Publications BPE group

Coronel, J.; Gränicher, G.; Sandig, V.; Noll, T.; Genzel, Y.; Reichl, U.: Application of an Inclined Settler for Cell Culture-Based Influenza A Virus Production in Perfusion Mode. Frontiers in Bioengineering and Biotechnology 8, 672 (2020)

Duvigneau, S.; Dürr, R.; Laske, T.; Bachmann, M.; Dostert, M.; Kienle, A.: Model-based approach for predicting the impact of genetic modifications on product yield in biopharmaceutical manufacturing—Application to influenza vaccine production. PLoS Computational Biology 16 (6), e1007810 (2020)

Gränicher, G.; Coronel, J.; Trampler, F.; Jordan, I.; Genzel, Y.; Reichl, U.: Performance of an Acoustic Settler Versus a Hollow Fiber-Based ATF Technology for Influenza Virus Production in Perfusion. Applied Microbiology and Biotechnology 104 (11), pp. 4877 - 4888 (2020)

Heyer, R.; Klang, J.; Hellwig, P.; Schallert, K.; Kress, P.; Huelsemann, B.; Theuerl, S.; Reichl, U.; Benndorf, D.: Impact of feeding and stirring regimes on the internal stratification of microbial communities in the fermenter of anaerobic digestion plants. Bioresource Technology 314, 123679 (2020)

Hinneburg , H.; Pedersen, J. L.; Bokil, N. J.; Pralow, A.; Schirmeister, F.; Kawahara, R.; Rapp, E.; Saunders, B. M.; Thaysen-Andersen, M.: High-resolution Longitudinal N- And O-glycoprofiling of Human Monocyte-To- Macrophage Transition. Glycobiology 30 (9), pp. 679 - 694 (2020)

Kupke, S. Y.; Ly, L.-H.; Börno, S. T.; Ruff, A.; Timmermann, B.; Vingron, M.; Haas , S.; Reichl, U.: Single-Cell Analysis Uncovers a Vast Diversity in Intracellular Viral Defective Interfering RNA Content Affecting the Large Cell-to-Cell Heterogeneity in Influenza A Virus Replication. Viruses 12 (1), 71 (2020)

Leoz, D.; A., M. L.; Duewer, D. L.; Fung, A.; Liu, L.; Yau, H. K.; Potter, O.; Staples, G. O.; Furuki, K.; Frenkel, R. et al.; Hu, Y.; Sosic, Z.; Zhang, P.; Altmann, F.; Gruber, C.; Shao, C.; Zaia, J.; Evers, W.; Pangelley, S.; Suckau, D.; Wiechmann, A.; Resemann, A.; Jabs, W.; Beck, A.; Froehlich, J. W.; Huang, C.; Li, Y.; Liu, Y.; Sun, S.; Wang, Y.; Seo, Y.; An, H. J.; Reichardt, N.-C.; Ruiz, J. E.; Archer‑Hartmann, S.; Azadi, P.; Bell, L.; Lakos, Z.; An, Y.; Cipollo, J. F.; Pučić-Baković, M.; Štambuk, J.; Lauc, G.; Li, X.; Wang, P. G.; Bock, A.; Hennig, R.; Rapp, E.; Creskey, M.; Cyr, T.; Nakano, M.; Sugiyama, T.; Leung, P. A.; Link‑Lenczowski, P.; Jaworek, J.; Yang, S. J.; Zhang, H.; Kelly, T.; Klapoetke, S.; Cao, R.; Kim, J. Y.; Lee, H. K.; Lee, J.; Yoo, J. S.; Kim, S.; Suh, S.; de Haan, N.; Falck, D.; Lageveen-Kammeijer, G. S.M.; Wuhrer, M.; Emery, R. J.; Kozak, R. P.; Liew, L. P.; Royle, L.; Urbanowicz, P. A.; Packer, N.; Song, X.; Everest-Dass, A.; Lattová, E.; Cajic, S.; Alagesan, K.; Kolarich, D.; Kasali, T.; Lindo, V.; Chen, Y.; Goswami, K.; Gau, B.; Amunugama, R.; Jones, R.; Stroop, C. J. M.; Kato, K.; Yagi, H.; Kondo, S.; Yuen, C.; Harazono, A.; Shi, X.; Magnelli, P.; Kasper, B. T.; Mahal, L. K.; Harvey, D. J.; O'Flaherty, R.; Rudd, P. M.; Saldova, R.; Hecht, E. S.; Muddiman, D. C.; Kang, J.; Bhoskar, P.; Menard, D.; Saati, A.; Merle, C.; Mast, S.; Tep, S.; Truong, J.; Nishikaze, T.; Sekiya, S.; Shafer, A.; Funaoka, S.; Toyoda, M.; de Vreugd, P.; Caron, C.; Pradhan, P.; Tan, N. C.; Mechref, Y.; Patil, S.; Rohrer, J. S.; Chakrabarti, R.; Dadke, D.; Lahori, M.; Zou, C.; Cairo, C. W.; Reiz, B.; Whittal, R. M.; Lebrilla, C.; Wu, L. D.; Guttman, A.; Szigeti, M.; Kremkow, B. G.; Lee, K.; Sihlbom, C.; Adamczyk, B.; Jin, C.; Karlsson, N. G.; Örnros, J.; Larson, G.; Nilsson, J.; Meyer, B.; Wiegandt, A.; Komatsu, E.; Perreault, H.; Bodnar, E. D.; Said, N.; Francois, Y.; Leize-Wagner, E.; Maier, S.; Zeck, A.; Heck, A. J. R.; Yang, Y.; Haselberg, R.; Yu, Y. Q.; Alley, W.; Leone, J. W.; Yuan, H.; Stein, S. E.: NIST interlaboratory study on glycosylation analysis of monoclonal antibodies: comparison of results from diverse analytical methods. Molecular and Cellular Proteomics 19 (1), pp. 11 - 30 (2020)

