Publications BPE group

Carvalho, S. B.; Fortuna, A. R.; Wolff, M. W.; Peixoto, C.; Alves, P. M.; Reichl, U.; Carrondo, M. J. T.: Purification of influenza virus-like particles using sulfated cellulose membrane adsorbers. Journal of Chemical Technology and Biotechnology 93 (7), pp. 1988 - 1996 (2018)

Chuzel, L.; Ganatra, M. B.; Rapp, E.; Henrissat, B.; Taron, C. H.: Functional metagenomics identifies an exosialidase with an inverting catalytic mechanism that defines a new glycoside hydrolase family (GH156). The Journal of Biological Chemistry 293, pp. 18138 - 18150 (2018)

Clerc, F.; Novokmet, M.; Dotz, V.; Reiding, K. R.; de Haan , N.; Kammeijer, G. S.M.; Dalebout, H.; Bladergroen, M. R.; Vukovic, F.; Rapp, E. et al.; Targan, S. R.; Barron, G.; Manetti , N.; Latiano, A.; McGovern, D. P.B.; Annese, V.; Lauc, G.; Wuhrer, M.: Plasma N-Glycan Signatures Are Associated With Features of Inflammatory Bowel Diseases. Gastroenterology 155 (3), pp. 829 - 843 (2018)

Fischer, L. M.; Wolff, M. W.; Reichl, U.: Purification of cell culture-derived influenza A virus via continuous anion exchange chromatography on monoliths. Vaccine 36 (22), pp. 3153 - 3160 (2018)

Fortuna, A. R.; Taft, F.; Villain, L.; Wolff, M. W.; Reichl, U.: Optimization of cell culture-derived influenza A virus particles purification using sulfated cellulose membrane adsorbers. Engineering in Life Sciences 18 (1), pp. 29 - 39 (2018)

Hoffmann, M.; Pioch, M.; Pralow, A.; Hennig, R.; Kottler, R.; Reichl, U.; Rapp, E.: The Fine Art of Destruction: A Guide to In-Depth Glycoproteomic Analyses – Exploiting the Diagnostic Potential of Fragment Ions. Proteomics 18 (24), e1800282 (2018)

Mahour, R.; Klapproth, J.; Rexer, T.; Schildbach, A.; Klamt, S.; Pietzsch, M.; Rapp, E.; Reichl, U.: Establishment of a five-enzyme cell-free cascade for the synthesis of uridine diphosphate N-acetylglucosamine. Journal of Biotechnology 283, pp. 120 - 129 (2018)

Möginger, U.; Grunewald, S.; Hennig, R.; Kuo, C.-W.; Schirmeister, F.; Voth, H.; Rapp, E.; Khoo, K.-H.; Seeberger, P. H.; Simon, J. C. et al.; Kolarich, D.: Alterations of the Human Skin N- and O-Glycome in Basal Cell Carcinoma and Squamous Cell Carcinoma. Frontiers in Oncology 8, 70 (2018)

Muth, T.; Kohrs, F.; Heyer, R.; Benndorf, D.; Rapp, E.; Reichl, U.; Martens, L.; Renard, B. Y.: MPA Portable: A Stand-Alone Software Package for Analyzing Metaproteome Samples on the Go. Analytical Chemistry 90, pp. 685 - 689 (2018)

Nguyen-Khuong, T.; Pralow, A.; Reichl, U.; Rapp, E.: Improvement of electrospray stability in negative ion mode for nano-PGC-LC-MS glycoanalysis via post-column make-up flow. Glycoconjugate Journal 35 (6), pp. 499 - 509 (2018)

Nikolay, A.; Casthilho, L. R.; Reichl, U.; Genzel, Y.: Propagation of Brazilian Zika virus strains in static and suspension cultures using Vero and BHK cells. Vaccine 36 (22), pp. 3140 - 3145 (2018)

Nikolay, A.; Léon, A.; Schwamborn, K.; Genzel, Y.; Reichl, U.: Process intensification of EB66 ^® cell cultivations leads to high-yield yellow fever and Zika virus production. Applied Microbiology and Biotechnology 102 (20), pp. 8725 - 8737 (2018)

