Publications BPE group

Carrondo, M. J. T.; Alves, P. M.; Carinhas, N.; Glassey, J.; Hesse, F.; Merten, O.-W.; Micheletti, M.; Noll, T.; Oliveira, R.; Reichl, U. et al.; Staby, A.; Teixeira, A. P.; Weichert, H.; Mandenius, C.-F.: How can measurement, monitoring, modeling and control advance cell culture in industrial biotechnology? Biotechnology Journal 7 (12), pp. 1522 - 1529 (2012)

Hanreich, A.; Heyer, R.; Benndorf, D.; Rapp, E.; Pioch, M.; Reichl, U.; Klocke, M.: Metaproteome analysis to determine the metabolically active part of thermophilic microbial community producing biogas from agricultural biomass. Canadian Journal of Microbiology 58 (7), pp. 917 - 922 (2012)

Heldt, F. S.; Frensing, T.; Reichl, U.: Modeling the intracellular dynamics of influenza virus replication to understand the control of viral RNA synthesis. Journal of Virology 86 (15), pp. 7806 - 7817 (2012)

Isken, B.; Genzel, Y.; Reichl, U.: Productivity, apoptosis, and infection dynamics of influenza A/PR/8 strains and A/PR/8-based reassortants. Vaccine 30 (35), pp. 5253 - 5261 (2012)

Kluge, S.; Hoffmann, M.; Benndorf, D.; Rapp, E.; Reichl, U.: Proteomic tracking and analysis of a bacterial mixed culture. Proteomics 12 (12), pp. 1893 - 1901 (2012)

Kolmakov, K.; Wurm, C.; Hennig, R.; Rapp, E.; Jakobs, S.; Belov, V. N.; Hell, S. W.: Red-Emitting Rhodamines with Hydroxylated, Sulfonated, and Phosphorylated Dye Residues and Their Use in Fluorescence Nanoscopy. Chemistry - A European Journal 18 (41), pp. 12986 - 12998 (2012)

Lohr, V.; Genzel, Y.; Jordan, I.; Katinger, D.; Mahr, S.; Sandig, V.; Reichl, U.: Live attenuated influenza viruses produced in a suspension process with avian AGE1.CR.pIX cells. BMC Biotechnology 12, p. 79 (2012)

Muth, T.; Garcia-Martin, J. A.; Rausell, A.; Juan, D.; Valencia, A.; Pazos, F.: JDet: interactive calculation and visualization of function-related conservation patterns in multiple sequence alignments and structures. Bioinformatics 28 (4), pp. 584 - 586 (2012)

Platas Barradas, O.; Jandt, U.; Da Minh Phan, L.; Villanueva, M. E.; Schaletzky, M.; Rath, A.; Freund, S.; Reichl, U.; Skerhutt, E.; Scholz, S. et al.; Noll, T.; Sandig, V.; Pörtner, R.; Zeng, A.-P.: Evaluation of criteria for bioreactor comparison and operation standardization for mammalian cell culture. Engineering in Life Sciences 12 (5), pp. 518 - 528 (2012)

Popov, M.; Nacheva, G.; Reichl, U.; Ivanov, I.: Effect of the 3’-terminal truncation of the human interferon-gamma gene on plasmid segregation in escherichia coli. Biotechnology and Biotechnological Equipment 26 (2), pp. 2930 - 2936 (2012)

Rapp, E.; Borowiak, M.: Limonade durch Fermentation. Chemie in unserer Zeit 46 (1), pp. 60 - 61 (2012)

Riedele, C.; Reichl, U.: Time-kill studies with a ceftazidime-treated mixed culture consisting of Pseudomonas aeruginosa, Burkholderia cepacia and Staphylococcus aureus. Engineering in Life Sciences 12 (2), pp. 188 - 197 (2012)

Rüger, M.; Bensch, G.; Tüngler, R.; Reichl, U.: A Flow Cytometric Method for Viability Assessment of Staphylococcus aureus and Burkholderia cepacia in Mixed Culture. Cytometry Part A 81 A (12), pp. 1055 - 1066 (2012)