Maus, I.; Tubbesing, T.; Wibberg, D.; Heyer, R.; Hassa, J.; Tomazetto, G.; Huang, L.; Bunk, B.; Spröer, C.; Benndorf, D. et al.; Zverlov, V.; Pühler, A.; Klocke, M.; Sczyrba, A.; Schlüter, A.: The Role of Petrimonas mucosa ING2-E5AT in Mesophilic Biogas Reactor Systems as Deduced from Multiomics Analyses. Microorganisms 8 (12), 2024 (2020)

Nikolay, A.; de Grooth, J.; Genzel, Y.; Wood, J. A.; Reichl, U.: Virus harvesting in perfusion culture: Choosing the right typeof hollow fiber membrane. Biotechnology and Bioengineering 117 (10), pp. 3040 - 3052 (2020)

Rexer, T.; Wenzel, L.; Hoffmann, M.; Tischlik, S.; Bergmann, C.; Grote, V.; Boecker, S.; Bettenbrock, K.; Schildbach, A.; Kottler, R. et al.; Mahour, R.; Rapp, E.; Pietzsch, M.; Reichl, U.: Synthesis of lipid-linked oligosaccharides by a compartmentalized multi-enzyme cascade for the in vitro N-glycosylation of peptides. Journal of Biotechnology 322 (10), pp. 54 - 65 (2020)

Rodrigues, A. F.; Fernandes, P.; Laske, T.; Castro, R.; Marques Alves, P.; Genzel, Y.; Coroadinha, A. S.: Cell Bank Origin of MDCK Parental Cells Shapes Adaptation to Serum-Free Suspension Culture and Canine Adenoviral Vector Production. International Journal of Molecular Sciences 21 (17), 6111 (2020)

Rodrigues Correia Ramos, J.; Rath, A.; Genzel, Y.; Sandig, V.; Reichl, U.: A dynamic model linking cell growth to intracellular metabolism and extracellular by‐product accumulation. Biotechnology and Bioengineering 117 (5), pp. 1533 - 1553 (2020)

Schaffert, A.; Hanić, M.; Novokmet, M.; Zaytseva, O.; Krištić, J.; Lux, A.; Nitschke, L.; Peipp, M.; Pezer, M.; Hennig, R. et al.; Rapp, E.; Lauc, G.; Nimmerjahn, F.: Minimal B Cell Extrinsic IgG Glycan Modifications of Pro- and Anti-Inflammatory IgG Preparations in vivo. Frontiers in Immunology 10, 3024 (2020)

Schiebenhoefer, H.; Schallert, K.; Renard, B. Y.; Trappe, K.; Schmid, E.; Benndorf, D.; Riedel, K.; Muth, T.; Fuchs, S.: A complete and flexible workflow for metaproteomics data analysis based on MetaProteomeAnalyzer and Prophane. Nature Protocols 15, pp. 3212 - 3239 (2020)

