Publications BPE group

Arigoni-Affolter, I.; Losfeld, M.-E.; Hennig, R.; Rapp, E.; Aebi, M.: A hierarchical structure in the N-glycosylation process governs the N-glycosylation output: prolonged cultivation induces glycoenzymes expression variations that are reflected in the cellular N-glycome but not in the protein and site-specific glycoprofile of CHO cells. Glycobiology 34 (8), cwae045 (2024)

Böttinger, K.; Regl, C.; Schäpertöns, V.; Rapp, E.; Wohlschlager, T.; Huber, C. G.: “Small is beautiful” – examining reliable determination of low- abundant therapeutic antibody glycovariants. Journal of Pharmaceutical Analysis 14 (10), 100982 (2024)

Göbel, S.; Kazemi, O.; Ma, J.; Jordan, I.; Sandig, V.; Paulissen, J.; Kerstens, W.; Thibaut, H. J.; Reichl, U.; Dallmeier, K. et al.; Genzel, Y.: Parallel Multifactorial Process Optimization and Intensification for High-Yield Production of Live YF17D-Vectored Zika Vaccine. Vaccines 12 (7), 755 (2024)

Göbel, S.; Pelz, L.; Silva, C. A. T.; Brühlmann, B.; Hill, C.; Altomonte, J.; Kamen, A.; Reichl, U.; Genzel, Y.: Production of recombinant vesicular stomatitis virus-based vectors by tangential flow depth filtration. Applied Microbiology and Biotechnology 108 (1), 240 (2024)

Guzman Ruiz, L.; Zollner, A. M.; Hoxie, I.; Küchler, J.; Hausjell, C.; Mesurado, T.; Krammer, F.; Jungbauer, A.; Pereira Aguilar, P.; Klausberger, M. et al.; Grabherr, R.: Enhancing NA immunogenicity through novel VLP designs. Vaccine 42 (24), 126270 (2024)

Hellwig, P.; Dittrich, A.; Heyer, R.; Reichl, U.; Benndorf, D.: Detection, isolation and characterization of phage-host complexes using BONCAT and click chemistry. Frontiers in Microbiology 15, 1434301 (2024)

Hellwig, P.; Kautzner, D.; Heyer, R.; Dittrich, A.; Wibberg, D.; Busche, T.; Winkler, A.; Reichl, U.; Benndorf, D.: Tracing active members in microbial communities by BONCAT and click chemistry-based enrichment of newly synthesized proteins. ISME Communications 4 (1), ycae153 (2024)

Heyer, R.; Hellwig, P.; Maus, I.; Walke, D.; Schlüter, A.; Hassa, J.; Sczyrba, A.; Tubbesing, T.; Klocke, M.; Mächtig, T. et al.; Schallert, K.; Seick, I.; Reichl, U.; Benndorf, D.: Breakdown of hardly degradable carbohydrates (lignocellulose) in a two-stage anaerobic digestion plant is favored in the main fermenter. Water Research 250, 121020 (2024)

Huber, N.; Alcalá Orozco, E. A.; Rexer, T.; Reichl, U.; Klamt, S.: Model-based optimization of cell-free enzyme cascades exemplified for the production of GDP-fucose. Metabolic Engineering 81, pp. 10 - 25 (2024)

Karsten, C. B.; Buettner, F. F. R.; Cajic, S.; Nehlmeier, I.; Roshani, B.; Klippert, A.; Sauermann, U.; Stolte-Leeb, N.; Reichl, U.; Gerardy-Schahn, R. et al.; Rapp, E.; Stahl-Hennig, C.; Pöhlmann, S.: Macrophage- and CD4+ T cell-derived SIV differ in glycosylation, infectivity and neutralization sensitivity. PLOS Pathogens 20 (5), e1012190 (2024)

Khesali Aghtaei, H.; Heyer, R.; Reichl, U.; Benndorf, D.: Improved biological methanation using tubular foam-bed reactor. Biotechnology for Biofuels and Bioproducts 17, 66 (2024)