Pioch, M.; Hoffmann, M.; Pralow, A.; Reichl, U.; Rapp, E.: GlyXtool^MS: An Open-Source Pipeline for Semiautomated Analysis of Glycopeptide Mass Spectrometry Data. Analytical Chemistry 90 (20), pp. 11908 - 11916 (2018)

Rexer, T.; Schildbach, A.; Klapproth, J.; Schierhorn, A.; Mahour, R.; Pietzsch, M.; Rapp, E.; Reichl, U.: One pot synthesis of GDP-mannose by a multi-enzyme cascade for enzymatic assembly of lipid-linked oligosaccharides. Biotechnology and Bioengineering 115 (1), pp. 192 - 205 (2018)

Rey-Jurado, E.; Tapia, F.; Muñoz-Durango, N.; Lay, M.K.; Carreño, L. J.; Riedel, C. A.; Bueno, S. M.; Genzel, Y.; Kalergis, A. M.: Assessing the Importance of Domestic Vaccine Manufacturing Centers: An Overview of Immunization Programs, Vaccine Manufacture, and Distribution. Frontiers in Immunology 9, 26 (2018)

Vazquez-Ramirez, D.; Genzel, Y.; Jordan, I.; Sandig, V.; Reichl, U.: High-cell-density cultivations to increase MVA virus production. Vaccine 36 (22), pp. 3124 - 3133 (2018)

Vodovnik, M.; Vrabec, K.; Hellwig, P.; Benndorf, D.; Sezun, M.; Gregori, A.; Gottumukkala, L. D.; Anderson, R. C.; Reichl, U.: Valorisation of deinking sludge as a substrate for lignocellulolytic enzymes production by Pleurotus ostreatus. Journal of Cleaner Production 197 (Part 1), pp. 253 - 263 (2018)

Wasik, M.; Eichwald, L.; Genzel, Y.; Reichl, U.: Cell culture-based production of defective interfering particles for influenza antiviral therapy. Applied Microbiology and Biotechnology 102 (3), pp. 1167 - 1177 (2018)

Wenzel, L.; Heyer, R.; Schallert, K.; Löser, L.; Wünschiers, R.; Reichl, U.; Benndorf, D.: SDS-PAGE fractionation to increase metaproteomic insight into the taxonomic and functional composition of microbial communities for biogas plant samples. Engineering in Life Sciences 18 (7), pp. 498 - 509 (2018)

Duvigneau, S.; Dürr, R.; Laske, T.; Bachmann, M.; Dostert, M.; Reichl, U.; Kienle, A.: Mathematical modeling as a tool to improve influenza vaccine production processes. FOSBE 2018, Chicago, Illinois, USA, August 05, 2018 - August 08, 2018. IFAC-PapersOnLine 51 (19), pp. 1 - 4 (2018)

Rüdiger, D.; Kupke, S. Y.; Reichl, U.: A multiscale model of influenza A virus replication covering highly different infection conditions in cell cultures. IFAC-PapersOnLine 51 (19), pp. 32 - 33 (2018)

Zoun, R.; Campero Durand, G.; Schallert , K.; Patrikar, A.; Broneske, D.; Fenske, W.; Heyer, R.; Benndorf, D.; Saake, G.: Protein Identification as a Suitable Application for Fast Data Architecture. DEXA : International Conference on Database and Expert Systems Applications , Regensburg, Germany, September 03, 2018 - September 06, 2018. Database and Expert Systems Applications: DEXA 2018 International Workshops BDMICS, BIOKDD, and TIR 903, pp. 168 - 178 (2018)

Bissinger, T.; Reichl, U.; Genzel, Y.; Wu, Y.; Liu, X.; Tan, W.-S.: Highly efficient influenza virus production: A MDCK-based high-cell-density process. In Vaccine Technology VII, 13. Vaccine Technology VII, Mont Tremblant, Canada, June 17, 2018 - June 22, 2018. (2018)