Scoma, A.; Khor, W. C.; Coma, M.; Heyer, R.; Props, R.; Schoelynk, J.; Bouts, T.; Benndorf, D.; Li, D.; Zhang, H. et al.; Rabaey, K.: Substrate-Dependent Fermentation of Bamboo in Giant Panda Gut Microbiomes: Leaf Primarily to Ethanol and Pith to Lactate. Frontiers in Microbiology 11, 530 (2020)

Van Den Bossche, T.; Verschaffelt, P.; Schallert, K.; Barsnes, H.; Dawyndt, P.; Benndorf, D.; Renard, B. Y.; Mesuere, B.; Martens, L.; Muth, T.: Connecting MetaProteomeAnalyzer and PeptideShaker to Unipept for Seamless End-to-End Metaproteomics Data Analysis. Journal of Proteome Research 19 (8), pp. 3562 - 3566 (2020)

Vogel , S. K.; Wölfer, C.; Ramirez-Diaz, D. A.; Flassig, R.; Sundmacher, K.; Schwille, P.: Symmetry breaking and emergence of directional flows in minimal actomyosin cortices. Cells 9 (6), 1432 (2020)

Bürgin, T.; Coronel, J.; Hagens, G.; Keebler, M. V.; Genzel, Y.; Reichl, U.; Anderlei, T.: Orbitally Shaken Single-Use Bioreactor for Animal Cell Cultivation: Fed-Batch and Perfusion Mode. In: Animal Cell Biotechnology, pp. 105 - 123 (Ed. Pörtner, R.). Humana, New York (2020)

Nikolay, A.; Bissinger, T.; Gränicher, G.; Wu, Y.; Genzel, Y.; Reichl, U.: Perfusion Control for High Cell Density Cultivation and Viral Vaccine Production. In: Animal Cell Biotechnology, pp. 141 - 168 (Ed. Pörtner, R.). Humana, New York (2020)

Beneyton , T.; Krafft, D.; Love, C.; Girault, M.; Bednarz, C.; Kleineberg, C.; Wölfer, C.; Ivanov, I.; Vidaković-Koch, T.; Sundmacher, K. et al.; Tang, D.; Baret, J.-C.: Droplet-based microfluidics for bottom-up synthetic biology. In 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2019), pp. 14 - 15. 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, Basel, Switzerland, October 27, 2019 - October 31, 2019. Curran Associates, Red Hook NY USA (2020)

Benndorf, D.: Was kann die Proteomik zur Klärung des Biogas-Metabolismus leisten? Abschlusssymposium des FNR/BMEL-Verbundvorhabens Modisto „Dynamik des Intermediat-Stoffwechsels in Biogasprozessen“, Virtual Meeting (2020)

Genzel, Y.: Process intensification for virus production: stirred or shaken perfusion leads to very high titres. World Vaccine Congress Washington, Virtual Meeting (2020)

Genzel, Y.: ESACT Course on Cell Culture-based Viral Vaccines (5^th Edition):Cells, Upstream Processing and Process Intensification. ESACT Course 2020, Virtual Meeting (2020)

Genzel, Y.: ESACT Course on Cell Culture-based Viral Vaccines (5^th Edition): Overview on COVID-19 candidate vaccines. ESACT Course 2020, Virtual Meeting (2020)

Genzel, Y.: ESACT Course on Cell Culture-based Viral Vaccines (5^th Edition): Exercise on COVID-19 antigen design options and vaccination platforms. ESACT Course 2020, Virtual Meeting (2020)

Genzel, Y.: ESACT Course on Cell Culture-based Viral Vaccines (5^th Edition): Exercise on COVID-19 vaccine manufacturing platforms and cost-effectiveness. ESACT Course 2020, Virtual Meeting (2020)

Genzel, Y.: ESACT Course on Cell Culture-based Viral Vaccines (5^th Edition): Exercise on COVID-19 vaccines immunology and protection. ESACT Course 2020, Virtual Meeting (2020)

Pelz, L.; Rüdiger, D.; Alnaji, F. G.; Genzel, Y.; Brooke, C. B.; Kupke, S. Y.; Reichl, U.: Evolution and selection of influenza a virus defective interfering particles in a semi-continuous production system for the use as antiviral. The seventh ESWI Influenza Conference, Virtual Meeting (2020)

