Analysis and Redesign of Biological Networks

Major research interests

Research in my group lies at the intersection of biology, mathematics, informatics, and the engineering sciences. We develop and apply novel computational methods to better understand structure and function of biological networks eventually enabling us to modify cellular behavior in a rational manner. As one particular focus, we are interested in modeling and computational design of metabolic networks for (systems) metabolic engineering of microbial cell factories. To test model-based predictions, our group performs wet-lab experiments (genetic modifications, bioreactors fermentations etc.) with Escherichia coli, one of the most important model organisms serving as host in many biotechnological production processes. Our group developed the comprehensive MATLAB package CellNetAnalyzer (and recently its Python-based Variant CNApy) which provide a graphical user interface and numerous algorithms for analyzing and designing metabolic networks.

Possible research projects (not exhaustive)

Microbial biopolymer and platform chemicals production from biogenic residues
(Collaboration partners: Prof. Kienle, Dr. Bettenbrock)
Flux-balance and sustainability analysis of the carbon metabolism(s) of the chemical industry
(Collaboration partners: Prof. Sundmacher, hon. Prof. Rihko-Struckmann)