Publications of Sascha Young Kupke

Pelz, L.; Dogra, T.; Marichal-Gallardo, P.; Hein, M. D.; Hemissi, G.; Kupke, S. Y.; Genzel, Y.; Reichl, U.: Production of antiviral “OP7 chimera” defective interfering particles free of infectious virus. Applied Microbiology and Biotechnology 108, 97 (2024)

Rüdiger, D.; Piasecka, J.; Küchler, J.; Pontes, C.; Laske, T.; Kupke, S. Y.; Reichl, U.: Mathematical model calibrated to in vitro data predicts mechanisms of antiviral action of the influenza defective interfering particle “OP7”. iScience 27 (4), 109421 (2024)

Dogra, T.; Pelz, L.; Boehme, J. D.; Küchler, J.; Kershaw, O.; Marichal-Gallardo, P.; Baelkner, M.; Hein, M. D.; Gruber, A. D.; Benndorf, D. et al.; Genzel, Y.; Bruder, D.; Kupke, S. Y.; Reichl, U.: Generation of “OP7 chimera” defective interfering influenza A particle preparations free of infectious virus that show antiviral efficacy in mice. Scientific Reports 13, 20936 (2023)

Hein, M. D.; Kazenmaier, D.; van Heuvel, Y.; Dogra, T.; Cattaneo, M.; Kupke, S. Y.; Stitz, J.; Genzel, Y.; Reichl, U.: Production of retroviral vectors in continuous high cell density culture. Applied Microbiology and Biotechnology 107, pp. 5947 - 5961 (2023)

Pelz, L.; Piagnani, E.; Marsall, P.; Wynserski, N.; Hein, M. D.; Marichal-Gallardo, P.; Kupke, S. Y.; Reichl, U.: Broad-Spectrum Antiviral Activity of Influenza A Defective Interfering Particles against Respiratory Syncytial, Yellow Fever, and Zika Virus Replication In Vitro. Viruses 15 (9), 1872 (2023)

Küchler, J.; Püttker, S.; Lahmann, P.; Genzel, Y.; Kupke, S. Y.; Benndorf, D.; Reichl, U.: Absolute quantification of viral proteins during single-round replication of MDCK suspension cells. Journal of Proteomics 259, 104544 (2022)

Hein, M. D.; Arora, P.; Marichal-Gallardo, P.; Winkler, M.; Genzel, Y.; Pöhlmann, S.; Schughart, K.; Kupke, S. Y.; Reichl, U.: Cell culture-based production and in vivo characterization of purely clonal defective interfering influenza virus particles. BMC Biology 19 (1), 91 (2021)

Hein, M. D.; Chawla, A.; Cattaneo, M.; Kupke, S. Y.; Genzel, Y.; Reichl, U.: Cell culture–based production of defective interfering influenza A virus particles in perfusion mode using an alternating tangential flow filtration system. Applied Microbiology and Biotechnology 105, pp. 7251 - 7264 (2021)

Hein, M. D.; Kollmus, H.; Marichal-Gallardo, P.; Püttker, S.; Benndorf, D.; Genzel, Y.; Schughart, K.; Kupke, S. Y.; Reichl, U.: OP7, a novel influenza A virus defective interfering particle: production, purification, and animal experiments demonstrating antiviral potential. Applied Microbiology and Biotechnology 105 (1), pp. 129 - 146 (2021)

Pelz, L.; Rüdiger, D.; Dogra, T.; Alnaji, F. G.; Genzel, Y.; Brooke, C. B.; Kupke, S. Y.; Reichl, U.: Semi-continuous propagation of influenza A virus and its defective interfering particles: analyzing the dynamic competition to select candidates for antiviral therapy. Journal of Virology 95 (24), e01174-21 (2021)

Rand, U.; Kupke, S. Y.; Shkarlet, H.; Hein, M. D.; Hirsch, T.; Marichal-Gallardo, P.; Cicin-Sain, L.; Reichl, U.; Bruder, D.: Antiviral Activity of Influenza A Virus Defective Interfering Particles against SARS-CoV-2 Replication In Vitro through Stimulation of Innate Immunity. Cells 10 (7), 1756 (2021)

Rüdiger, D.; Pelz, L.; Hein, M. D.; Kupke, S. Y.; Reichl, U.: Multiscale model of defective interfering particle replication for influenza A virus infection in animal cell culture. PLoS Computational Biology 17, e1009357 (2021)

Kupke, S. Y.; Ly, L.-H.; Börno, S. T.; Ruff, A.; Timmermann, B.; Vingron, M.; Haas , S.; Reichl, U.: Single-Cell Analysis Uncovers a Vast Diversity in Intracellular Viral Defective Interfering RNA Content Affecting the Large Cell-to-Cell Heterogeneity in Influenza A Virus Replication. Viruses 12 (1), 71 (2020)

Kupke, S. Y.; Riedel, D.; Frensing, T.; Zmora, P.; Reichl, U.: A Novel Type of Influenza A Virus-Derived Defective Interfering Particle with Nucleotide Substitutions in Its Genome. Journal of Virology 93 (4), 01786-18 (2019)

Rüdiger, D.; Kupke, S. Y.; Laske, T.; Zmora, P.; Reichl, U.: Multiscale modeling of influenza A virus replication in cell cultures predicts infection dynamics for highly different infection conditions. PLoS Computational Biology 15 (2), e1006819 (2019)

Frensing, T.; Kupke, S. Y.; Bachmann, M.; Fritzsche, S.; Gallo Ramirez, L. E.; Reichl, U.: Influenza virus intracellular replication dynamics, release kinetics, and particle morphology during propagation in MDCK cells. Applied Microbiology and Biotechnology 100 (16), pp. 7181 - 7192 (2016)

Heldt, F. S.; Kupke, S. Y.; Dorl, S.; Frensing, T.; Reichl, U.: Single-cell analysis and stochastic modelling unveil large cell-to-cell variability in influenza A virus infection. Nature Communications 6, 8938 (2015)

Rüdiger, D.; Kupke, S. Y.; Reichl, U.: A multiscale model of influenza A virus replication covering highly different infection conditions in cell cultures. IFAC-PapersOnLine 51 (19), pp. 32 - 33 (2018)

Bälkner, M.; Jeron, A.; Volckmar, J.; Pelz, L.; Dogra, T.; Kupke, S. Y.; Bruder, D.: Characterization of the local innate immune response after mucosal application of IAV Defective Interfering Particles. In European Journal of Immunology, 53 (2) Special Issue: SI Ed., P339. Joint Conference of the Société Française d'Immunologie (SFI) and the Deutsche Gesellschaft für Immunologie (DGfI), Strasbourg (France), September 26, 2023 - September 29, 2023. Wiley-VCH, Weinheim (2023)

Hein, M.; Tapia, F.; Genzel, Y.; Kupke, S. Y.; Reichl, U.: Continuous mode of production for two classes of defective interfering influenza A virus particles as antiviral candidates. In Integrated Continuous Biomanufacturing IV, 76. Biomanufact IV, Ocean Edge Resort Brewster (Cape Cod), Massachusetts, USA , October 06, 2019 - October 10, 2019. (2019)