation. Journal of Proteome Research 11 (12), pp. 5804 - 5814 (2012)
  38. Journal Article
    Bock, A.; Schulze-Horsel, J.; Schwarzer, J.; Rapp, E.; Genzel, Y.; Reichl, U.: High-density microcarrier cell cultures for influenza virus production. Biotechnology Progress 27 (1), pp. 241 - 250 (2011)
  39. Journal Article
    Frensing, T.; Seitz, C.; Heynisch, B.; Patzina, C.; Kochs, G.; Reichl, U.: Efficient influenza B virus propagation due to deficient interferon-induced antiviral activity in MDCK cells. Vaccine 29 (41), pp. 7125 - 7129 (2011)
  40. Journal Article
    Janke, R.; Genzel, Y.; Händel, N.; Wahl, A.; Reichl, U.: Metabolic adaptation of MDCK cells to different growth conditions: Effects on catalytic activities of central metabolic enzymes. Biotechnology and Bioengineering 108 (11), pp. 2691 - 2704 (2011)
  41. Journal Article
    Kalmbach, A.; Bordas, R.; Öncül, A.; Thévenin, D.; Genzel, Y.; Reichl, U.: Experimental Characterization of Flow Conditions in 2- and 20-L Bioreactors with Wave-Induced Motion. Biotechnology Progress 27 (2), pp. 402 - 409 (2011)
  42. Journal Article
    Kolvenbach, B. A.; Lenz, M.; Benndorf, D.; Rapp, E.; Fousek, J.; Vlcek, C.; Schäffer, A.; Gabriel, F. L.; Kohler, H.-P. E.; Corvini, P. F.: Purification and characterization of hydroquinone dioxygenase from Sphingomonas sp. strain TTNP3. AMB Express 1, p. 8 (2011)
  43. Journal Article
    Kuhn, R.; Benndorf, D.; Rapp, E.; Reichl, U.; Palese, L.; Pollice, A.: Metaproteome analysis of sewage sludge from membrane bioreactors. Proteomics 11 (13), pp. 2738 - 2744 (2011)
  44. Journal Article
    Petiot, E.; Jacob, D.; Lanthier, S.; Lohr, V.; Ansorge, S.; Kamen, A. A.: Metabolic and Kinetic analyses of influenza production in perfusion HEK293 cell culture. BMC Biotechnology 11 (84), pp. 1 - 12 (2011)
  45. Journal Article
    Popov, M.; Petrov, S. A.; Nacheva, G.; Ivanov, I.; Reichl, U.: Effects of a recombinant gene expression on ColE1-like plasmid segregation in Escherichia coli. BMC Biotechnology 11 (1), p. 18 (2011)
  46. Journal Article
    Riedele, C.; Reichl, U.: Inter-Species Effects in Ceftazidime-Treated Mixed Culture of Pseudomonas aeruginosa, Burkholderia cepacia and Staphylococcus aureus – Analysis on the Single Species Level. Journal of Antimicrobial Chemotherapy 66 (1), pp. 138 - 145 (2011)
  47. Journal Article
    Rödig, J.; Rapp, E.; Djeljadini, S.; Lohr, V.; Genzel, Y.; Jordan, I.; Sandig, V.; Reichl, U.: Impact of Influenza Virus Adaptation Status on HA N-Glycosylation Patterns in Cell Culture-Based Vaccine Production. Journal of Carbohydrate Chemistry 30 (4-6), pp. 281 - 290 (2011)
  48. Journal Article
    Roedig, J.; Rapp, E.; Höper, D.; Genzel, Y.; Reichl, U.: Impact of Host Cell Line Adaptation on Quasispecies Composition and Glycosylation of Influenza A Virus Hemagglutinin. PLoS One 6 (12), p. e27989 (2011)
  49. Journal Article
    Schmidt, J. K.; Riedele, C.; Regestein, L.; Rausenberger, J.; Reichl, U.: A novel concept combining experimental and mathematical analysis for the identification of unknown interspecies effects in a mixed culture. Biotechnology and Bioengineering 108 (8), pp. 1900 - 1911 (2011)
  50. Journal Article
    Wolff, M.; Reichl, U.: Downstream processing of cell culture-derived virus particles. Expert Review of Vaccines 10 (10), pp. 1451 - 1475 (2011)
 
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