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Journal Article (16)

1. MPG.PuRe

   DOI

   publisher-version
   Journal Article

   Kupke, S. Y.; Riedel, D.; Frensing, T.; Zmora, P.; Reichl, U.: A Novel Type of Influenza A Virus-Derived Defective Interfering Particle with Nucleotide Substitutions in Its Genome. Journal of Virology 93 (4), 01786-18 (2019)
2. MPG.PuRe

   DOI
   Journal Article

   Bachmann, M.; Breitwieser, T.; Lipps, C.; Wirth, D.; Jordan, I.; Reichl, U.; Frensing, T.: Impaired antiviral response of adenovirus-transformed cell lines supports virus replication. Journal of General Virology 97 (2), pp. 293 - 298 (2016)
3. MPG.PuRe

   DOI

   publisher-version
   Journal Article

   Frensing, T.; Kupke, S. Y.; Bachmann, M.; Fritzsche, S.; Gallo Ramirez, L. E.; Reichl, U.: Influenza virus intracellular replication dynamics, release kinetics, and particle morphology during propagation in MDCK cells. Applied Microbiology and Biotechnology 100 (16), pp. 7181 - 7192 (2016)
4. MPG.PuRe

   DOI
   Journal Article

   Laske, T.; Heldt, S.; Hoffmann, H.; Frensing, T.; Reichl, U.: Reprint of “Modeling the intracellular replication of influenza A virus in the presence of defective interfering RNAs. Virus Research 218, pp. 86 - 95 (2016)
5. MPG.PuRe

   DOI
   Journal Article

   Laske, T.; Heldt, F. S.; Hoffmann, H.; Frensing, T.; Reichl, U.: Modeling the intracellular replication of influenza A virus in the presence of defective interfering RNAs. Virus Research 213, pp. 90 - 99 (2016)
6. MPG.PuRe

   DOI
   Journal Article

   Frensing, T.: Defective interfering viruses and their impact on vaccines and viral vectors. Biotechnology Journal 10 (5), pp. 681 - 689 (2015)
7. MPG.PuRe

   DOI

   publisher-version
   Journal Article

   Heldt, F. S.; Kupke, S. Y.; Dorl, S.; Frensing, T.; Reichl, U.: Single-cell analysis and stochastic modelling unveil large cell-to-cell variability in influenza A virus infection. Nature Communications 6, 8938 (2015)
8. MPG.PuRe

   DOI

   post-print
   Journal Article

   Frensing, T.; Pflugmacher, A.; Bachmann, M.; Peschel, B.; Reichl, U.: Impact of defective interfering particles on virus replication and antiviral host response in cell culture-based influenza vaccine production. Applied Microbiology and Biotechnology 98 (21), pp. 8999 - 9008 (2014)
9. MPG.PuRe

   DOI

   publisher-version
   Journal Article

   Frensing, T.; Heldt, S.; Pflugmacher, A.; Behrendt, I.; Jordan, I.; Flockerzi, D.; Genzel, Y.; Reichl, U.: Continuous Influenza Virus Production in Cell Culture Shows a Periodic Accumulation of Defective Interfering Particles. PLoS One 8 (9), p. e72288 (2013)
10. MPG.PuRe

    DOI
    Journal Article

    Genzel, Y.; Frensing, T.; Reichl, U.: Herstellung moderner Grippeimpfstoffe: Zellkultur statt Hühnerei. Chemie in unserer Zeit 47 (1), pp. 12 - 22 (2013)
11. MPG.PuRe

    DOI

    publisher-version
    Journal Article

    Heldt, S.; Frensing, T.; Pflugmacher, A.; Gröpler, R.; Peschel, B.; Reichl, U.: Multiscale Modeling of Influenza A Virus Infection Supports the Development of Direct-Acting Antivirals. PLoS Computational Biology 9 (11), p. e1003372 (2013)
12. MPG.PuRe

    DOI
    Journal Article

    Heldt, F. S.; Frensing, T.; Reichl, U.: Modeling the intracellular dynamics of influenza virus replication to understand the control of viral RNA synthesis. Journal of Virology 86 (15), pp. 7806 - 7817 (2012)
13. MPG.PuRe

    DOI
    Journal Article

    Seitz, C.; Isken, B.; Heynisch, B.; Rettkowski, M.; Frensing, T.; Reichl, U.: Trypsin promotes efficient influenza vaccine production in MDCK cells by interfering with the antiviral host response. Applied Microbiology and Biotechnology 93 (2), pp. 601 - 611 (2012)
14. MPG.PuRe

    DOI
    Journal Article

    Frensing, T.; Seitz, C.; Heynisch, B.; Patzina, C.; Kochs, G.; Reichl, U.: Efficient influenza B virus propagation due to deficient interferon-induced antiviral activity in MDCK cells. Vaccine 29 (41), pp. 7125 - 7129 (2011)
15. MPG.PuRe

    DOI
    Journal Article

    Heynisch, B.; Frensing, T.; Heinze, K.; Seitz, C.; Genzel, Y.; Reichl, U.: Differential activation of host cell signaling pathways through infection with two variants of influenza A /Puerto Rico /8/34 (H1N1) in MDCK cells. Vaccine 28 (51), pp. 8210 - 8218 (2010)
16. MPG.PuRe

    DOI
    Journal Article

    Seitz, C.; Frensing, T.; Höper, D.; Kochs, G.; Reichl, U.: High yields of Influenza A virus in MDCK cells are promoted by an insufficient IFN-induced antiviral state. Journal of General Virology 91 (7), pp. 1754 - 1763 (2010)

Meeting Abstract (1)

1. MPG.PuRe
   Meeting Abstract

   Kupke, S. Y.; Riedel, D.; Frensing, T.; Zmora, P.; Reichl, U.: Single-cell analysis uncovers a novel influenza A virus-derived defective interfering particle for antiviral therapy. In Vaccine Technology VII, 133. Vaccine Technology VII, Mont Tremblant, Canada, June 17, 2018 - June 22, 2018. (2018)

Talk (17)

1. MPG.PuRe
   Talk

   Laske, T.; Bachmann, M.; Dostert, M.; Karlas, A.; Wirth, D.; Frensing, T.; Reichl, U.: Model-based characterization of influenza A virus production in genetically engineered cell lines elucidates changes in virus replication. 3rd Workshop on Virus Dynamics, Heidelberg, Germany (2017)
2. MPG.PuRe
   Talk

   Kupke, S. Y.; Heldt, S.; Frensing, T.; Reichl, U.: Single-Cell Analysis of Influenza A Virus-Infected Cells. 26th Annual Meeting of the Society for Virology, Münster, Germany (2016)
3. MPG.PuRe
   Talk

   Kupke, S. Y.; Heldt, S.; Frensing, T.; Reichl, U.: Heterogeneity in Influenza A Virus Infection Unveiled by Single-Cell Analysis and Stochastic Mathemeatical Modeling. Single Cell Technologies 2016, Frankfurt/Main (2016)