Coronel, J.; Genzel, Y.; Reichl, U.; Behrendt, I.; Buergin, T.; Andereli, T.; Sandig, V.: Orbital shaken bioreactor for influenza A virus production in high cell density cultivations. In Vaccine Technology VII, 40. Vaccine Technology VII, Mont Tremblant, Canada, June 17, 2018 - June 22, 2018. (2018)

Fortuna, A. R.; Taft, F.; Villain, L.; Wolff, M. W.; Reichl, U.: Continuous purification of cell culture-derived influenza A virus particles through pseudo- affinity membrane chromatography. In Vaccine Technology VII, 124. Vaccine Technology VII, Mont Tremblant, Canada, June 17, 2018 - June 22, 2018. (2018)

Gränicher, G.; Genzel, Y.; Reichl, U.; John, K.; Sandig, V.; Karlas, A.: A new porcine suspension cell line (PBG.PK-21) provides efficient production for influenza and yellow fever vaccine viruses. In Vaccine Technology VII, 48. Vaccine Technology VII, Mont Tremblant, Canada, June 17, 2018 - June 22, 2018. (2018)

Kupke, S. Y.; Riedel, D.; Frensing, T.; Zmora, P.; Reichl, U.: Single-cell analysis uncovers a novel influenza A virus-derived defective interfering particle for antiviral therapy. In Vaccine Technology VII, 133. Vaccine Technology VII, Mont Tremblant, Canada, June 17, 2018 - June 22, 2018. (2018)

Marichal-Gallardo, P.; Fortuna, A. R.; Genzel, Y.; Wolff, M. W.; Reichl, U.: Purifying viruses with a sheet of paper: Single-use steric exclusion chromatography as a capture platform for vaccine candidates. In Vaccine Technology VII, 128. Vaccine Technology VII, Mont Tremblant, Canada, June 17, 2018 - June 22, 2018. (2018)

Nikolay, A.; Genzel, Y.; Schwamborn, K.; Leon, A.; Reichl, U.: Flavivirus production in perfusion processes using the EB66® cell line. In Vaccine Technology VII, 80. Vaccine Technology VII, Mont Tremblant, Canada, June 17, 2018 - June 22, 2018. (2018)

Peixoto, C.; Carvalho, S. B.; Carrondo, M. J.T.; Alves , P. M.; Fortuna, A. R.; Reichl, U.; Wolff, M. W.: Addressing the challenges of influenza virus-like particles purification. In Vaccine Technology VII, 57. Vaccine Technology VII, Mont Tremblant, Canada, June 17, 2018 - June 22, 2018. (2018)

Rossdamm, C.; Konze, S. A.; Oberbeck, A.; Rapp, E.; Gerardy-Schahn, R.; von Itzstein, M.; Buettner, F. F. R.: CGE-LIF as a novel approach for the analysis of glycosphingolipid-derived glycans. In GLYCOBIOLOGY, 28 12 Ed., 144, pp. 1057 - 1058. Annual Meeting of the Society-for-Glycobiology (SFG), New Orleans, LA (USA), November 05, 2018 - November 08, 2018. (2018)

Taft, F.; Köhler, R.; Van Teeffelen, S.; Fortuna, A. R.; Wolff, M. W.; Reichl, U.; Villain, L.; Boulais, A.: Influenza virus capture using membrane chromatography: Improving selectivity by matrix design and pseudo-affinity ligand interactions. In Vaccine Technology VII, 75. Vaccine Technology VII, Mont Tremblant, Canada, June 17, 2018 - June 22, 2018. (2018)

Wu, Y.; Liu, X.; Tan, W.-S.; Bissinger, T.; Genzel, Y.; Reichl, U.: Efficient influenza vaccine manufacturing: Single MDCK suspension cells in chemically defined medium. In Vaccine Technology VII, 5. Vaccine Technology VII, Mont Tremblant, Canada, June 17, 2018 - June 22, 2018. (2018)

