Publications BPE group

Journal Article (27)

2019
Journal Article
Bdeir, N.; Arora, P.; Gärtner, S.; Hoffmann, M.; Reichl, U.; Pöhlmann, S.; Winkler, M.: A system for production of defective interfering particles in the absence of infectious influenza A virus. PLoS One 14 (3), e0212757 (2019)
Journal Article
Bissinger, T.; Fritsch, J.; Mihut, A. N.; Wu, Y.; Liu, X.; Genzel, Y.; Tan, W.-S.; Reichl, U.: Semi-perfusion cultures of suspension MDCK cells enable high cell concentrations and efficient influenza A virus production. Vaccine 37 (47), pp. 7003 - 7010 (2019)
Journal Article
Bule, P.; Chuzel, L.; Blagova, E.; Wu, L.; Gray, M. A.; Henrissat, B.; Rapp, E.; Bertozzi, C. R.; Taron, C. H.; Davies, G. J.: Inverting family GH156 sialidases define an unusual catalytic motif for glycosidase action. Nature Communications 10, 4816 (2019)
Journal Article
Campbell, M.P.; Abrahams, J.L.; Rapp, E.; Struwe, W.B.; Costello, C.E.; Novotny, M.; Ranzinger, R.; York, W.S.; Kolarich, D.; Rudd, P.M. et al.; Kettner, C.: The minimum information required for a glycomics experiment (MIRAGE) project: LC guidelines. Glycobiology 29 (5), pp. 349 - 354 (2019)
Journal Article
Coronel, J.; Behrendt, I.; Bürgin, T.; Anderlei, T.; Sandig, V.; Reichl, U.; Genzel, Y.: Influenza A virus production in a single-use orbital shaken bioreactor with ATF or TFF perfusion systems. Vaccine 37 (47), pp. 7011 - 7018 (2019)
Journal Article
Fischöder, T.; Cajic, S.; Grote, V.; Heinzler, R.; Reichl, U.; Franzreb, M.; Rapp, E.; Elling, L.: Enzymatic Cascades for Tailored 13C6 and 15N Enriched Human Milk Oligosaccharides. Molecules 24 (19), 3482 (2019)
Journal Article
Fischöder, T.; Cajic, S.; Reichl, U.; Rapp, E.; Elling , L.: Enzymatic cascade synthesis provides novel linear human milk oligosaccharides as reference standards for xCGE-LIF based high-throughput analysis. Biotechnology Journal 14 (3), 1800305 (2019)
Journal Article
Fortuna, A. R.; Van Teeffelen, S.; Ley, A.; Fischer, L. M.; Taft, F.; Genzel, Y.; Villain, L.; Wolff, M.; Reichl, U.: Use of sulfated cellulose membrane adsorbers for chromatographic purification of cell cultured-derived influenza A and B viruses. Separation and Purification Technology (226), pp. 350 - 358 (2019)
Journal Article
Gränicher, G.; Coronel, J.; Pralow, A.; Marichal-Gallardo, P.; Wolff, M. W.; Rapp, E.; Karlas, A.; Sandig, V.; Genzel, Y.; Reichl, U.: Efficient influenza A virus production in high cell density using the novel porcine suspension cell line PBG.PK2.1. Vaccine 37 (47), pp. 7019 - 7028 (2019)
Journal Article
Heyer, R.; Schallert, K.; Büdel, A.; Zoun, R.; Dorl, S.; Behne, A.; Kohrs, F.; Püttker, S.; Siewert, C.; Muth, T. et al.; Saake, G.; Reichl, U.; Benndorf, D.: A Robust and Universal Metaproteomics Workflow for Research Studies and Routine Diagnostics Within 24 h Using Phenol Extraction, FASP Digest, and the MetaProteomeAnalyzer. Frontiers in Microbiology 10, 1883 (2019)
Journal Article
Heyer, R.; Schallert, K.; Siewert, C.; Kohrs, F.; Greve, J.; Maus, I.; Klang, J.; Klocke, M.; Heiermann, M.; Hoffmann, M. et al.; Püttker, S.; Calusinska, M.; Zoun, R.; Saake, G.; Benndorf, D.; Reichl, U.: Metaproteome analysis reveals that syntrophy, competition, and phage-host interaction shape microbial communities in biogas plants. Microbiome (7), 69 (2019)
Journal Article
Hinneburg, H.; Chatterjee, S.; Schirmeister, F.; Nguyen-Khoung, T.; Packer, N.; Rapp, E.; Thaysen-Andersen, M.: Post-Column Make-Up Flow (PCMF) Enhances the Performance of Capillary-Flow PGC-LC-MS/MS-Based Glycomics. Analytical Chemistry 91 (7), pp. 4559 - 4567 (2019)
Journal Article
Koch, S.; Kohrs, F.; Lahmann, P.; Bissinger, T.; Wendschuh, S.; Benndorf, D.; Reichl, U.; Klamt, S.: RedCom: A strategy for reduced metabolic modeling of complex microbial communities and its application for analyzing experimental datasets from anaerobic digestion. PLoS Computational Biology 15 (2), e1006759 (2019)
Journal Article
Kupke, S. Y.; Riedel, D.; Frensing, T.; Zmora, P.; Reichl, U.: A Novel Type of Influenza A Virus-Derived Defective Interfering Particle with Nucleotide Substitutions in Its Genome. Journal of Virology 93 (4), 01786-18 (2019)
