Publications of Lars Pelz

Göbel, S., Pelz, L., Silva, C. A. T., Brühlmann, B., Hill, C., Altomonte, J., Kamen, A., Reichl, U., & Genzel, Y. (2024)Production of recombinant vesicular stomatitis virus-based vectors by tangential flow depth filtrationApplied Microbiology and Biotechnology, 108 (1), 240doi: 10.1007/s00253-024-13078-6.

Pelz, L., Dogra, T., Marichal-Gallardo, P., Hein, M. D., Hemissi, G., Kupke, S. Y., Genzel, Y., & Reichl, U. (2024)Production of antiviral “OP7 chimera” defective interfering particles free of infectious virusApplied Microbiology and Biotechnology, 108, 97doi: 10.1007/s00253-023-12959-6.

Dogra, T., Pelz, L., Boehme, J. D., Küchler, J., Kershaw, O., Marichal-Gallardo, P., Baelkner, M., Hein, M. D., Gruber, A. D., Benndorf, D., Genzel, Y., Bruder, D., Kupke, S. Y., & Reichl, U. (2023)Generation of “OP7 chimera” defective interfering influenza A particle preparations free of infectious virus that show antiviral efficacy in miceScientific Reports, 13, 20936doi: 10.1038/s41598-023-47547-1.

Pelz, L., Piagnani, E., Marsall, P., Wynserski, N., Hein, M. D., Marichal-Gallardo, P., Kupke, S. Y., & Reichl, U. (2023)Broad-Spectrum Antiviral Activity of Influenza A Defective Interfering Particles against Respiratory Syncytial, Yellow Fever, and Zika Virus Replication In VitroViruses, 15 (9), 1872doi: 10.3390/v15091872.

Pelz, L., Rüdiger, D., Dogra, T., Alnaji, F. G., Genzel, Y., Brooke, C. B., Kupke, S. Y., & Reichl, U. (2021)Semi-continuous propagation of influenza A virus and its defective interfering particles: analyzing the dynamic competition to select candidates for antiviral therapyJournal of Virology, 95 (24), e01174-21doi: 10.1128/JVI.01174-21.

Rüdiger, D., Pelz, L., Hein, M. D., Kupke, S. Y., & Reichl, U. (2021)Multiscale model of defective interfering particle replication for influenza A virus infection in animal cell culturePLoS Computational Biology, 17, e1009357doi: 10.1371/journal.pcbi.1009357.

Göbel, S., Pelz, L., Reichl, U., & Genzel, Y. (2023)Upstream processing for viral vaccines - Process intensificationBioprocessing of Viral Vaccines137–174.

Pelz, L., Göbel, S., Jaen , K., Reichl, U., & Genzel, Y. (2023)Upstream processing for viral vaccines – General aspectsBioprocessing of Viral Vaccines79–136.

Bälkner, M., Jeron, A., Volckmar, J., Pelz, L., Dogra, T., Kupke, S. Y., & Bruder, D. (2023)Characterization of the local innate immune response after mucosal application of IAV Defective Interfering ParticlesIn: European Journal of Immunology, P339doi: 10.1002/eji.202370300.

Göbel, S., Pelz, L., Behrendt, I., Prömmel, M., Altomonte, J., Anderlei, T., Bürgin, T., Genzel, Y., & Reichl, U. (2022)Scale-Down of an Ortbital Shaken Bioreactor: High Cell Density Cultivation in Perfusion Mode and Virus productionIn: Proceedings Single-Use Technologies V: Building the Future, 40.

Pelz, L., Dogra, T., Piasecka, J., Rüdiger, D., Bälkner, M., Boehme, J. D., Kershaw, O., Volckmar, J., Genzel, Y., Bruder, D., Kupke, S. Y., & Reichl, U.Influenza Vector-Based Defective Interfering Particles for Use as Broad-Spectrum Antiviral and Mucosal Live Vaccine: Construction, Production and in Vivo EfficacyPresented at: 34^th Annual Meeting of the Society for VirologyHamburg (Germany), March 4, 2025.

Pelz, L., Dogra, T., Piasecka, J., Rüdiger, D., Bälkner, M., Boehme, J. D., Volckmar, J., Bruder, D., Kupke, S. Y., & Reichl, U.Engineered influenza vectors for use as broadly-acting antivirals and live nasal vaccines: design, manufacture and in vivo efficacyPresented at: 9^th European Congress of Virology (ECV)Cavtat/Dubrovnik (Croatia), April 27, 2025.

Pelz, L., Rüdiger, D., Hein, M., Böhme, J., Bälkner, M., Kershaw, O., Marichal-Gallardo, P., Gruber, A., Genzel, Y., Bruder, D., Kupke, S. Y., & Reichl, U.Engineered defective interfering particles of influenza A virus for antiviral treatmentPresented at: 33^rd Annual Meeting of the Society for Virology (GfV)Vienna (Austria), March 25, 2023.

Pelz, L., Rüdiger, D., Hein, M. D., Böhme, J., Bälkner, M., Kershaw, O., Marichal-Gallardo, P., Gruber, A., Genzel, Y., Bruder, D., Kupke, S. Y., & Reichl, U.Genetic engineering of Influenza A virus defective interfering particles towards improved antiviral efficacy and potential use as a live vaccinePresented at: Vaccine Technology IXLos Cabos (Mexico), May 19, 2024.

Dogra, T., Pelz, L., Boehme, J. D., Baelkner, M., Kershaw, O., Marichal-Gallardo, P., Gruber, A. D., Genzel, Y., Bruder, D., Kupke, S. Y., & Reichl, U.Genetically engineered defective interfering particles of influenza A virus for antiviral treatment and vaccinationPresented at: 17^th Vaccine CongressGlasgow (Scotland), September 24, 2023.

Dogra, T., Pelz, L., Rüdiger, D., Kupke, S. Y., & Reichl, U.Reverse genetics for Influenza a virus to generate genetically engineered defective interfering particles for antiviral treatment and vaccinationPresented at: Vir-AI-DIP Workshop Hamburg (Germany), July 18, 2023.

Göbel, S., Jaén, K. E., Pelz, L., Reiter , M., Altomonte, J., Reichl, U., & Genzel, Y.Intensifiying OSB processes for high titer virus productionPresented at: 5^th large scale meeting: Orbital shaken bioreactorsGirona (Spain), June 5, 2023.

Kupke, S. Y., Dogra, T., Pelz, L., Hein, M. D., Ndeir, N., Rand, U., Boehme, J., Baelkner, M., Kershaw, O., Winkler, M., Cicin-Sain, L., Bruder, D., Pöhlmann, S., & Reichl, U.Influenza A virus defective interfering particles as antiviral agentsPresented at: 32^nd Annual Meeting of the Society for Virology (GfV)Ulm (Germany), March 28, 2023.

Pelz, L., Dogra, T., Boehme, J. D., Hein, M. D., Marichal-Gallardo, P., Genzel, Y., Bruder, D., Kupke, S. Y., & Reichl, U.Influenza A virus OP7 defective interfering particles: Cell culture-based production and antiviral efficacy in vivoPresented at: Cell Culture Engineering (CCE) XVIII Cancun (Mexico), April 23, 2023.

Pelz, L., Genzel, Y., Kupke, S. Y., & Reichl, U.In-depth characterization and cell culture-based production of influenza A virus defective interfering particlesPresented at: ACTIP fellowship sessionDublin (Ireland), October 11, 2023.