Head of the Group

Dr.-Ing. Steffen Klamt
Dr.-Ing. Steffen Klamt
Phone: +49 391 6110 480
Fax: +49 391 6110 509
Room: S2.10

Secretary

Susanne Hintsch
Phone:+49 391 6110-477Fax:+49 391 6110-452

News / Latest Publications

14.12.2018: New Publication
Venayak N, von Kamp A, Klamt S, Mahadevan R (2018): MoVE identifies metabolic valves to switch between phenotypic states. Nature Communications 9:5332.

07.11.2018: Björn defended his PhD thesis.
Congratulations!

28.09.2018: New Publication
Hädicke O, von Kamp A, Aydogan T, Klamt S (2018) OptMDFpathway: Identification of metabolic pathways with maximal thermodynamic driving force and its application for analyzing the endogenous CO2 fixation potential of Escherichia coli. PLoS Computational Biology 13:e1006492.

28.08.2018: New Publication
Kyselova L, Kreitmayer D, Kremling A & Bettenbrock K (2018) Type and capacity of glucose transport influences succinate yield in two-stage cultivations. Microbial Cell Factories 17:132.

10.08.2018: New Publication
Mahour R, Klapproth J, Rexer TFT, Schildbach A, Klamt S, Pietzsch M, Rapp E, Reichl U (2018) Establishment of a five-enzyme cell-free cascade for the synthesis of uridine diphosphate N-acetylglucosamine. J Biotechnol. 283:120-129.

Research

Applications of Model-Driven Metabolic Engineering

We combine computational (dry-lab; see project area 1) and genetic (wet-lab) techniques to test and establish new metabolic engineering strategies and to construct microbial cell factories for the bio-based production of selected chemicals. As relevant host organism we focus on E. coli and, more recently, also on yeast (S. cerevisiae). Research topics include:

  • Model-based metabolic engineering of E. coli for itaconic acid synthesis.
  • Model-based metabolic engineering of E. coli for synthesis of succinate.
  • Increasing the productivity of yeast (S. cerevisiae).
  • Metabolic modeling of microbial communities involved in anaerobic digestion.
  • Use of Zymomonas mobilis for synthesizing acetaldehyde.
  • Metabolic engineering strategies for cyanobacteria.
  • Design and analysis of cell-free enzymatic systems.
  • New design principles for metabolic engineering (see StrainBooster project).
  • Design of cell factories for two-stage processes based on dynamic metabolic control.

 
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