Seitz, C.; Isken, B.; Heynisch, B.; Rettkowski, M.; Frensing, T.; Reichl, U.: Trypsin promotes efficient influenza vaccine production in MDCK cells by interfering with the antiviral host response. Applied Microbiology and Biotechnology 93 (2), pp. 601 - 611 (2012)

Selman, M. H. J.; Hoffmann, M.; Zauner, G.; McDonnell, L. A.; Balog, C. I. A.; Rapp, E.; Deelder, A. M.; Wuhrer, M.: MALDI-TOF-MS analysis of sialylated glycans and glycopeptides using 4-chloro-α-cyanocinnamic acid matrix. Proteomics 12 (9), pp. 1337 - 1348 (2012)

Zauner, G.; Hoffmann, M.; Rapp, E.; Koeleman, C. A. M.; Dragan, I.; Deelder, A. M.; Wuhrer, M.; Hensbergen, P. J.: Glycoproteomic Analysis of Human Fibrinogen Reveals Novel Regions of O‑Glycosylation. Journal of Proteome Research 11 (12), pp. 5804 - 5814 (2012)

Dürr, R.; Müller, T.; Isken, B.; Schulze-Horsel, J.; Reichl, U.; Kienle, A.: Distributed Modeling and Parameter Estimation of Influenza Virus Replication During Vaccine Production. MATHMOD 2012 - 7th Vienna International Conference on Mathematical Modelling, Vienna, Austria, February 15, 2012 - February 17, 2012. IFAC Proceedings Volumes 45 (2), pp. 320 - 325 (2012)

Isken, B.; Schulze-Horsel, J.; Bock, A.; Genzel, G.; Reichl, U.: Monitoring of Host-Cell Infection and Virus-Induced Apoptosis in Influenza Vaccine Production. In: ESACT - Proceedings of the 21st Annual meeting of the European Society for animal cell technology (ESACT), pp. 675 - 683 (Eds. Jenkins, N.; Barron, N.; Alves, P.). 21st ESACT Meeting , Dublin, Ireland, June 07, 2009 - June 10, 2009. (2012)

Kröber, T.; Wolff, M. W.; Lehmann, S.; Zimmermann, A.; Reichl, U.: Accounting for the Entire Influenza Hemagglutinin during a Flu Vaccine Production Process. In: ESACT - Proceedings of the 21st Annual meeting of the European Society for animal cell technology (ESACT), pp. 685 - 689. 21st ESACT Meeting , Dublin, Ireland, June 07, 2009 - June 10, 2009. Berlin (2012)

Lohr, V.; Rath, A.; Jordan, I.; Sandig, V.; Genzel, Y.; Reichl, U.: Avian Designer Cells AGE1.CR as Candidates for MVA and Influenza Vaccine Production. In: ESACT - Proceedings of the 21st Annual meeting of the European Society for animal cell technology (ESACT), pp. 615 - 631 (Eds. Jenkins, N.; Barron, N.; Alves, P.). 21st ESACT Meeting, Dublin, Ireland, June 07, 2009 - June 10, 2009. (2012)

Öncül, A. A.; Genzel, Y.; Reichl, U.; Thévenin, D.: Flow characterization in wave bioreactors using Computational Fluid Dynamics. In: ESACT - Proceedings of the 21st Annual meeting of the European Society for animal cell technology (ESACT), pp. 455 - 469 (Eds. Jenkins, N.; Barron, N.; Alves, P.). 21st ESACT Meeting, Dublin, Ireland, June 07, 2009 - June 10, 2009. Dordrecht (2012)

Roedig, J.; Rapp, E.; Hennig, R.; Schwarzer, J.; Reichl, U.: Optimized CGE-LIF-based glycan analysis for high-throughput applications. In: ESACT - Proceedings of the 21st Annual meeting of the European Society for animal cell technology (ESACT), pp. 599 - 603 (Eds. Jenkins, N.; Barron, N.; Alves, P.). 21st ESACT Meeting, Dublin, Ireland, June 07, 2009 - June 10, 2009. (2012)

