Applications of Model-Driven Metabolic Engineering

We combine computational (dry-lab; see project area 1) and genetic (wet-lab) techniques to test and establish new metabolic engineering strategies and to construct microbial cell factories for the bio-based production of selected chemicals. As relevant host organism we focus on E. coli and, more recently, also on yeast (S. cerevisiae). Research topics include:

  • Model-based metabolic engineering of E. coli for itaconic acid synthesis.
  • Model-based metabolic engineering of E. coli for synthesis of succinate.
  • Increasing the productivity of yeast (S. cerevisiae).
  • Metabolic modeling of microbial communities involved in anaerobic digestion.
  • Use of Zymomonas mobilis for synthesizing acetaldehyde.
  • Metabolic engineering strategies for cyanobacteria.
  • Design and analysis of cell-free enzymatic systems.
  • New design principles for metabolic engineering (see StrainBooster project).
  • Design of cell factories for two-stage processes based on dynamic metabolic control.

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