Publications of Y. Genzel
All genres
Journal Article (107)
2010
Journal Article
Janke, R., Genzel, Y., Wahl, A., & Reichl, U. (2010)Measurement of Key Metabolic Enzyme Activities in Mammalian Cells Using Rapid and Sensitive Microplate-Based AssaysBiotechnology and Bioengineering, 107 (3), 566–581doi: 10.1002/bit.22817.
Journal Article
Lohr, V., Genzel, Y., Behrendt, I., , & Reichl, U. (2010)A new MDCK suspension line cultivated in a fully defined medium in stirred-tank and wave bioreactorVaccine, 28 (38), 6256–6264doi: 10.1016/j.vaccine.2010.07.004.
Journal Article
, , Genzel, Y., Reichl, U., & (2010)Characterization of flow conditions in 2 L and 20 L wave bioreactors using Computational Fluid Dynamics.Biotechnology Progress, 26 (1), 101–110doi: 10.1002/btpr.312.
Journal Article
Ritter, J., Wahl, A., Freund, S., Genzel, Y., & Reichl, U. (2010)Metabolic effects of influenza virus infection in cultured animal cells: Intra- and extracellular metabolite profilingBMC Systems Biology, 4, 61doi: 10.1186/1752-0509-4-61.
Journal Article
Vester, D., Pflugmacher, A., , Seitz, C., Heldt, S., Bettenbrock, K., Genzel, Y., & Reichl, U. (2010)Real-time RT-qPCR assay for the analysis of human influenza A virus transcription and replication dynamicsJournal of Virological Methods, 168 (1-2), 63–71doi: 10.1016/j.jviromet.2010.04.017.
Journal Article
Vester, D., Rapp, E., Kluge, S., Genzel, Y., & Reichl, U. (2010)Virus-host cell interactions in vaccine production cell lines infected with different human influenza A virus variants: A proteomic approachJournal of Proteomics, 73 (9), 1656–1669doi: 10.1016/j.jprot.2010.04.006.
2009
Journal Article
Bock, A., Möhler, L., Sann, H., Schulze-Horsel, J., Genzel, Y., & Reichl, U. (2009)Growth behaviour of number distributed adherent MDCK cells for optimization in large scale microcarrier culturesBiotechnology Progress, 25 (6), 1717–1731doi: 10.1002/btpr.262.
Journal Article
Genzel, Y. & Reichl, U. (2009)Continuous cell lines as production system for influenza vaccinesExpert Review of Vaccines, 8 (12), 1681–1692doi: 10.1586/erv.09.128.
Journal Article
Lohr, V., Rath, A., Genzel, Y., , , & Reichl, U. (2009)New avian suspension cell lines provide production of influenza virus and MVA in serum-free media: studies on growth, metabolism and virus propagationVaccine, 27 (36), 4975–4982doi: 10.1016/j.vaccine.2009.05.083.
Journal Article
Schulze-Horsel, J., Schulze, M., Agalaridis, G., Genzel, Y., & Reichl, U. (2009)Infection dynamics and virus-induced apoptosis in cell culture-based influenza vaccine production – flow cytometry and mathematical modelingVaccine, 27 (20), 2712–2722doi: 10.1016/j.vaccine.2009.02.027.
Journal Article
Schwarzer, J., Rapp, E., Hennig, R., Genzel, Y., , , & Reichl, U. (2009)Glycan analysis in cell culture-based influenza vaccine production: Influence of host cell line and virus strain on the glycosylation pattern of viral hemagglutininVaccine, 27 (32), 4325–4336doi: 10.1016/j.vaccine.2009.04.076.
Journal Article
Vester, D., Rapp, E., , Genzel, Y., & Reichl, U. (2009)Quantitative analysis of cellular proteome alterations in human influenza A virus-infected mammalian cell linesProteomics, 9 (12), 3316–3327doi: 10.1002/pmic.200800893.
2008
Journal Article
Opitz, L., Zimmermann, A., Lehmann, S., Genzel, Y., , Reichl, U., & Wolff, M. W. (2008)Capture of cell culture-derived influenza virus by lectins: strain independent, but host cell dependentJournal of Virological Methods, 154 (1-2), 61–68doi: 10.1016/j.jviromet.2008.09.004.
Journal Article
Ritter, J. B., Genzel, Y., & Reichl, U. (2008)Simultaneous extraction of several metabolites of energy metabolism and related substances in mammalian cells: Optimization using experimental designAnalytical Biochemistry, 373, 349–369doi: 10.1016/j.ab.2007.10.037.
Journal Article
Schulze-Horsel, J., Genzel, Y., & Reichl, U. (2008)Flow cytometric monitoring of influenza A virus infection in MDCK cells during vaccine productionBMC Biotechnology, 8, 45doi: 10.1186/1472-6750-8-45.
Journal Article
Sidorenko, Y., Wahl, A., Dauner, M., Genzel, Y., & Reichl, U. (2008)Comparison of Metabolic Flux Distributions for MDCK Cell Growth in Glutamine- and Pyruvate-Containing MediaBiotechnology Progress, 24 (2), 311–320doi: 10.1021/bp0702673.
Journal Article
Wahl, A., Sidorenko, Y., , Genzel, Y., & Reichl, U. (2008)Metabolic flux model for an anchorage-dependent MDCK cell line: Characteristic Growth Phases and Minimum Substrate Consumption Flux DistributionBiotechnology and Bioengineering, 101 (1), 135–152doi: 10.1002/bit.21873.
2007
Journal Article
Hundt, B., , Schlawin, N., , Genzel, Y., & Reichl, U. (2007)Establishment of a mink enteritis vaccine production process in stirred-tank reactor and Wave Bioreactor microcarrier culture in 1-10 L scaleVaccine, 25 (20), 3987–3995doi: 10.1016/j.vaccine.2007.02.061.
Journal Article
Kalbfuss, B., Genzel, Y., Wolff, M. W., Zimmermann, A., , & Reichl, U. (2007)Harvesting and concentration of human influenza A virus produced in serum-free mammalian cell culture for the production of vaccinesBiotechnology and Bioengineering, 97 (1), 73–85doi: 10.1002/bit.21139.
2006
Journal Article
Genzel, Y., Fischer, M., & Reichl, U. (2006)Serum-free influenza virus production avoiding washing steps & medium exchange in large-scale microcarrier cultureVaccine, 24, 3261–3272doi: 10.1016/j.vaccine.2006.01.019.