Head of the Group

Prof. Dr.-Ing. Udo Reichl
Prof. Dr.-Ing. Udo Reichl
Phone: +49 391 6110 201
Fax: +49 391 6110 203
Room: N0.19

Contact Person

Annegret Frauendienst
Phone:+49 391 6110-200Fax:+49 391 6110-203

Group Page

Publications

Publications BPE group

Journal Article (241)

  1. 101.
    Journal Article
    Kohrs, F.; Heyer, R.; Magnussen, A.; Benndorf, D.; Muth, T.; Behne, A.; Rapp, E.; Kausmann, R.; Heiermann, M.; Klocke, M.: Sample prefractionation with liquid isoelectric focusing enables in depth microbial metaproteome analysis of mesophilic and thermophilic biogas plants. Anaerobe 29, pp. 59 - 67 (2014)
  2. 102.
    Journal Article
    Lohr, V.; Hädicke, O.; Genzel, Y.; Jordan, I.; Buentemeyer, H.; Klamt, S.; Reichl, U.: The avian cell line AGE1.CR.pIX characterized by metabolic flux analysis. BMC Biotechnology 14, p. 72 (2014)
  3. 103.
    Journal Article
    Muth, T.; Weilnböck, L.; Rapp, E.; Huber, C. G.; Martens, L.; Vaudel, M.; Barnsnes, H.: DeNovoGUI: An Open Source Graphical User Interface for de Novo Sequencing of Tandem Mass Spectra. Journal of Proteome Research 13 (2), pp. 1143 - 1146 (2014)
  4. 104.
    Journal Article
    Rath, A.; Rehberg, M.; Janke, R.; Genzel, Y.; Scholz, S.; Noll, T.; Rose, T.; Sandig, V.; Reichl, U.: The influence of cell growth and enzyme activity changes on intracellular metabolite dynamics in AGE1.HN.AAT cells. Journal of Biotechnology 178, pp. 43 - 53 (2014)
  5. 105.
    Journal Article
    Rehberg, M.; Rath, A.; Ritter, J.; Genzel, Y.; Reichl, U.: Changes in intracellular metabolite pools during growth of adherent MDCK cells in two different media. Applied Microbiology and Biotechnology 98 (1), pp. 385 - 397 (2014)
  6. 106.
    Journal Article
    Rehberg, M.; Ritter, J.; Reichl, U.: Glycolysis Is Governed by Growth Regime and Simple Enzyme Regulation in Adherent MDCK Cells. PLoS Computational Biology 10 (10), p. e1003885 (2014)
  7. 107.
    Journal Article
    Rüger, M.; Ackermann, M.; Reichl, U.: Species-specific viability analysis of Pseudomonas aeruginosa, Burkholderia cepacia and Staphylococcus aureus in mixed culture by flow cytometry. BMC Microbiology 14, p. 56 - 56 (2014)
  8. 108.
    Journal Article
    Tapia, F.; Vogel, T.; Genzel, Y.; Behrendt, I.; Hirschel, M.; Gangemi, J. D.; Reichl, U.: Production of high-titer human influenza A virus with adherent and suspension MDCK cells cultured in a single-use hollow fiber bioreactor. Vaccine 32 (8), pp. 1003 - 1011 (2014)
  9. 109.
    Journal Article
    Wang, W.; Wolff, M. W.; Reichl, U.; Sundmacher, K.: Avidity of influenza virus: Model-based identification of adsorption kinetics from surface plasmon resonance experiments. Journal of Chromatography A 1326, pp. 125 - 129 (2014)
  10. 110.
    Journal Article
    Weigel, T.; Solomaier, T.; Peuker, A.; Pathapati, T.; Wolff, M. W.; Reichl, U.: A flow-through chromatography process for influenza A and B virus purification. Journal of Virological Methods 207, pp. 45 - 53 (2014)
  11. 111.
    Journal Article
    York, W.S.; Agravat, S.; Aoki-Kinoshita, K.F.; Mcbride, R.; Campell, F.; Castello, C.E.; Dell, A.; Feizi, T.; Haslam, S.M.; Karlsson, N. et al.; Khoo, K.-H.; Kolarich, D.; Liu, Y.; Novotny, M.; Packer, N.H.; Paulson, J.C.; Rapp, E.; Ranzinger, R.; Rudd, P.M.; Smith, D.F.; Struwe, W.B.; Tiemeyer, M.; Wells, L.; Zaia, J.; Kettner, C.: MIRAGE: The minimum information required for a glycomics experiment. Glycobiology 24 (5), pp. 402 - 406 (2014)
  12. 112.
    Journal Article
    Bakovic, M.P.; Selman, M.H.J.; Hoffmann, M.; Rudan, I.; Campbell, H.; Deelder, A.M.; Lauc, G.; Wuhrer, M.: High-Throughput IgG Fc N-Glycosylation Profiling by Mass Spectrometry of Glycopeptides. Journal of Proteome Research 12 (2), pp. 821 - 831 (2013)