Offersgaard, A.; Duarte Hernandez, C. R.; Zhou, Y.; Duan, Z.; Gammeltoft, K. A.; Hartmann, K. T.; Fahnøe, U.; Marichal-Gallardo, P.; Alzua, G. P.; Underwood, A. P. et al.; Sølund, C.; Weis, N.; Bonde, J. H.; Christensen, J. P.; Pedersen, G. K.; Jensen, H. E.; Holmbeck, K.; Bukh, J.; Gottwein, J. M.: An inactivated SARS-CoV-2 vaccine based on a Vero cell culture-adapted high-titer virus confers cross-protection in small animals. Scientific Reports 14 (1), 17039 (2024)

Pelz, L.; Dogra, T.; Marichal-Gallardo, P.; Hein, M. D.; Hemissi, G.; Kupke, S. Y.; Genzel, Y.; Reichl, U.: Production of antiviral “OP7 chimera” defective interfering particles free of infectious virus. Applied Microbiology and Biotechnology 108, 97 (2024)

Riedel, R.; Commichau, F. M.; Benndorf, D.; Hertel, R.; Holzer, K.; Hoelzle, L. E.; Mardoukhi, M. S. Y.; Noack, L. E.; Martienssen, M.: Biodegradation of selected aminophosphonates by the bacterial isolate Ochrobactrum sp. BTU1. Microbiological Research 280, 127600 (2024)

Riedel, R.; Meißner, K.; Kaschubowski, A.; Benndorf, D.; Martienssen, M.; Braun, B.: Laundry Isolate Delftia sp. UBM14 Capable of Biodegrading Industrially Relevant Aminophosphonates. Microorganisms 12 (8), 1664 (2024)

Rüdiger, D.; Piasecka, J.; Küchler, J.; Pontes, C.; Laske, T.; Kupke, S. Y.; Reichl, U.: Mathematical model calibrated to in vitro data predicts mechanisms of antiviral action of the influenza defective interfering particle “OP7”. iScience 27 (4), 109421 (2024)

Zinnecker, T. M.; Badri, N.; Araujo, D.; Thiele, K.; Reichl, U.; Genzel, Y.: From single‐cell cloning to high‐yield influenza virus production – implementing advanced technologies in vaccine process development. Engineering in Life Sciences 24 (4), 2300245 (2024)

Zinnecker, T. M.; Reichl, U.; Genzel, Y.: Innovations in cell culture-based influenza vaccine manufacturing – from static cultures to high cell density cultivations. Human Vaccines & Immunotherapeutics 20 (1), 2373521 (2024)

Heyer, R.; Schallert, K.; Briza, M.; Benndorf, D.: Metaproteomic Analysis of Biogas Plants: A Complete Workflow from Lab to Bioinformatics. In: Metaproteomics: Methods in Molecular Biology, pp. 99 - 113 (Ed. Salerno, C.). Humana Press, New York, NY (2024)

Alcalá Orozco, E. A.; Huber, N.; Klamt, S.; Rexer, T.; Reichl, U.: A cell-free enzymatic cascade for the synthesis of GDP-fucose - modeling and optimization. 6^th MECP (Multistep Enzyme Catalyzed Processes) Congress, Vienna (Austria) (2024)

Genzel, Y.; Göbel, S.; Reichl, U.: Shaking to very high cell densities - perfusion for virus production. Kuhner Large Scale Meeting, Girona (Spain) (2024)

Genzel, Y.; Zinnecker, T. M.; Göbel, S.; Reichl, U.: Next-generation virus production: from clone, to AMBR, to perfusion and very high virus yield. 8th Edition of the "International Symposium on Immunobiologicals" (8th ISI), Rio de Janeiro (Brazil) (2024)

Nguyen, R. T.: eversyn - Making high-value glycans mainstream. Sustainable Future Selection Day, Sunnyvale (USA) (2024)