Journal Article
Laske, T.; Bachmann, M.; Dostert, M.; Karlas, A.; Wirth, D.; Frensing, T.; Meyer, T. F.; Hauser, H.; Reichl, U.: Model-based analysis of influenza A virus replication in genetically engineered cell lines elucidates the impact of host cell factors on key kinetic parameters of virus growth. PLoS Computational Biology 15 (4), e1006944 (2019)
Journal Article
Lehmann, T.; Schallert, K.; Vilchez-Vargas, R.; Benndorf, D.; Püttker, S.; Sydor, S.; Schulz, C. U.; Bechmann, L. P.; Canbay, A. E.; Heidrich, B. et al.; Reichl, U.; Link, A.; Heyer, R.: Metaproteomics of fecal samples of Crohn's disease and Ulcerative Colitis. Journal of Proteomics 201, pp. 93 - 103 (2019)
Journal Article
Munoz, R.I.; Kaehne, T.; Herrera, H.; Rodriguez, S.; Guerra, M.M.; Vio , K.; Hennig, R.; Rapp, E.; Rodriguez, E.: The subcommissural organ and the Reissner fiber: old friends revisited. Cell and Tissue Research 375 (2), pp. 507 - 529 (2019)
Journal Article
Reiding, K.R.; Bondt, A.; Hennig, R.; Gardner, R.A.; O'Flaherty, R.; Trbojević-Akmačić, I.; Shubhakar, A.; Hazes, J.; Reichl, U.; Fernandes, D.L. et al.; Pucic-Bakovic, M.; Rapp, E.; Spencer, D.I.R.; Dolhain, R.; Rudd, P.; Lauc, G.; Wuhrer, M.: High-throughput serum N-glycomics: method comparison and application to study rheumatoid arthritis and pregnancy-associated changes. Molecular and Cellular Proteomics 18 (1), pp. 3 - 15 (2019)
Journal Article
Rossdam, C.; Konze, S.; Oberbeck, A.; Rapp, E.; Gerardy-Schahn, R.; von Itzstein, M.; Buettner, F.: Approach for Profiling of Glycosphingolipid Glycosylation by Multiplexed Capillary Gel Electrophoresis Coupled to Laser-Induced Fluorescence Detection to Identify Cell-Surface Markers of Human Pluripotent Stem Cells and Derived Cardiomyocytes. Analytical Chemistry 91 (10), pp. 6413 - 6418 (2019)
Journal Article
Rüdiger, D.; Kupke, S. Y.; Laske, T.; Zmora, P.; Reichl, U.: Multiscale modeling of influenza A virus replication in cell cultures predicts infection dynamics for highly different infection conditions. PLoS Computational Biology 15 (2), e1006819 (2019)
Journal Article
Scoma, A.; Heyer, R.; Rifai, R.; Dandyk, C.; Marshall, I.; Kerckhof, F.-M.; Marietou, A.; Boshker, H. T. S.; Meysman, F. J. R.; Malmos, K. G. et al.; Vosegaard, T.; Vermeir, P.; Banat, I. M.; Benndorf, D.; Boon, N.: Reduced TCA cycle rates at high hydrostatic pressure hinder hydrocarbon degradation and obligate oil degraders in natural, deep-sea microbial communities. The ISME Journal 13 (4), pp. 1004 - 1018 (2019)
Journal Article
Tapia, F.; Laske, T.; Wasik, M.; Rammhold, M.; Genzel, Y.; Reichl, U.: Production of Defective Interfering Particles of Influenza A Virus in Parallel Continuous Cultures at Two Residence Times—Insights From qPCR Measurements and Viral Dynamics Modeling. Frontiers in Bioengineering and Biotechnology 7, 275 (2019)
Journal Article
Tapia, F.; Wohlfahrt, D.; Sandig, V.; Jordan, I.; Genzel, Y.; Reichl, U.: Continuous influenza virus production in a tubular bioreactor system provides stable titers and avoids the “von Magnus effect”. PLoS One 14 (11), e0224317 (2019)
Journal Article
Thorn, C.E.; Bergesch , C.; Joyce, A.; Sambrano, G.; McDonnell, K.; Brennan, F.; Heyer, R.; Benndorf, D.; Abram, F.: A robust, cost-effective method for DNA, RNA and protein co-extraction from soil, other complex microbiomes, and pure cultures. Molecular Ecology Resources 19 (2), pp. 439 - 455 (2019)
Journal Article
Vazquez-Ramirez, D.; Jordan, I.; Sandig, V.; Genzel, Y.; Reichl, U.: High titer MVA and influenza A virus production using a hybrid fed-batch/perfusion strategy with an ATF system. Applied Microbiology and Biotechnology 103 (7), pp. 3025 - 3035 (2019)
Journal Article
Weigel, T.; Soliman, R.; Wolff, M. W.; Reichl, U.: Hydrophobic-interaction chromatography for purification of influenza A and B virus. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 1117, pp. 103 - 117 (2019)
Journal Article
Weinrich, S.; Koch, S.; Bonk, F.; Popp, D.; Benndorf, D.; Klamt, S.; Centler, F.: Augmenting Biogas Process Modeling by Resolving Intracellular Metabolic Activity. Frontiers in Microbiology 10, 1095 (2019)