  13. 113.
    Journal Article
    Behne, A.; Muth, T.; Borowiak, M.; Reichl, U.; Rapp, E.: glyXalign: High-throughput migration time alignment preprocessing of electrophoretic data retrieved via multiplexed capillary gel electrophoresis with laser-induced fluorescence detection-based glycoprofiling. Electrophoresis 34 (16), pp. 2311 - 2315 (2013)
  14. 114.
    Journal Article
    Borchers, S.; Freund, S.; Rath, A.; Streif, S.; Reichl, U.; Findeisen, R.: Identification of Growth Phases and Influencing Factors in Cultivations with AGE1.HN Cells Using Set-Based Methods. PLoS One 8 (8), p. e68124 (2013)
  15. 115.
    Journal Article
    Bunz, S.-C.; Rapp, E.; Neusüss, C.: Capillary Electrophoresis/Mass Spectrometry of APTS-Labeled Glycans for the Identification of Unknown Glycan Species in Capillary Electrophoresis/Laser-Induced Fluorescence Systems. Analytical Chemistry 85 (21), pp. 10218 - 10224 (2013)
  16. 116.
    Journal Article
    Frensing, T.; Heldt, S.; Pflugmacher, A.; Behrendt, I.; Jordan, I.; Flockerzi, D.; Genzel, Y.; Reichl, U.: Continuous Influenza Virus Production in Cell Culture Shows a Periodic Accumulation of Defective Interfering Particles. PLoS One 8 (9), p. e72288 (2013)
  17. 117.
    Journal Article
    Freund, S.; Rath, A.; Barradas, O. P.; Skerhutt, S.; Scholz, S.; Niklas, J.; Sandig, V.; Rose, T.; Heinzle, E.; Noll, T. et al.; Pörtner, R.; Zeng, A. P.; Reichl, U.: Batch-to-batch variability of two human designer cell lines - AGE1.HN and AGE1.HN.AAT - carried out by different laboratories under defined culture conditions using a mathematical model. Engineering in Life Sciences 13 (6), pp. 580 - 592 (2013)
  18. 118.
    Journal Article
    Genzel, Y.; Behrendt, I.; Rödig, J.; Rapp, E.; Kueppers, C.; Kochanek, S.; Schiedner, G.; Reichl, U.: CAP, a new human suspension cell line for influenza virus production. Applied Microbiology and Biotechnology 97 (1), pp. 111 - 122 (2013)
  19. 119.
    Journal Article
    Genzel, Y.; Frensing, T.; Reichl, U.: Herstellung moderner Grippeimpfstoffe: Zellkultur statt Hühnerei. Chemie in unserer Zeit 47 (1), pp. 12 - 22 (2013)
  20. 120.
    Journal Article
    Hädicke, O.; Lohr, V.; Genzel, Y.; Reichl, U.; Klamt, S.: Evaluating differences of metabolic performances: Statistical methods and their application to animal cell cultivations. Biotechnology and Bioengineering 110 (10), pp. 2633 - 2642 (2013)
  21. 121.
    Journal Article
    Hanreich, A.; Schimpf, U.; Zakrzewski, M.; Schlüter, A.; Benndorf, D.; Heyer, R.; Rapp, E.; Puhler, A.; Reichl, U.; Klocke, M.: Metagenome and metaproteome analyses of microbial communities in mesophilic biogas-producing anaerobic batch fermentations indicate concerted plant carbohydrate degradation. Systematic and Applied Microbiology 36 (5), pp. 330 - 338 (2013)
  22. 122.
    Journal Article
    Heldt, S.; Frensing, T.; Pflugmacher, A.; Gröpler, R.; Peschel, B.; Reichl, U.: Multiscale Modeling of Influenza A Virus Infection Supports the Development of Direct-Acting Antivirals. PLoS Computational Biology 9 (11), p. e1003372 (2013)
  23. 123.
    Journal Article
    Heyer, R.; Kohrs, F.; Benndorf, D.; Rapp, E.; Kausmann, R.; Heiermann, M.; Klocke, M.; Reichl, U.: Metaproteome analysis of the microbial communities in agricultural biogas plants. New biotechnology 30 (6), pp. 614 - 622 (2013)
  24. 124.
    Journal Article
    Hütter, J.; Rödig, J. V.; Höper, D.; Seeberger, P. H.; Reichl, U.; Rapp, E.; Lepenies, B.: Toward Animal Cell Culture-based Influenza Vaccine Design: Viral Hemagglutinin N-Glycosylation Markedly Impacts Immunogenicity. The Journal of Immunology 190 (1), pp. 220 - 230 (2013)
  25. 125.
    Journal Article
