Publications of Frank Stefan Heldt

Laske, T.; Heldt, F. S.; Hoffmann, H.; Frensing, T.; Reichl, U.: Modeling the intracellular replication of influenza A virus in the presence of defective interfering RNAs. Virus Research 213, pp. 90 - 99 (2016)

Laske, T.; Heldt, S.; Hoffmann, H.; Frensing, T.; Reichl, U.: Reprint of “Modeling the intracellular replication of influenza A virus in the presence of defective interfering RNAs. Virus Research 218, pp. 86 - 95 (2016)

Heldt, F. S.; Kupke, S. Y.; Dorl, S.; Frensing, T.; Reichl, U.: Single-cell analysis and stochastic modelling unveil large cell-to-cell variability in influenza A virus infection. Nature Communications 6, 8938 (2015)

Frensing, T.; Heldt, S.; Pflugmacher, A.; Behrendt, I.; Jordan, I.; Flockerzi, D.; Genzel, Y.; Reichl, U.: Continuous Influenza Virus Production in Cell Culture Shows a Periodic Accumulation of Defective Interfering Particles. PLoS One 8 (9), e72288 (2013)

Heldt, S.; Frensing, T.; Pflugmacher, A.; Gröpler, R.; Peschel, B.; Reichl, U.: Multiscale Modeling of Influenza A Virus Infection Supports the Development of Direct-Acting Antivirals. PLoS Computational Biology 9 (11), e1003372 (2013)

Heldt, F. S.; Frensing, T.; Reichl, U.: Modeling the intracellular dynamics of influenza virus replication to understand the control of viral RNA synthesis. Journal of Virology 86 (15), pp. 7806 - 7817 (2012)

Vester, D.; Pflugmacher, A.; Hoffmann, D.; Seitz, C.; Heldt, S.; Bettenbrock, K.; Genzel, Y.; Reichl, U.: Real-time RT-qPCR assay for the analysis of human influenza A virus transcription and replication dynamics. Journal of Virological Methods 168 (1-2), pp. 63 - 71 (2010)

Kupke, S. Y.; Heldt, S.; Frensing, T.; Reichl, U.: Single-Cell Analysis of Influenza A Virus-Infected Cells. 26th Annual Meeting of the Society for Virology, Münster, Germany (2016)

Kupke, S. Y.; Heldt, S.; Frensing, T.; Reichl, U.: Heterogeneity in Influenza A Virus Infection Unveiled by Single-Cell Analysis and Stochastic Mathemeatical Modeling. Single Cell Technologies 2016, Frankfurt/Main (2016)

Kupke, S. Y.; Heldt, S.; Frensing, T.; Reichl, U.: Single-Cell Analysis of Influenza A Virus-Infected Cells for the Optimization of Cell Culture-Based Vaccine Production. Vaccine Technology VI, Albufeira, Portugal (2016)

Laske, T.; Heldt, F. S.; Frensing, T.; Reichl, U.: Analyzing the dynamics of influenza A virus replication in the presence of defective interfering RNAs. 2nd Workshop on Virus Dynamics, Toronto, Ontario, Canada (2015)

Heldt, S.; Frensing, T.; Reichl, U.: The multiscale nature of influenza A virus infection and its implications for modeling antiviral therapy. The Joint Annual Meeting of the Japanese Society for Mathematical Biology and the Society for Mathematical Biology, Osaka, Japan (2014)

Heldt, S.; Isken, B.; Pflugmacher, A.; Frensing, T.; Reichl, U.: Multi-scale modeling of influenza virus infection elucidates the performance of antivirals. 1st Workshop on Virus Dynamics (DECHEMA), Frankfurt/Main, Germany (2013)

Heldt, S.; Peschel, B.; Frensing, T.; Reichl, U.: Multiscale modeling of influenza virus infection supports the development of antiviral drugs. 14th International Conference on Systems Biology , Copenhagen (Denmark) (2013)

Heldt, F. S.; Frensing, T.; Reichl, U.: Elucidating bottlenecks in influenza virus replication to optimize vaccine production. International Conference on the Systems Biology of Human Disease, Heidelberg, Germany (2012)

Heldt, F. S.; Reichl, U.: Understanding the dynamics of intracellular virus replication - How does Influenza control its RNA and protein synthesis? 4th ESWI Influenza Conference, Malta (2011)

Laske, T.; Heldt, F. S.; Hoffmann, H.; Frensing, T.; Reichl, U.: Modeling the intracellular replication of influenza A virus in the presence of defective interfering RNAs. 26th Annual Meeting of the Society for Virology, Münster, Germany (2016)

Rüdiger, D.; Heldt, S.; Kupke, S. Y.; Reichl, U.: Stochastic multiscale modeling of influenza virus production in cell cultures. Poster presented at 6th IFAC Conference on Foundations of Systems Biology in Engineering. 6th IFAC Conference on Foundations of Systems Biology in Engineering (FOSBE), Magdeburg, Germany (2016)

Rüdiger, D.; Heldt, S.; Kupke, S. Y.; Reichl, U.: Stochastic multiscale modeling of influenza virus production in cell cultures. 6th IFAC Conference on Foundations of Systems Biology in Engineering (FOSBE), Magdeburg, Germany (2016)

Kupke, S. Y.; Heldt, F.S.; Frensing, T.; Reichl, U.: Single Cell Analysis of Influenza A Virus-infected Cells for the Optimization of Cell Culture-based Vaccine Manufacturing Processes. ESACT 2015, Barcelona, Spain (2015)