Publications of Tanja Laske

Duvigneau, S.; Dürr, R.; Laske, T.; Bachmann, M.; Dostert, M.; Kienle, A.: Model-based approach for predicting the impact of genetic modifications on product yield in biopharmaceutical manufacturing—Application to influenza vaccine production. PLoS Computational Biology 16 (6), e1007810 (2020)

Rodrigues, A. F.; Fernandes, P.; Laske, T.; Castro, R.; Marques Alves, P.; Genzel, Y.; Coroadinha, A. S.: Cell Bank Origin of MDCK Parental Cells Shapes Adaptation to Serum-Free Suspension Culture and Canine Adenoviral Vector Production. International Journal of Molecular Sciences 21 (17), 6111 (2020)

Laske, T.; Bachmann, M.; Dostert, M.; Karlas, A.; Wirth, D.; Frensing, T.; Meyer, T. F.; Hauser, H.; Reichl, U.: Model-based analysis of influenza A virus replication in genetically engineered cell lines elucidates the impact of host cell factors on key kinetic parameters of virus growth. PLoS Computational Biology 15 (4), e1006944 (2019)

Rüdiger, D.; Kupke, S. Y.; Laske, T.; Zmora, P.; Reichl, U.: Multiscale modeling of influenza A virus replication in cell cultures predicts infection dynamics for highly different infection conditions. PLoS Computational Biology 15 (2), e1006819 (2019)

Tapia, F.; Laske, T.; Wasik, M.; Rammhold, M.; Genzel, Y.; Reichl, U.: Production of Defective Interfering Particles of Influenza A Virus in Parallel Continuous Cultures at Two Residence Times—Insights From qPCR Measurements and Viral Dynamics Modeling. Frontiers in Bioengineering and Biotechnology 7, 275 (2019)

Laske, T.; Heldt, S.; Hoffmann, H.; Frensing, T.; Reichl, U.: Reprint of “Modeling the intracellular replication of influenza A virus in the presence of defective interfering RNAs. Virus Research 218, pp. 86 - 95 (2016)

Castro, R.; Fernandes, P.; Laske, T.; Sousa, M. F. Q.; Genzel, Y.; Scharfenberg, K.; Alves, P.M.; Coroadinha, A.S.: Production of canine adenovirus type 2 in serum-free suspension cultures of MDCK cells. Applied Microbiology and Biotechnology 99 (17), pp. 7059 - 7068 (2015)

Peschel, B.; Frentzel, S.; Laske, T.; Genzel, Y.; Reichl, U.: Comparison of influenza virus yields and apoptosis-induction in an adherent and a suspension MDCK cell line. Vaccine 31 (48), pp. 5693 - 5699 (2013)

Duvigneau, S.; Dürr, R.; Laske, T.; Bachmann, M.; Dostert, M.; Reichl, U.; Kienle, A.: Mathematical modeling as a tool to improve influenza vaccine production processes. FOSBE 2018, Chicago, Illinois, USA, August 05, 2018 - August 08, 2018. IFAC-PapersOnLine 51 (19), pp. 1 - 4 (2018)

Dürr, R.; Duvigneau, S.; Laske, T.; Bachmann, M.; Kienle, A.: Analyzing the Impact of Heterogeneity in Genetically Engineered Cell Lines for Influenza Vaccine Production Using Population Balance Modeling. Foundations of Systems Biology in Engineering - FOSBE 2016 — Magdeburg, Germany, 9—12 October 2016, Magdeburg, Germany, October 09, 2016 - October 12, 2016. IFAC-PapersOnLine 49 (26), pp. 225 - 230 (2016)

Fernandes, P.; Castro, R.; Laske, T.; Genzel, Y.; Kremer, E.; Alves, P.; Coroadinha, A.: The impact of MDCK cell source on the production of influenza and canine adenovirus. In New Biotechnology: Abstracts of the 16th European Congress on Biotechnology, 31 Supplement, p. S180. (2014)

Laske, T.; Tapia, F.; Wasik, M.; Rammhold, M.; Genzel, Y.; Reichl, U.: Production of defective interfering particles of influenza A virus in continuously cultured bioreactors at two residence times - insights from within-host virus dynamics. 4th Workshop on Viral Dynamics, Paris, France (2019)

Rüdiger, D.; Laske, T.; Kupke, S. Y.; Reichl, U.: Multiscale model of DIP interference and production during influenza A virus infection in animal cell culture. 4th Workshop on Virus Dynamics, Paris, France (2019)

Duvigneau, S.; Dürr, R.; Laske, T.; Bachmann, M.; Dostert, M.; Reichl, U.; Kienle, A.: Mathematical modeling as a tool to improve influenza vaccine production processes. FOSBE 2018, Chicago, Illinois, USA (2018)

Laske, T.; Bachmann, M.; Dostert, M.; Karlas, A.; Wirth, D.; Frensing, T.; Reichl, U.: Model-based characterization of influenza A virus production in genetically engineered cell lines elucidates changes in virus replication. 3rd Workshop on Virus Dynamics, Heidelberg, Germany (2017)

Laske, T.; Bachmann, M.; Frensing, T.; Reichl, U.: Model-based analysis of influenza A virus replication in genetically modified cell lines elucidates virus-host cell interactions. 1st ESACT Frontiers Retreat, Lyon, France (2016)

Laske, T.; Heldt, F. S.; Frensing, T.; Reichl, U.: Analyzing the dynamics of influenza A virus replication in the presence of defective interfering RNAs. 2nd Workshop on Virus Dynamics, Toronto, Ontario, Canada (2015)

Laske, T.: Mathematical modeling of virus-host cell interactions during influenza virus replication supports cell line development for vaccine production. Workshop on Virus Dynamics and Evolution des Centre De Recerca Matemàtica (CRM), Bellaterra, Spain (2014)

Rüdiger, D.; Laske, T.; Kupke, S. Y.; Reichl, U.: A multiscale model of defective interfering particle replication. FOSBE 2019, Valencia, Spain (2019)

Laske, T.; Bachmann, M.; Dostert, M.; Frensing, T.; Karlas, A.; Wirth, D.; Reichl, U.: Modeling reveals changes in key parameters of infuenza A virus replication in engineered cell lines. 11th Annual International Conference on Systems Biology of Human Diseases, Los Angeles, USA (2018)