Book Chapter (1)

2019
Book Chapter
Hoffmann, D.; Leber, J.; Loewe, D.; Lothert, K.; Oppermann, T.; Zitzmann, J.; Weidner, T.; Salzig, D.; Wolff, M. W.; Czermak, P.: Purification of New Biologicals Using Membrane-Based Processes. In: Current Trends and Future Developments on (Bio-) Membranes, pp. 123 - 150 (Eds. Basile, A.; Charcosset, C.). Elsevier (2019)

Conference Paper (1)

2019
Conference Paper
Zoun, R.; Schallert, K.; Broneske, D.; Trifonova, I.; Chen, X.; Heyer, R.; Benndorf, D.; Saake, G.: Efficient transformation of protein sequence databases to columnar index schema. In: Database and Expert Systems Applications. DEXA 2019, pp. 67 - 72 (Ed. Anderst-Kotsis , G.). DEXA: International Conference on Database and Expert Systems Applications , Linz, Austria, August 26, 2019 - August 29, 2019. Springer, Cham, Switzerland (2019)

Meeting Abstract (3)

2019
Meeting Abstract
Hein, M.; Tapia, F.; Genzel, Y.; Kupke, S. Y.; Reichl, U.: Continuous mode of production for two classes of defective interfering influenza A virus particles as antiviral candidates. In Integrated Continuous Biomanufacturing IV, 76. Biomanufact IV, Ocean Edge Resort Brewster (Cape Cod), Massachusetts, USA , October 06, 2019 - October 10, 2019. (2019)
Meeting Abstract
Marichal-Gallardo, P.; Genzel, Y.; Börner, K.; Grimm, D.; Wolff, M. W.; Reichl, U.: A single-use chromatographic purification platform for viral gene transfer vectors & viral vaccines. In Proceedings Advancing Manufacture of Cell and Gene Therapies VI, 92. Advancing Manufacture of Cell and Gene Therapies VI, Loews Coronado Bay Hotel Coronado, California, USA, January 27, 2019 - January 31, 2019. (2019)
Meeting Abstract
Rexer, T.; Mathia, E.; Aplin, A.; Thomas, K.: High-pressure methane adsorption and characterization of pores in Posidonia shales and isolated kerogens. In Abstracts of Papers of the American Chemical Society, 258, 45-ENFL. ACS Fall National Meeting and Exposition, San Diego, CA, August 25, 2019 - August 29, 2019. (2019)

Talk (26)

