Max Planck Institute for Dynamics of Complex Technical Systems

Publications of Steffen Klamt

All genres

Journal Article (117)

2018

Journal Article

Harder, B.-J., Bettenbrock, K., & Klamt, S. (2018)Temperature-dependent dynamic control of the TCA cycle increases volumetric productivity of itaconic acid production by Escherichia coli.Biotechnology and Bioengineering, 115 (1), 156–164doi: 10.1002/bit.26446.

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Journal Article

Klamt, S., Mahadevan, R., & Hädicke, O. (2018)When do two-stage processes outperform one-stage processes?Biotechnology Journal, 13 (2), 1700539doi: 10.1002/biot.201700539.

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Journal Article

Klamt, S., Müller, S., Regensburger, G., & Zanghellini, J. (2018)A mathematical framework for yield (versus rate) optimization in constraint-based modeling and applications in metabolic engineeringMetabolic Engineering, 47, 153–169doi: 10.1016/j.ymben.2018.02.001.

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Mahour, R., Klapproth, J., Rexer, T., Schildbach, A., Klamt, S., Pietzsch, M., Rapp, E., & Reichl, U. (2018)Establishment of a five-enzyme cell-free cascade for the synthesis of uridine diphosphate N-acetylglucosamineJournal of Biotechnology, 283, 120–129doi: 10.1016/j.jbiotec.2018.07.027.

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Journal Article

Venayak, N., Kamp von, A., Klamt, S., & Mahadevan, R. (2018)MoVE identifies metabolic valves to switch between phenotypic statesNature Communications, 9, 5332doi: 10.1038/s41467-018-07719-4.

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2017

Journal Article

Hädicke, O. & Klamt, S. (2017)EColiCore2: a reference model of the central metabolism of Escherichia coli and the relationships to its genome-scale parent modelScientific Reports, 7, 39647 doi: 10.1038/srep39647.

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Kamp von, A. & Klamt, S. (2017)Growth-coupled overproduction is feasible for almost all metabolites in five major production organisms.Nature Communications, 8, 15926 doi: 10.1038/ncomms15956.

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Kamp von, A., Thiele, S., Hädicke, O., & Klamt, S. (2017)Use of CellNetAnalyzer in biotechnology and metabolic engineeringJournal of Biotechnology, 261, 221–228doi: 10.1016/j.jbiotec.2017.05.001.

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Klamt, S., Regensburger, G., Gerstl, P. M., Jungreuthmayer, C., Schuster, S., Mahadevan, R., Zanghellini, J., & Müller, S. (2017)From elementary flux modes to elementary flux vectors: Metabolic pathway analysis with arbitrary linear flux constraintsPLoS Computational Biology, 13 (4), e1005409doi: 10.1371/journal.pcbi.1005409.

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2016

Journal Article

Gerstl, M. P., Klamt, S., Jungreuthmayer, C., & Zanghellini, J. (2016)Exact quantification of cellular robustness in genome-scale metabolic networksBioinformatics, 32 (5), 730–737doi: 10.1093/bioinformatics/btv649.

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publisher-version

Journal Article

Harder, B.-J., Bettenbrock, K., & Klamt, S. (2016)Model-Based metabolic engineering enables high yield itaconic acid production by Escherichia coliMetabolic Engineering, 38, 29–37doi: 10.1016/j.ymben.2016.05.008.

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Koch, S., Benndorf, D., Fronk, K., Reichl, U., & Klamt, S. (2016)Predicting compositions of microbial communities from stoichiometric models with applications for the biogas processBiotechnology for Biofuels, 9, 17doi: 10.1186/s13068-016-0429-x.

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Ud-Dean, S. M., Heise, S., Klamt, S., & Gunawan, R. (2016)TRaCE+: Ensemble inference of gene regulatory networks from transcriptional expression profiles of gene knock-out experiments.BMC Bioinformatics, 17 (17), 252doi: 10.1186/s12859-016-1137-z.

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Wu, H., Kamp von, A., Leoncikas, V., Mori, W., Sahin, M., Gevorgyan, A., Linley, C., Grabowski, M., Mannan, A. A., Stoy, N., Steward, G. R., Ward, L. T., Lewis, D. J. M., Sroca, J., Matsuno, H., Klamt, S., Westerhoff, H. V., McFadden, J., Plant, N. J., & Kierzek, A. M. (2016)MUFINS: multi-formalism interaction network simulatornpj Systems Biology and Applications, 2, 16032doi: 10.1038/npjsba.2016.32.

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2015

Journal Article

Bastiaens, P. I. H., Birtwistle, M. R., Blüthgen, N., Bruggeman, F. J., Cho, K.-H., de la Fuente, A., Hoek, J. B., Kiyatkin, A., Klamt, S., Kolch, W., Legewie, S., Mendes, P., Naka, T., Santra, T., Sontag, E., Westerhoff, H. V., & Kholodenko, B. N. (2015)Silence on the relevant literature and errors in implementationNature Biotechnology, 33 (4), 336–339doi: 10.1038/nbt.3185.

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D`Allessandro, L. A., Samaga, R., Maiwald, T., Rho, S.-H., Bonefas, S., Raue, A., Iwamoto, N., Kienast, A., Waldow, K., Meyer, R., Schilling, M., Timmer, J., Klamt, S., & Klingmüller, U. (2015)Disentangling the Complexity of HGF Signaling by Combining Qualitative and Quantitative ModelingPLoS Computational Biology, 11 (4), e1004192doi: 10.1371/journal.pcbi.1004192.

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Journal Article

Erdrich, P., Steuer, R., & Klamt, S. (2015)An algorithm for the reduction of genome-scale metabolic network models to meaningful core modelsBMC Systems Biology, 9, 48doi: 10.1186/s12918-015-0191-x.

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Journal Article

Hädicke, O., Bettenbrock, K., & Klamt, S. (2015)Enforced ATP futile cycling increases specific productivity and yield of anaerobic lactate production in Escherichia coliBiotechnology and Bioengineering, 112 (10), 2195–2199doi: 10.1002/bit.25623.

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Hädicke, O. & Klamt, S. (2015)Manipulation of the ATP pool as a tool for metabolic engineeringBiochemical Society Transactions (London), 43 (6), 1140–1145doi: 10.1042/BST20150141.

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Journal Article

Klamt, S. & Mahadevan, R. (2015)On the feasibility of growth-coupled product synthesis in microbial strainsMetabolic Engineering, 30, 166–178doi: 10.1016/j.ymben.2015.05.006.

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