    Jordan, I.; Lohr, V.; Genzel, Y.; Reichl, U.; Sandig, V.: Elements in the Development of a Production Process for Modified Vaccinia Virus Ankara. Microorganisms 1 (1), pp. 100 - 121 (2013)
  26. 126.
    Journal Article
    Kluge, S.; Rourou, S.; Vester, D.; Majoul, S.; Benndorf, D.; Genzel, Y.; Rapp, E.; Kallel, H.; Reichl, U.: Proteome analysis of virus-host cell interaction: rabies virus replication in Vero cells in two different media. Applied Microbiology and Biotechnology 97 (12), pp. 5493 - 5506 (2013)
  27. 127.
    Journal Article
    Kolarich, D.; Rapp, E.; Struwe, W. B.; Haslam, S. M.; Zaia, J.; McBride, R.; Agravat, S.; Campell, M. P.; Kato, M.; Ranzinger, R. et al.; Kettner, C.; York, W. S.: The Minimum Information Required for a Glycomics Experiment (MIRAGE) Project: Improving the Standards for Reporting Mass-spectrometry-based Glycoanalytic Data. Molecular and Cellular Proteomics 12 (4), pp. 991 - 995 (2013)
  28. 128.
    Journal Article
    Kottler, R.; Mank, M.; Hennig, R.; Müller-Werner, B.; Stahl, B.; Reichl, U.; Rapp, E.: Development of a high-throughput glycoanalysis method for the characterization of oligosaccharides in human milk utilizing multiplexed capillary gel electrophoresis with laser-induced fluorescence detection. Electrophoresis 34 (16), pp. 2323 - 2336 (2013)
  29. 129.
    Journal Article
    Kröber, T.; Wolff, M. W.; Hundt, B.; Seidel-Morgenstern, A.; Reichl, U.: Continuous purification of influenza virus using simulated moving bed chromatography. Journal of Chromatography A 1307, pp. 99 - 110 (2013)
  30. 130.
    Journal Article
    Müller, T.; Dürr, R.; Isken, B.; Schulze-Horsel, J.; Reichl, U.; Kienle, A.: Distributed modeling of human influenza a virus-host cell interactions during vaccine production. Biotechnology and Bioengineering 110 (8), pp. 2252 - 2266 (2013)
  31. 131.
    Journal Article
    Muth, T.; Benndorf, D.; Reichl, U.; Rapp, E.; Martens, L.: Searching for a needle in a stack of needles: challenges in metaproteomics data analysis. Molecular BioSystems 9 (4), pp. 578 - 585 (2013)
  32. 132.
    Journal Article
    Muth, T.; Peters, J.; Blackburn, J.; Rapp, E.; Martens, L.: ProteoCloud: A full-featured open source proteomics cloud computing pipeline. Journal of Proteomics 88 (Special Issue: New Horizons and Applications for Proteomics [EuPA 2012]), pp. 104 - 108 (2013)
  33. 133.
    Journal Article
    Neumann, A.; Hoyer, W.; Wolff, M. W.; Reichl, U.; Pfitzner, A.; Roth, B.: New method for density determination of nanoparticles using a CPS disc centrifuge (TM). Colloids and Surfaces B: Biointerfaces 104, pp. 27 - 31 (2013)
  34. 134.
    Journal Article
    Peschel, B.; Frentzel, S.; Laske, T.; Genzel, Y.; Reichl, U.: Comparison of influenza virus yields and apoptosis-induction in an adherent and a suspension MDCK cell line. Vaccine 31 (48), pp. 5693 - 5699 (2013)
  35. 135.
    Journal Article
    Rehberg, M.; Ritter, J. B.; Genzel, Y.; Flockerzi, D.; Reichl, U.: The relation between growth phases, cell volume changes and metabolism of adherent cells during cultivation. Journal of Biotechnology 164 (4), pp. 489 - 499 (2013)
  36. 136.
    Journal Article
    Rödig, J. V.; Rapp, E.; Bohne, J.; Kampe, M.; Kaffka, H.; Bock, A.; Genzel, Y.; Reichl, U.: Impact of Cultivation Conditions on N-glycosylation of Influenza Virus A Hemagglutinin Produced in MDCK Cell Culture. Biotechnology and Bioengineering 110 (6), pp. 1691 - 1703 (2013)
  37. 137.
    Journal Article
    Rodriguez-Fernandez, M.; Rehberg, M.; Kremling, A.; Banga, J. R.: Simultaneous model discrimination and parameter estimation in dynamic models of cellular systems. BMC Systems Biology 7, 76 (2013)
  38. 138.
    Journal Article
