Publications of Alexander Rath

Rodrigues Correia Ramos, J.; Rath, A.; Genzel, Y.; Sandig, V.; Reichl, U.: A dynamic model linking cell growth to intracellular metabolism and extracellular by‐product accumulation. Biotechnology and Bioengineering 117 (5), pp. 1533 - 1553 (2020)

Cammann, C.; Rath, A.; Reichl, U.; Lingel, H.; Brunner-Weintierl, M.; Simeoni, L.; Schraven, B.; Lindquist, J. A.: Early changes in the metabolic profile of activated CD8+ T cells. BMC Biology 17 (1), 28 (2016)

Rath, A.; Rehberg, M.; Janke, R.; Genzel, Y.; Scholz, S.; Noll, T.; Rose, T.; Sandig, V.; Reichl, U.: The influence of cell growth and enzyme activity changes on intracellular metabolite dynamics in AGE1.HN.AAT cells. Journal of Biotechnology 178, pp. 43 - 53 (2014)

Rehberg, M.; Rath, A.; Ritter, J.; Genzel, Y.; Reichl, U.: Changes in intracellular metabolite pools during growth of adherent MDCK cells in two different media. Applied Microbiology and Biotechnology 98 (1), pp. 385 - 397 (2014)

Borchers, S.; Freund, S.; Rath, A.; Streif, S.; Reichl, U.; Findeisen, R.: Identification of Growth Phases and Influencing Factors in Cultivations with AGE1.HN Cells Using Set-Based Methods. PLoS One 8 (8), e68124 (2013)

Freund, S.; Rath, A.; Barradas, O. P.; Skerhutt, S.; Scholz, S.; Niklas, J.; Sandig, V.; Rose, T.; Heinzle, E.; Noll, T. et al.; Pörtner, R.; Zeng, A. P.; Reichl, U.: Batch-to-batch variability of two human designer cell lines - AGE1.HN and AGE1.HN.AAT - carried out by different laboratories under defined culture conditions using a mathematical model. Engineering in Life Sciences 13 (6), pp. 580 - 592 (2013)

Platas Barradas, O.; Jandt, U.; Da Minh Phan, L.; Villanueva, M. E.; Schaletzky, M.; Rath, A.; Freund, S.; Reichl, U.; Skerhutt, E.; Scholz, S. et al.; Noll, T.; Sandig, V.; Pörtner, R.; Zeng, A.-P.: Evaluation of criteria for bioreactor comparison and operation standardization for mammalian cell culture. Engineering in Life Sciences 12 (5), pp. 518 - 528 (2012)

Lohr, V.; Rath, A.; Genzel, Y.; Jordan, I.; Sandig, V.; Reichl, U.: New avian suspension cell lines provide production of influenza virus and MVA in serum-free media: studies on growth, metabolism and virus propagation. Vaccine 27 (36), pp. 4975 - 4982 (2009)

Lohr, V.; Rath, A.; Jordan, I.; Sandig, V.; Genzel, Y.; Reichl, U.: Avian Designer Cells AGE1.CR as Candidates for MVA and Influenza Vaccine Production. In: ESACT - Proceedings of the 21st Annual meeting of the European Society for animal cell technology (ESACT), pp. 615 - 631 (Eds. Jenkins, N.; Barron, N.; Alves, P.). 21st ESACT Meeting, Dublin, Ireland, June 07, 2009 - June 10, 2009. (2012)

Barradas, O.P.; Jandt, U.; Phan, L.D.; Villanueva, M.; Rath, A.; Reichl, U.; Schräder, E.; Scholz, S.; Noll, T.; Sandig, V. et al.; Pörtner, R.; Zeng, A.P.: Criteria for bioreactor comparison and operation standardisation during process development for mammalian cell culture. In BMC Proceedings, 5 (S8), P47. 22nd European Society for Animal Cell Technology (ESACT) - Meeting on Cell Based Technologies , Vienna, Austria, May 15, 2011 - May 18, 2011. (2011)

Scholz, S.; Luebbecke, M.; Rath, A.; Schraeder, E.; Rose, T.; Büntemeyer, H.; Scheper, T.; Reichl, U.; Noll, T.: Characterization of the human AGE1.HN cell line: a systems biology approach. In BMC Proceedings, 5 (S8 ), P78. 22nd European Society for Animal Cell Technology (ESACT) - Meeting on Cell Based Technologies , Vienna, Austria, May 15, 2011 - May 18, 2011. (2011)

Schräder, E.; Scholz, S.; Niklas, J.; Rath, A.; Barradas, O.P.; Jandt, U.; Sandig, V.; Rose, T.; Pörtner, R.; Reichl, U. et al.; Zeng, A.P.; Heinzle, E.; Noll, T.: Characterisation of cultivation of the human cell line AGE1.HN.AAT. In BMC Proceedings, 5 (S8), P87. 22nd European Society for Animal Cell Technology (ESACT) - Meeting on Cell Based Technologies , Vienna, Austria, May 15, 2011 - May 18, 2011. (2011)

Rath, A.; Scholz, S.; Noll, T.; Janke, R.; Genzel, Y.; Rose, T.; Sandig, V.; Reichl, U.: Insights into mammalian energy metabolism: connecting intracellular metabolites and maximum enzyme activities. GVC/DECHEMA Vortrags- und Diskussionstagung - Biopharmazeutische Produktion, Freiburg (2012)

Lohr, V.; Rath, A.; Jordan, I.; Sandig, V.; Genzel, Y.; Reichl, U.: Avian designer cells AGE1.CR: possible candidates for MVA and influenza vaccine production? 21st ESACT Meeting, Dublin, Ireland (2009)

Rath, A.; Lohr, V.; Genzel, Y.; Schwarzer, J.; Rapp, E.; Sandig, V.; Jordan, I.; Reichl, U.: Influenza and modified vaccinia Ankara (MVA) production in avian designer cells. Bioperspectives, Hannover, Germany (2008)

Rodrigues Correia Ramos, J.; Rath, A.; Genzel, Y.; Rose, T.; Sandig, V.; Reichl, U.: A Dynamic Model of Growth and Metabolism of AGE1.HN Suspension Cells. 6th IFAC Conference on Foundations of Systems Biology in Engineering (FOSBE), Magdeburg, Germany (2016)

Blechert, A.-K.; Rath, A.; Sann, H.; Spaner, D.; Coroadinha, A.S.; Genzel, Y.; Reichl, U.: Towards an analytical platform for metabolic studies in adherent and suspension cells: intracellular metabolite concentrations and maximum enzyme activities. 23rd ESACT Meeting, Lille, France (2013)

Freund, S.; Rath, A.; Rose, T.; Sandig, V.; Reichl, U.: Metabolic Flux Analysis of AAT Production in AGE1.HN.AAT Cells under Different Cultivation Conditions. ESBES - 9 th European Symposium on Biochemical Engineering Science, Istanbul (2012)

Freund, S.; Rath, A.; Sandig, V.; Rose, T.; Reichl, U.: Comparison of the productivity of a new human cell line in different steady states of continuous cultivations using MFA. Metabolic Engineering IX, Biarritz, France (2012)

Freund, S.; Rath, A.; Sandig, V.; Rose, T.; Reichl, U.: AGE1.HN.AAT - growth of a human cell line in glucose excess and limitation: comparison of different metabolic states via stationary metabolic flux analysis. 22nd ESACT Meeting, Vienna, Austria (2011)