Publications of Timo Frensing

Kupke, S. Y., Riedel, D., Frensing, T., Zmora, P., & Reichl, U. (2019)A Novel Type of Influenza A Virus-Derived Defective Interfering Particle with Nucleotide Substitutions in Its GenomeJournal of Virology, 93 (4), 01786-18doi: 10.1128/JVI.01786-18.

Laske, T., Bachmann, M., Dostert, M., Karlas, A., Wirth, D., Frensing, T., Meyer, T. F., Hauser, H., & Reichl, U. (2019)Model-based analysis of influenza A virus replication in genetically engineered cell lines elucidates the impact of host cell factors on key kinetic parameters of virus growthPLoS Computational Biology, 15 (4), e1006944doi: 10.1371/journal.pcbi.1006944.

Bachmann, M., Breitwieser, T., Lipps, C., Wirth, D., Jordan, I., Reichl, U., & Frensing, T. (2016)Impaired antiviral response of adenovirus-transformed cell lines supports virus replicationJournal of General Virology, 97 (2), 293–298doi: 10.1099/jgv.0.000361.

Frensing, T., Kupke, S. Y., Bachmann, M., Fritzsche, S., Gallo Ramirez, L. E., & Reichl, U. (2016)Influenza virus intracellular replication dynamics, release kinetics, and particle morphology during propagation in MDCK cellsApplied Microbiology and Biotechnology, 100 (16), 7181–7192doi: 10.1007/s00253-016-7542-4.

Laske, T., Heldt, F. S., Hoffmann, H., Frensing, T., & Reichl, U. (2016)Modeling the intracellular replication of influenza A virus in the presence of defective interfering RNAsVirus Research, 213, 90–99doi: 10.1016/j.virusres.2015.11.016.

Laske, T., Heldt, S., Hoffmann, H., Frensing, T., & Reichl, U. (2016)Reprint of “Modeling the intracellular replication of influenza A virus in the presence of defective interfering RNAsVirus Research, 218, 86–95doi: 10.1016/j.virusres.2016.05.009.

Frensing, T. (2015)Defective interfering viruses and their impact on vaccines and viral vectorsBiotechnology Journal, 10 (5), 681–689doi: 10.1002/biot.201400429.

Heldt, F. S., Kupke, S. Y., Dorl, S., Frensing, T., & Reichl, U. (2015)Single-cell analysis and stochastic modelling unveil large cell-to-cell variability in influenza A virus infectionNature Communications, 6, 8938doi: 10.1038/ncomms9938.

Frensing, T., Pflugmacher, A., Bachmann, M., Peschel, B., & Reichl, U. (2014)Impact of defective interfering particles on virus replication and antiviral host response in cell culture-based influenza vaccine productionApplied Microbiology and Biotechnology, 98 (21), 8999–9008doi: 10.1007/s00253-014-5933-y.

Frensing, T., Heldt, S., Pflugmacher, A., Behrendt, I., Jordan, I., Flockerzi, D., Genzel, Y., & Reichl, U. (2013)Continuous Influenza Virus Production in Cell Culture Shows a Periodic Accumulation of Defective Interfering ParticlesPLoS One, 8 (9), e72288doi: 10.1371/journal.pone.0072288.

Genzel, Y., Frensing, T., & Reichl, U. (2013)Herstellung moderner Grippeimpfstoffe: Zellkultur statt HühnereiChemie in unserer Zeit, 47 (1), 12–22doi: 10.1002/ciuz.201200606.

Heldt, S., Frensing, T., Pflugmacher, A., Gröpler, R., Peschel, B., & Reichl, U. (2013)Multiscale Modeling of Influenza A Virus Infection Supports the Development of Direct-Acting AntiviralsPLoS Computational Biology, 9 (11), e1003372doi: 10.1371/journal.pcbi.1003372.

Heldt, F. S., Frensing, T., & Reichl, U. (2012)Modeling the intracellular dynamics of influenza virus replication to understand the control of viral RNA synthesisJournal of Virology, 86 (15), 7806–7817doi: 10.1128/JVI.00080-12.

Seitz, C., Isken, B., Heynisch, B., Rettkowski, M., Frensing, T., & Reichl, U. (2012)Trypsin promotes efficient influenza vaccine production in MDCK cells by interfering with the antiviral host responseApplied Microbiology and Biotechnology, 93 (2), 601–611doi: 10.1007/s00253-011-3569-8.

Frensing, T., Seitz, C., Heynisch, B., Patzina, C., Kochs, G., & Reichl, U. (2011)Efficient influenza B virus propagation due to deficient interferon-induced antiviral activity in MDCK cellsVaccine, 29 (41), 7125–7129doi: 10.1016/j.vaccine.2011.05.069.

Heynisch, B., Frensing, T., Heinze, K., Seitz, C., Genzel, Y., & Reichl, U. (2010)Differential activation of host cell signaling pathways through infection with two variants of influenza A /Puerto Rico /8/34 (H1N1) in MDCK cellsVaccine, 28 (51), 8210–8218doi: 10.1016/j.vaccine.2010.07.076.

Seitz, C., Frensing, T., Höper, D., Kochs, G., & Reichl, U. (2010)High yields of Influenza A virus in MDCK cells are promoted by an insufficient IFN-induced antiviral stateJournal of General Virology, 91 (7), 1754–1763doi: 10.1099/vir.0.020370-0.

Kupke, S. Y., Riedel, D., Frensing, T., Zmora, P., & Reichl, U. (2018)Single-cell analysis uncovers a novel influenza A virus-derived defective interfering particle for antiviral therapyIn: Vaccine Technology VII, 133.

Laske, T., Bachmann, M., Dostert, M., Karlas, A., Wirth, D., Frensing, T., & Reichl, U.Model-based characterization of influenza A virus production in genetically engineered cell lines elucidates changes in virus replicationPresented at: 3rd Workshop on Virus DynamicsHeidelberg, Germany, October 6, 2017.

Kupke, S. Y., Heldt, S., Frensing, T., & Reichl, U.Single-Cell Analysis of Influenza A Virus-Infected CellsPresented at: 26th Annual Meeting of the Society for VirologyMünster, Germany, July 7, 2016.