    Stavenhagen, K.; Hinneburg, H.; Thaysen-Andersen, M.; Hartmann, L.; Silva, D. V.; Fuchser, J.; Kaspar, S.; Rapp, E.; Seeberger, P. H.; Kolarich, D.: Quantitative mapping of glycoprotein micro-heterogeneity and macro-heterogeneity: An evaluation of mass spectrometry signal strengths using synthetic peptides and glycopeptides. Journal of Mass Spectrometry 48 (6), pp. 627 - 639 (2013)
  39. 139.
    Journal Article
    Tung, S.; Shi, Y.; Wong, K.; Zhu, F.; Gorczynski, R.; Laister, R.; Minden, M.; Blechert, A.-K.; Genzel, Y.; Reichl, U. et al.; Spaner, D. E.: PPARalpha and fatty acid oxidation mediate glucocorticoid resistance in chronic lymphocytic leukemia. Blood 122 (6), pp. 969 - 980 (2013)
  40. 140.
    Journal Article
    Carrondo, M. J. T.; Alves, P. M.; Carinhas, N.; Glassey, J.; Hesse, F.; Merten, O.-W.; Micheletti, M.; Noll, T.; Oliveira, R.; Reichl, U. et al.; Staby, A.; Teixeira, A. P.; Weichert, H.; Mandenius, C.-F.: How can measurement, monitoring, modeling and control advance cell culture in industrial biotechnology? Biotechnology Journal 7 (12), pp. 1522 - 1529 (2012)
  41. 141.
    Journal Article
    Hanreich, A.; Heyer, R.; Benndorf, D.; Rapp, E.; Pioch, M.; Reichl, U.; Klocke, M.: Metaproteome analysis to determine the metabolically active part of thermophilic microbial community producing biogas from agricultural biomass. Canadian Journal of Microbiology 58 (7), pp. 917 - 922 (2012)
  42. 142.
    Journal Article
    Heldt, F. S.; Frensing, T.; Reichl, U.: Modeling the intracellular dynamics of influenza virus replication to understand the control of viral RNA synthesis. Journal of Virology 86 (15), pp. 7806 - 7817 (2012)
  43. 143.
    Journal Article
    Isken, B.; Genzel, Y.; Reichl, U.: Productivity, apoptosis, and infection dynamics of influenza A/PR/8 strains and A/PR/8-based reassortants. Vaccine 30 (35), pp. 5253 - 5261 (2012)
  44. 144.
    Journal Article
    Kluge, S.; Hoffmann, M.; Benndorf, D.; Rapp, E.; Reichl, U.: Proteomic tracking and analysis of a bacterial mixed culture. Proteomics 12 (12), pp. 1893 - 1901 (2012)
  45. 145.
    Journal Article
    Kolmakov, K.; Wurm, C.; Hennig, R.; Rapp, E.; Jakobs, S.; Belov, V. N.; Hell, S. W.: Red-Emitting Rhodamines with Hydroxylated, Sulfonated, and Phosphorylated Dye Residues and Their Use in Fluorescence Nanoscopy. Chemistry - A European Journal 18 (41), pp. 12986 - 12998 (2012)
  46. 146.
    Journal Article
    Lohr, V.; Genzel, Y.; Jordan, I.; Katinger, D.; Mahr, S.; Sandig, V.; Reichl, U.: Live attenuated influenza viruses produced in a suspension process with avian AGE1.CR.pIX cells. BMC Biotechnology 12, p. 79 (2012)
  47. 147.
    Journal Article
    Muth, T.; Garcia-Martin, J. A.; Rausell, A.; Juan, D.; Valencia, A.; Pazos, F.: JDet: interactive calculation and visualization of function-related conservation patterns in multiple sequence alignments and structures. Bioinformatics 28 (4), pp. 584 - 586 (2012)
  48. 148.
    Journal Article
    Platas Barradas, O.; Jandt, U.; Da Minh Phan, L.; Villanueva, M. E.; Schaletzky, M.; Rath, A.; Freund, S.; Reichl, U.; Skerhutt, E.; Scholz, S. et al.; Noll, T.; Sandig, V.; Pörtner, R.; Zeng, A.-P.: Evaluation of criteria for bioreactor comparison and operation standardization for mammalian cell culture. Engineering in Life Sciences 12 (5), pp. 518 - 528 (2012)
  49. 149.
    Journal Article
    Popov, M.; Nacheva, G.; Reichl, U.; Ivanov, I.: Effect of the 3’-terminal truncation of the human interferon-gamma gene on plasmid segregation in escherichia coli. Biotechnology and Biotechnological Equipment 26 (2), pp. 2930 - 2936 (2012)
  50. 150.
    Journal Article
    Rapp, E.; Borowiak, M.: Limonade durch Fermentation. Chemie in unserer Zeit 46 (1), pp. 60 - 61 (2012)
 
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