Reichl, U.; Vazquez-Ramirez, D.; Tapia, F.; Nikolay, A.; Genzel, Y.: Cell Culture-based Viral Vaccines: Process Intensification and Monitoring. Plenarsitzung der Sächischen Akademie der Wissenschaften zu Leipzig, Leipzig, Germany (2020)

Rodrigues Correia Ramos, J.: A dynamic model for cell growth, metabolism and virus production of MDCK suspension cells. Society of Mathematical Biology Annual Meeting, Virtual Meeting (2020)

Rüdiger, D.; Pelz, L.; Hein, M.; Kupke, S. Y.; Reichl, U.: Multiscale model of DIP replication and its effects on influenza A virus infection in animal cell culture. Society for Mathematical Biology 2020 Annual Meeting, Virtual Meeting (2020)

Kupke, S. Y.; Hein, M. D.; Kollmus, H.; Marichal-Gallardo, P.; Schughart, K.; Reichl, U.: The novel influenza A virus defective interfering particle "OP7" as an antiviral agent: discovery, production, and animal trials. The seventh ESWI Influenza Conference, Virtual Meeting (2020)

Bissinger, T.: Evaluation of MDCK suspension cell lines for influenza A virus production: media, metabolism, and process conditions. Dissertation, Otto-von-Guericke-Universität, Magdeburg (2020)

Hoffmann, M.: In-Depth Mass Spectrometry-Based Glycoproteomics: Advances in Sample Preparation, Measurement and Data-Analysis of Glycoproteins. Dissertation, Otto-von-Guericke-Universität, Magdeburg (2020)

Nikolay, A.: Intensified yellow fever and Zika virus production in animal cell culture. Dissertation, Otto-von-Guericke-Universität, Magdeburg (2020)

Kupke, S. Y.: Single-cell analysis of influenza A virus replication: sources of cell-to-cell heterogeneity and discoverey of a novel type of defective interfering particle. Dissertation, Otto-von-Guericke-Universität, Magdeburg (2020)

Volk, V.: Optimization of Solid Phase Extraction for Purification of Fmoc Derivatized N-glycans. Master, Otto-von-Guericke-Universität, Magdeburg (2020)

Aydogan, T.: Mathematical modeling and optimization of an enzymatic cascade for the synthesis of UDP-GlcNAc. Master, Otto-von-Guericke Universität, Magdeburg (2020)

Gille, K.: Auswirkung von Prozessparametern auf die mikrobiellen Gemeinschaften in Biogasanlagen. Master, Otto-von-Guericke-Universität, Magdeburg (2020)

Buß, E.: Vergleich der Stuhlproben einer Probandengruppe vor und nach Gewichtsabnahme mit Hilfe LC-MS/MS basierter Metaproteomanalyse. Master, Otto-von-Guericke-Universität, Magdeburg (2020)

Göbel, S.: Process intensification for cell-culture based MVA production. Master, Universität Stuttgart, Stuttgart (2020)

Kirianova, O.: Development of a cell-free enzyme cascade for the synthesis of lipid-linked oligosaccharides with los cost substractes. Master, Friedrich-Schiller-Universität Jena, Jena (2020)

Nortmann, L.: Modeling de novo generation of defective interfering RNAs during influenza A virus replication. Master, Otto-von-Guericke-Universität, Magdeburg (2020)

Nuß, L.: Stabilität eines Pilzenzympräparates innerhalb von Biogasanlagen. Bachelor, Otto-von-Guericke-Universität, Magdeburg (2020)

Damm, M.: Erarbeitung einer Methode zur molekular biologischen Charakterisierung von Mikroorganismen aus Biogasprozessen. Bachelor, Otto-von-Guericke-Universität, Magdeburg (2020)

Grimpe, P.: Multienzyme systems for synthesis of activated sugars. Bachelor, Otto-von-Guericke Universität, Magdeburg (2020)

Kupke, S. Y.; Frensing, T.; Zmora, P.; Reichl, U.: Protective Interfering Nucleic Acid Molecule And Virus - Like Particle, Virsl Vector, or Virus Particle Containing the same as well as Pharmaceutical Composition Containing the Protective Interfering Nucleic Acid and its use. US 2020/0392504A1 (2020)

Rexer, T.; Mahour, R.: Enzymatic method for preparation of GDP-fucose. EP 3719135A1 (2020)