Schenkendorf, R.; Mangold, M.; Reichl, U.: Parameter Identification of Time-Delay Systems: A Flatness Based Approach. MATHMOD 2012 - 7th Vienna International Conference on Mathematical Modelling, Vienna, Austria, February 15, 2012 - February 17, 2012. IFAC Proceedings Volumes 45 (2), pp. 165 - 170 (2012)

Dürr, R.; Müller, T.; Isken, B.; Schulze-Horsel, J.; Reichl, U.; Kienle, A.: Distributed Modeling and Parameter Estimation of Influenza Virus Replication During Vaccine Production. MATHMOD 2012 - 7th Vienna International Conference on Mathematical Modelling, Vienna, Austria (2012)

Genzel, Y.; Lohr, V.; Behrendt, I.; Scharfenberg, K.; Kamen, A.; Schiedner, G.; Jordan, I.; Reichl, U.: Cell culture-based influenza virus production: suspension or adherent producer cell lines? Cell line development and engineering 2012, Cologne, Germany (2012)

Genzel, Y.; Vogel, T.; Buck, J.; Behrendt, I.; Schiedner, G.; Jordan, I.; Reichl, U.: High cell density cultivations for influenza virus production using suspension cells. Vaccine Technology IV, Albufeira, Portugal (2012)

Heldt, F. S.; Frensing, T.; Reichl, U.: Elucidating bottlenecks in influenza virus replication to optimize vaccine production. International Conference on the Systems Biology of Human Disease, Heidelberg, Germany (2012)

Hennig, R.; Borowiak, M.; Reichl, U.; Rapp, E.; Kottler, R.: Tailored sample preparation methods for xCGE-LIF based carbohydrate analysis. 23rd Joint Glycobiology Meeting 2012, Wageningen, The Netherlands (2012)

Janke, R.; Genzel, Y.; Reichl, U.: A high-throughput assay to assess enzyme activity in central metabolism of production cell lines. Cell Culture Engineering XIII, Scottsdale, Arizona, USA (2012)

Jarosch, T.: Screening for hydrophobic interaction chromatography conditions for downstreaming of influenza virus. ACHEMA 2012, Frankfurt am Main, Germany (2012)

Kluge, S.; Rourou, S.; Genzel, Y.; Benndorf, D.; Majoul, S.; Rapp, E.; Kallel, H.; Reichl, U.: Proteomanalyse der Virus-Wirtszell-Interaktion: Tollwutvirus-Replikation in einer Vero Zelllinie unter Einfluss zweier Zellkulturmedien. Biopharmazeutische Produktion 2012, Freiburg (2012)

Lagoda, A.: Dynamics of influenza A virsu transcription & replication in mammalian cell culture. 22nd Annual Meeting of the Society for Virology, Essen, Germany (2012)

Rath, A.; Scholz, S.; Noll, T.; Janke, R.; Genzel, Y.; Rose, T.; Sandig, V.; Reichl, U.: Insights into mammalian energy metabolism: connecting intracellular metabolites and maximum enzyme activities. GVC/DECHEMA Vortrags- und Diskussionstagung - Biopharmazeutische Produktion, Freiburg (2012)

Reichl, U.: Cell Culture-derived Influenza Vaccine Production. Sächsische Akademie der Wisenschaften: Sitzung der Technikwissenschaftlichen Klasse, Leipzig (2012)

Rödig, J.; Rapp, E.; Hütter, J.; Lepenies, B.; Bohne, J.; Genzel, Y.; Höper, D.; Reichl, U.: Process Conditions can markedly affect the N-glycosylation pattern and immunogenicity of influenza A virus. ACTIP Meeting, Marburg (2012)