Nguyen, R. T.: eversyn - Making high-value glycans mainstream. Sustainable Future Selection Day, San Francisco (USA) (2024)

Pelz, L.; Rüdiger, D.; Hein, M.; Böhme, J.; Bälkner, M.; Kershaw, O.; Marichal-Gallardo, P.; Gruber, A.; Genzel, Y.; Bruder, D. et al.; Kupke, S. Y.; Reichl, U.: Engineered defective interfering particles of influenza A virus for antiviral treatment. 33^rd Annual Meeting of the Society for Virology (GfV), Vienna (Austria) (2024)

Pelz, L.; Rüdiger, D.; Hein, M. D.; Böhme, J.; Bälkner, M.; Kershaw, O.; Marichal-Gallardo, P.; Gruber, A.; Genzel, Y.; Bruder, D. et al.; Kupke, S. Y.; Reichl, U.: Genetic engineering of Influenza A virus defective interfering particles towards improved antiviral efficacy and potential use as a live vaccine. Vaccine Technology IX, Los Cabos (Mexico) (2024)

Rexer, T.: Plattform for the in-vitro glycoengineering of proteins. 17th Annual European Life Sciences CEO Forum, Zurich (Switzerland) (2024)

Rüdiger, D.; Opitz, P.; Kupke, S. Y.; Reichl, U.: A two-dimensional model to predict influenza virus and defective interfering particle coinfection in tissue-like systems. 28th ESACT Meeting, Edingburgh (Scotland) (2024)

Rüdiger, D.; Opitz, P.; Kupke, S. Y.; Reichl, U.: Predicting the antiviral efficacy of defective interfering particles against influenza virus infection in tissues. KSMB-SMB 2024, Seoul (South Korea) (2024)

Zinnecker, T. M.; Thiele, K.; Schmidberger, T.; Reichl, U.; Genzel, Y.: Influenza A Virus Production following Quality by Design Principles. Vaccine Technology IX, Los Cabos (Mexico) (2024)

Zuniga-Banuelos, F. J.; Lemke, G.; Hoffmann, M.; Reichl, U.; Rapp, E.: Discovering Rare Sialylated N glycans Holding O Acetylation or Sulfation within the Site-Specific N glycosylation of Human Serum IgA. SialoGlyco 2024 (International Conference in SialoGlycobiology 2024), Lille (France) (2024)

Zuniga-Banuelos, F. J.; Lemke, G.; Hoffmann, M.; Reichl, U.; Rapp, E.: Including N glycopeptides Bearing Glucuronidated, O Acetylated or Sulfated N glycans in the Analysis of Human Serum Proteins such as Immunoglobulin A. 33rd Joint Glycobiology Meeting (JGM) , Hannover (Germany) (2024)

Zuniga-Banuelos, F. J.; Lemke, G.; Hoffmann, M.; Reichl, U.; Rapp, E.: Expanding Glycoproteomics: Including N‑glycopeptides Bearing Glucuronidated, O‑Acetylated or Sulfated N‑glycans in the Analysis of Human Serum Proteins such as Immunoglobulin A. EGC 2024 webinar (European Glycoscience Community Webinar Series), online (2024)

Dogra, T.; Pelz, L.; Rüdiger, D.; Hein, M. D.; Böhme, J.; Bälkner, M.; Kershaw, O.; Marichal-Gallardo, P.; Gruber, A.; Genzel, Y. et al.; Bruder, D.; Kupke, S. Y.; Reichl, U.: Genetically engineered defective interfering particles for antiviral treatment and vaccination. 28th ESACT Meeting, Edingburgh (Scotland) (2024)

Jacobtorweihe, L.; Göbel, S.; Wolschek, M.; Altomonte, J.; Reichl, U.; Genzel, Y.: HCD Perfusion of CCX.E10 Quail Cells for Production of Vesicular Stomatitis Virus based oncolytic Vaccine. Vaccine Technology IX, Los Cabos (Mexico) (2024)