2019
Talk
Benndorf, D.: Recent experimental and bioinformatic developments in metaproteomics. Metaproteomics - The Gateway to Microbial Commmunity Structure-Function Analysis, Sheffield, UK (2019)
Talk
Genzel, Y.: Next-generation production platforms for viral therapies. Simposio Max Planck / Fronteras de la Ciencia Bogotá, Bogota, Colombia (2019)
Talk
Genzel, Y.: Upstream Process Development - From Master Seed to Production. ESACT Cell culture based viral vaccine course, Llafranc, Spanien (2019)
Talk
Genzel, Y.: Upstream Process Intensification. ESACT Cell culture based viral vaccine course, Llafranc, Spanien (2019)
Talk
Genzel, Y.: Orbital Shaken Bioreactors: Perfusion with shaken bioreactors. Kühner Workshop Meeting, San Martin, Spain (2019)
Talk
Heyer, R.; Biermann, R.; Isermann, B.; Lehmann, T.; Buss, E.; Schallert, K.; Vilchez-Vargas, R.; Sydor, S.; Link, A.; Canbay, A. et al.; Reichl, U.; Benndorf, D.: System diagnostics of the human gut microbiome using metaproteome analysis of fecal samples. Deutscher Kongress für Laboratoriumsmedizin, Magdeburg, Germany (2019)
Talk
Heyer, R.; Schallert, K.; Püttker, S.; Kohrs, F.; Hellwig, P.; Theuerl, S.; Schlüter, A.; Reichl, U.; Benndorf, D.: Identification of process parameters shaping microbial communities in biogas plants using large scale metaproteome analysis. Annual Conference of the Association for General and Applied Microbiology (VAAM), Mainz, Germany (2019)
Talk
Hinneburg, H.; Schirmeister, F.; Nguyen-Khuong, T.; Packer, N.H.; Rapp, E.; Thayseb-Andersen, M.: Post-Column Make-up Flow (PCMF) Enhances the Sensitivity of Capillary-Flow PCG-LC-MS/Based Glycomics. GlycoBioTec 2019, Berlin, Germany (2019)
Talk
Khesali, H.; Amirhossein, A.; Benndorf, D.; Reichl, U.: Biological conversion of CO2 from a biogas plant to CH4. Young Professionals Conference on Process Engineering (YCOPE 2019), Magdeburg (2019)
Talk
Kupke, S. Y.; Riedel, D.; Frensing, T.; Zmora, P.; Reichl, U.: A novel type of defective interfering particle for antiviral therapy. 26th ESACT Meeting, Copenhagen, Denmark (2019)
Talk
Laske, T.; Tapia, F.; Wasik, M.; Rammhold, M.; Genzel, Y.; Reichl, U.: Production of defective interfering particles of influenza A virus in continuously cultured bioreactors at two residence times - insights from within-host virus dynamics. 4th Workshop on Viral Dynamics, Paris, France (2019)
Talk
Marichal-Gallardo, P.; Genzel, Y.; Börner, K.; Grimm, D.; Wolff, M.W.; Reichl, U.: A single-use chromatographic purification platform for viral gene transfer vectors & viral vaccines. ECI Advancing Manufacture of Cell and Gene Therapies VI, Coronado, United States of America (2019)
Talk
Nikolay, A.; Tapia, F.; Marichal-Gallardo, P.; Pralow, A.; Hoffmann, M.; Rapp, E.; Genzel, Y.; Reichl, U.: Moderne Methoden der Impfstoffherstellung. Wissenschaft im Rathaus, Magdeburg, Germany (2019)
Talk
Nikolay, A.; Tapia, F.; Marichal-Gallardo, P.; Pralow, A.; Hoffmann, M.; Rapp, E.; Genzel, Y.; Reichl, U.: Cell Culture-based Viral Vaccines: Process Intensification and Monitoring. Cuba Symposium “Frontiers of Science”, Havanna, Cuba (2019)
Talk
Rapp, E.; Hennig, R.; Cajic, S.; Behne , A.; Muth, T.; Kottler, R.; Reichl, U.: glyXbox CE: A powerful tool in the glycoanalytical toolbox - improving biologics development. GlycoBioTec 2019, Berlin, Germany (2019)
Talk
Reichl, U.: Dynamics of influenza A virus defective interfering particle replication. DARPA PI-Meeting, Arlington, United States of America (2019)
Talk
Reichl, U.: Dynamics of influenza A virus defective interfering particle replication. DARPA PI Meeting, New York, United States of America (2019)
Talk
Reichl, U.: High Yield Viral Vaccine Production: Process Options and Monitoring. 9th ISBioTech Spring Meeting, Norfolk, USA (2019)
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