Rödig, J.; Rapp, E.; Hütter, J.; Lepenies, B.; Schwarzer, J.; Genzel, Y.; Höper, D.; Reichl, U.: Impact of process conditions on influenza A virus HA N-glycosylation and immunogenicity. ProcessNet-Jahrestagung und 30. DECHEMA-Jahrestagung der Biotechnologen, Karlsruhe (2012)

Rüger, M.; Reichl, U.: Charakterisierung medizinisch-relevanter bakterieller Mischkulturen mittels t-RFLP und Durchflusszytometrie. ProcessNet Jahrestagung 2012 und 30. Jahrestagung der Biotechnologen, Karlsruhe, Germany (2012)

Rüger, M.; Weinholz, S.; Wassermann, M.; Cordes, C.; Reichl, U.: Viability analysis of Lactobacillus plantarum by flow cytometry. ACHEMA 2012 Congress, Frankfurt, Germany (2012)

Wolff, M.; Reichl, U.: Downstream Processing of Cell Culture-derived Virus Particles. ProcessNet-Membranverfahren in der Biotechnologie, Frankfurt am Main, Germany (2012)

Frensing, T.; Heldt, S.; Reichl, U.: Modeling influenza virus replication on a single cell level. 3rd International Influenza Meeting, Muenster, Germany (2012)

Freund, S.; Rath, A.; Rose, T.; Sandig, V.; Reichl, U.: Metabolic Flux Analysis of AAT Production in AGE1.HN.AAT Cells under Different Cultivation Conditions. ESBES - 9 th European Symposium on Biochemical Engineering Science, Istanbul (2012)

Freund, S.; Rath, A.; Sandig, V.; Rose, T.; Reichl, U.: Comparison of the productivity of a new human cell line in different steady states of continuous cultivations using MFA. Metabolic Engineering IX, Biarritz, France (2012)

Heldt, F. S.; Frensing, T.; Reichl, U.: Elucidating bottlenecks in influenza virus replication to optimize vaccine production. International Conference on the Systems Biology of Human Disease, Heidelberg, Germany (2012)

Heldt, F. S.; Frensing, T.; Reichl, U.: Elucidating the dynamics of influenza virus replication by mathematical modeling. 22nd Annual Meeting of the Society for Virology, Essen, Germany (2012)

Hennig, R.; Borowiak, M.; Kottler, R.; Reichl, U.; Rapp, E.: Tailored sample preparation methods for xCGE-LIF based carbohydrate analysis. 23rd Joint Glycobiology Meeting 2012, Wageningen, The Netherlands (2012)

Hennig, R.; Muth, T.; Reichl, U.; Rapp, E.: glyXtool – a software for automated high-throughput processing of xCGE-LIF based glycoanalysis data. 6th Glycan Forum, Berlin, Germany (2012)

Hütter, J.; Rödig, J.; Höper, D.; Reichl, U.; Seeberger, P. H.; Rapp, E.; Lepenies, B.: Glycosylation matters: role of viral hemagglutinin N-glycosylation in immunogenicity. European Congress of Immunology, Glasgow, Scotland (2012)

Kottler, R.; Hennig, R.; Mank, M.; Stahl, B.; Reichl, U.; Rapp, E.: In-Depth Characterization of the Human Milk Oligosaccharide Composition via xCGE-LIF, Utilizing a Multiplexing Capillary DNA Sequencer. 6th Glycan Forum, Berlin, Germany (2012)

Lohr, V.; Blechert, A.-K.; Genzel, Y.; Jordan, I.; Reichl, U.: Characterization of AGE1.CR.pIX high cell density cultivations for vaccinia virus production. GVC/DECHEMA Vortrags- und Diskussionstagung Biopharmazeutische Produktion, Freiburg, Germany (2012)

Lohr, V.; Genzel, Y.; Katinger, D.; Jordan, I.; Sandig, V.; Reichl, U.: Live attenuated influenza virus production in batch high cell density cultivation of suspension AGE1.CR.pIX cells. Vaccine Technology IV, Albufeira, Portugal (2012)