Institute for Experimental Internal Medicine
The Systems Biology Laboratory investigates dynamic regulation and control mechanisms of cellular signal transduction networks by a combination of theoretical, experimental and computational methods. We seek to make sense of our biological data with the help of mathematical models, which ideally enable us to make valid predictions for new experiments, thereby generating novel biological insights. We are an interdisciplinary team of molecular biologists, physicists, mathematicians and engineers, and accordingly we use a broad spectrum of experimental, analytical and computational tools, which are partly developed in the group. We mainly study eukariotic systems in the following projects: SysDamSen: Systems biology of DNA-damage induced premature cellular senescence CytoSen: Exploring the links between cytokine signalling and cellular senescence and their implications for cancer therapies Robustness of feedback control in cellular networks Signalling crosstalk during response to hyper- and hypo- osmotic shock in yeast Arsenite stress response in yeast The role of NFI in growth-dependent regulation of gene expression.