Benndorf, D.: Speedup of metaproteomics pipelines - from samples to microbial community data in less than 24 hours. 3rd International Metaproteome Symposium, Leipzig, Germany (2018)

Duvigneau, S.; Dürr, R.; Laske, T.; Bachmann, M.; Dostert, M.; Reichl, U.; Kienle, A.: Mathematical modeling as a tool to improve influenza vaccine production processes. FOSBE 2018, Chicago, Illinois, USA (2018)

Genzel, Y.: Perfusion with shaken bioreactors. Meeting on orbital shaken bioreactors (from µL up to 2500 L), Mas Boada, Spain (2018)

Genzel, Y.: Intensified cell-based viral vaccine processes: from continuous to perfusion to hybrid systems. BioProNet Meeting, London, UK (2018)

Genzel, Y.: ESACT Vaccine Course: Upstream Process Development: From Master Seed to Production. ESACT Vaccine Course: Upstream Process Development - From Master Seed to Production 2018, Llafranc, Spain (2018)

Genzel, Y.: ESACT Vaccine Course: Upstream Process Intensification. ESACT Course 2018, Llafranc, Spain (2018)

Genzel, Y.: ESACT Vaccine Course: Introduction to Cell Culture-produced Viral Vaccines. ESACT Course 2018, Llafranc, Spain (2018)

Hoffmann, M.: Towards Understanding of Congenital Disorders of Glycosylation: A Glyco(proteo)mic Approach to Unravel the Interplay between Different Types of Glycosylation. DFG FOR 2509 Meeting , Höchst (Odenwald), Germany (2018)

Kozlowski, A.; Pischel, D.; Fachet, M.; Pirwitz, K.; Flassig, R.; Sundmacher, K.: From Lab to Outdoor: Modeling Light Fluctuations in Algal Photobioreactors to Identify Economically Feasible Solutions. Young Algaeneers Symposium, Oban, UK (2018)

Kupke, S. Y.: Single-Cell analysis uncover a novel influenza A virus-derived defective interfering particle for antiviral therapy. Vaccine Technology VII, Mont Tremblant, Canada (2018)

Marichal-Gallardo, P.; Genzel, Y.; Börner, K.; Grimm, D.; Wolff, M. W.; Reichl, U.: A single-use purification platform for viral vaccines & gene therapy vectors. International Symposium on the Separation of Proteins, Peptides, and Polynucleotides (ISPPP) 2018, Berlin, Germany (2018)

Marichal-Gallardo, P.; Lothert, K.; Grein, T.; Reichl, U.; Czermak, P.; Wolff, M. W.: Single-use purification of cell culture-based virus particles by steric exclusion chromatography. National Meeting of the American Chemical Society (ACS), New Orleans, USA (2018)

Nikolay, A.: Stable animal cell growth in perfusion processes: Using on-line permittivity sensors to control cell-specific perfusion rates. 5th BioProScale Symposium, Berlin, Germany (2018)

Nikolay, A.: Cell-culture-based perfusion processes for Flavivirus production. 5th Laupheim Biotech Days, Laupheim, Germany (2018)

Benndorf, D.; Heyer, R.; Schallert, K.; Püttker, S.; Kohrs, F.; Theuerl, S.; Schlüter, A.; Reichl, U.: Metaproteomics of biogas plants reveals that biogas producing microbial communities are shaped by syntrophy, competition and phage-host interactions. International Society for Microbial Ecology Conference (ISME), Leipzig Germany (2018)

Bissinger, T.; Rodrigues Correia Ramos, J.; Ringeisen, J.; Genzel, Y.; Reichl, U.: Dynamics of intracellular metabolite pools in MDCK suspension cells during cell growth and influenza virus infection. Cell Culture Engineering XVI, Tampa, Florida, USA (2018)

Bissinger, T.; Wu, Y.; Genzel, Y.; Liu, X.; Wen-Song, T.; Reichl, U.: Efficient influenza virus production: a MDCK-based high-cell-density process. Vaccine Technology VII, Mont Tremblant, Canada (2018)