Jacobtorweihe, L.; Göbel, S.; Wolschek, M.; Altomonte, J.; Reichl, U.; Genzel, Y.: Production of Oncolytic rVSV-NDV in CCX.E10 Quail Cells by HCD Perfusion Culture. Himmelfahrtstagung on Bioprocess Engineering 2024, Regensburg (Germany) (2024)

Jacobtorweihe, L.; Madeline, B.; Léon, A.; Genzel, Y.; Reichl, U.: Production of Oncolytic Newcastle Disease Virus in EB66 cells. 28th ESACT Meeting, Edingburgh (Scotland) (2024)

Küchler, J.; Opitz, P.; Jordan, I.; Genzel, Y.; Benndorf, D.; Reichl, U.: Quantification of intracellular influenza A virus proteins shows changes in dynamics related to host cell line and virus seed. 28th ESACT Meeting , Edingburgh (Scotland) (2024)

Küchler, J.; Opitz, P.; Jordan, I.; Genzel, Y.; Benndorf, D.; Reichl, U.: Quantification of intracellular influenza A virus proteins shows changes in dynamics related to host cell line and virus seed. Himmelfahrtstagung on Bioprocess Engineering 2024, Regensburg (Germany) (2024)

Pelz, L.; Dogra, T.; Rüdiger, D.; Boehme, J.; Kershaw, O.; Bruder, D.; Kupke, S. Y.; Reichl, U.: Defective Interfering Particles of Influenza A Virus As Broad-Spectrum Antivirals. 33^rd Annual Meeting of the Society for Virology (GfV), Vienna (Austria) (2024)

Piasecka, J.; Rüdiger, D.; Küchler, J.; Kupke, S. Y.; Reichl, U.: Mechanisms of antiviral action of the influenza defective interfering particle “OP7”. 33^rd Annual Meeting of the Society for Virology (GfV), Vienna (Austria) (2024)

Piasecka, J.; Rüdiger, D.; Küchler, J.; Kupke, S. Y.; Reichl, U.: Mechanisms of antiviral action of the influenza defective interfering particle “OP7”. 28th ESACT Meeting, Edinburgh (Scotland) (2024)

Rüdiger, D.; Opitz, P.; Kupke, S. Y.; Reichl, U.: A two-dimensional model to predict coinfection of influenza A virus with defective interfering particles in tissue-like systems. Himmelfahrtstagung on Bioprocess Engineering 2024, Regensburg (Germany) (2024)

Zinnecker, T. M.; Thiele, K.; Schmidberger, T.; Reichl, U.; Genzel, Y.: Influenza A Virus Production following Quality by Design Principles. Vaccine Technology IX, Los Cabos (Mexico) (2024)

Zinnecker, T. M.; Thiele, K.; Schmidberger, T.; Reichl, U.; Genzel, Y.: Implementation of Quality by Design Principles for Influenza A Virus Production. 28th ESACT Meeting, Edingburgh (Scotland) (2024)

Zuniga-Banuelos, F. J.; Hoffmann, M.; Reichl, U.; Rapp, E.: In-depth N glycoproteomic analysis reveals strategies to elucidate unanticipated N glycans in the low-abundant human blood plasma N glycoproteome. 23^rd Human Proteome Organization World Congress (HUPO World Congress), Dresden (Germany) (2024)

Göbel, S.: Production of a fusogenic oncolytic virus: In-depth process development and process intensification. Dissertation, Otto-von-Guericke-Universität, Magdeburg (2024)

Pelz, L.: In-depth characterization and cell culture-based production of influenza A virus defective interfering particles. Dissertation, Otto-von-Guericke-Universität, Magdeburg (2024)

Balapure, A.: Development of Downstream Processing Methods for Lipid-linked Oligosaccharides. Master, Technische Universität, München (2024)

Fattouh, N.: Process establishment of biocatalytic reaction networks for the synthesis of oligosaccharides. Master, Hochschule für Technik und Wirtschaft, Berlin (2024)