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Journal Article (4)

2020
Journal Article
Duvigneau, S.; Dürr, R.; Laske, T.; Bachmann, M.; Dostert, M.; Kienle, A.: Model-based approach for predicting the impact of genetic modifications on product yield in biopharmaceutical manufacturing—Application to influenza vaccine production. PLoS Computational Biology 16 (6), e1007810 (2020)
2019
Journal Article
Laske, T.; Bachmann, M.; Dostert, M.; Karlas, A.; Wirth, D.; Frensing, T.; Meyer, T. F.; Hauser, H.; Reichl, U.: Model-based analysis of influenza A virus replication in genetically engineered cell lines elucidates the impact of host cell factors on key kinetic parameters of virus growth. PLoS Computational Biology 15 (4), e1006944 (2019)
2016
Journal Article
Bachmann, M.; Breitwieser, T.; Lipps, C.; Wirth, D.; Jordan, I.; Reichl, U.; Frensing, T.: Impaired antiviral response of adenovirus-transformed cell lines supports virus replication. Journal of General Virology 97 (2), pp. 293 - 298 (2016)
Journal Article
Frensing, T.; Kupke, S. Y.; Bachmann, M.; Fritzsche, S.; Gallo Ramirez, L. E.; Reichl, U.: Influenza virus intracellular replication dynamics, release kinetics, and particle morphology during propagation in MDCK cells. Applied Microbiology and Biotechnology 100 (16), pp. 7181 - 7192 (2016)

Conference Paper (2)

2018
Conference Paper
Duvigneau, S.; Dürr, R.; Laske, T.; Bachmann, M.; Dostert, M.; Reichl, U.; Kienle, A.: Mathematical modeling as a tool to improve influenza vaccine production processes. FOSBE 2018, Chicago, Illinois, USA, August 05, 2018 - August 08, 2018. IFAC-PapersOnLine 51 (19), pp. 1 - 4 (2018)
2016
Conference Paper
Dürr, R.; Duvigneau, S.; Laske, T.; Bachmann, M.; Kienle, A.: Analyzing the Impact of Heterogeneity in Genetically Engineered Cell Lines for Influenza Vaccine Production Using Population Balance Modeling. Foundations of Systems Biology in Engineering - FOSBE 2016 — Magdeburg, Germany, 9—12 October 2016, Magdeburg, Germany, October 09, 2016 - October 12, 2016. IFAC-PapersOnLine 49 (26), pp. 225 - 230 (2016)

Talk (2)

2017
Talk
Laske, T.; Bachmann, M.; Dostert, M.; Karlas, A.; Wirth, D.; Frensing, T.; Reichl, U.: Model-based characterization of influenza A virus production in genetically engineered cell lines elucidates changes in virus replication. 3rd Workshop on Virus Dynamics, Heidelberg, Germany (2017)
2016
Talk
Laske, T.; Bachmann, M.; Frensing, T.; Reichl, U.: Model-based analysis of influenza A virus replication in genetically modified cell lines elucidates virus-host cell interactions. 1st ESACT Frontiers Retreat, Lyon, France (2016)

Poster (8)

2018
Poster
Laske, T.; Bachmann, M.; Dostert, M.; Frensing, T.; Karlas, A.; Wirth, D.; Reichl, U.: Modeling reveals changes in key parameters of infuenza A virus replication in engineered cell lines. 11th Annual International Conference on Systems Biology of Human Diseases, Los Angeles, USA (2018)
2016
Poster
Dürr, R.; Duvigneau, S.; Laske, T.; Bachmann, M.; Kienle, A.: Analyzing the impact of heterogeneity in genetically engineered cell lines for influenza vaccine production using population balance modeling. 6th IFAC Conference on Foundations of Systems Biology in Engineering (FOSBE), Magdeburg, Germany (2016)
Poster
Laske, T.; Bachmann, M.; Frensing, T.; Reichl, U.: Model-based analysis of influenza A virus replication in genetically modified cell lines elucidates virus-host cell interactions. 17th International Conference on Systems Biology (ICSB), Barcelona, Spain (2016)
2015
Poster
Bachmann, M.; Breitwieser, T.; Lipps , C.; Wirth, D.; Jordan, I.; Rose, T.; Sandig, V.; Reichl, U.; Frensing, T.: Impaired antiviral response supports viral vaccine production in adenoviral transformed designer cell lines. 25th Annual Meeting of the Society for Virology, Bochum, Germany (2015)
Poster
Bachmann, M.; Breitwieser, T.; Lipps, C.; Wirth, D.; Jordan, I.; Rose, T.; Sandig, V.; Reichl, U.; Frensing, T.: Impaired antiviral response supports influenza vaccine production in adenoviral transformed designer cell lines. ESACT, Barcelona (2015)
2014
Poster
Bachmann, M.; Frensing, T.; Sandig, V.; Reichl, U.: Expression of adenoviral early-region E1A protein benefits cell culture-based influenza vaccine production. 4th International Influenza Meeting, Münster, Germany (2014)
Poster
Frensing, T.; Heldt, S.; Bachmann, M.; Genzel, Y.; Jordan, I.; Reichl, U.: CONTINUOUS INFLUENZA VACCINE PRODUCTION. Vaccine Technology 2014, Playa del Carmen, Mexico (2014)
Poster
Frensing, T.; Heldt, S.; Bachmann, M.; Genzel, Y.; Jordan, I.; Reichl, U.: Continuous influenza vaccine production. ProcessNet-Jahrestagung und 31. DECHEMA-Jahrestagung der Biotechnologen 2014, Aachen, Germany (2014)

Thesis - PhD (1)

2019
Thesis - PhD
Bachmann, M.: Charakterisierung der Influenzavirus-Vermehrung in genetisch veränderten humanen Zelllinien zur Optimierung der Impfstoffproduktion. Dissertation, Otto-von-Guericke-Universität, Magdeburg (2019)
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