Human Blood N-Glycoproteomics

The aim of this project is to detect disease-associated differences in the N-glycosylation of blood plasma glycoproteins derived from cohorts of clinical interest. It is intended that an in-depth N-glycoproteomic analysis will provide insights into the occupancy of N-glycosylation sites per protein (macro-heterogeneity), including the diversity and abundance of N-glycans bound to each N-glycosylation site (micro-heterogeneity). Through an integrative statistical analysis of N-glycoproteomic datasets it is anticipated to detect N-glycosylation-based biomarkers (Figure 1).

Publications