Analysis and Redesign of Biological Networks
It is nowadays widely accepted that understanding the complexity of life at the cellular level requires mathematical tools. Consequently, interdisciplinary research fields such as Systems and Computational Biology have emerged. Along this line, the primary research interests of our group lie at the intersection of biology, mathematics, and engineering sciences and the group’s main goal is to obtain a network and systems view of the cell. We develop computational methods and tools for modeling, analysis, and data-driven inference of bio-molecular networks. From an engineer’s perspective, we are also interested in using models to calculate suitable intervention strategies that change the behavior of a cell towards a desired behavior.
In collaborations with experimental partners we study realistic cellular systems in an iterative cycle of wet and dry lab investigations. Application examples include the data-driven elucidation of signaling network topologies or the rational (re)design of bacterial metabolic networks towards bio-based production of certain chemicals. The group also has an experimental research team studying specific aspects of metabolic regulation and metabolic engineering in the model bacterium E. coli.
Overall, a long-term vision of the ARB group is to help pave the way for routine use of mathematical modeling and network analysis in biology, biotechnology, and biomedicine.
A detailed description of our research activities can be found here
Keywords: Systems Biology, Computational Biology, Bioinformatics, Metabolic Engineering, Signal Transduction Networks, Metabolic Networks, Gene Regulatory Networks, Escherichia coli