Programme
Updated: 04th Feb
| Time | |
|---|---|
| 08:00 | Registration |
| 09:00 |
Opening remarks
Prof. Udo Reichl (Director MPI DCTS), Thomas Rexer (eversyn & MPI DCTS) |
|
Session I:
Reshaping Biotherapeutics: Novel Approaches in Glycoprotein Modification and Production |
|
| 09:20 |
Keynote Lecture:
Nico Callewaert, VIB-UGhent Glycobiotech for immunotherapeutics: enabling new ADCs and improved CAR-T |
| 09:50 |
Erhan Citak, VIB-UGhent
Engineering of Pichia N-glycosylation pathway for improved effector functions |
| 10:10 |
Anna Behrens, GlycoEra
Rational in vivo glycoengineering of therapeutics enables generation of next level protein degraders |
| 10:30 | BREAK with Coffee, Tea & Snacks |
| 11:00 |
Charles Williams, LenioBio
Extending the eukaryotic cell-free protein synthesis toolbox with varied glycoengineering approaches |
| 11:20 |
Kerstin Otte, Biberach University of Applied Sciences
A Novel System for Glycosylation Engineering by Natural and Artificial miRNAs |
| 11:40 |
Isocani del Val, University College Dublin
Next-gen glycoengineering: Combining cellular and metabolic engineering to fine-tune mAb β1,4-galactosylation |
| 12:00 |
Björn Voldborg, DTU
Screening for optimal glycosylation on glycoproteins using glycoengineered CHO (geCHO) cells |
| 12:20 |
Lightning Talks:
Kevin Lam, Lena Tholen, Roberto Donini, Klaus Lindpaintner, Karim Jaen |
| 12:45 | LUNCH |
| 13:40 |
Panel Discussion I: The future of glycobiotechnology
Moderator: Udo Reichl |
|
Session II:
Glycoscience: From Structural Insights to Therapeutic Applications |
|
| 14:30 |
Alexander Andrew, ETH Zürich
Structural basis for the synthesis of high-mannose N-glycans in the endoplasmic reticulum |
| 14:50 |
Niels Reichardt, CIC biomaGUNE
Glycoengineering of Vectors |
| 15:10 |
Bernd Lepenies, LMU Munich
Modulation of macrophage functions by Legionella pneumophila through epigenetic reprogramming via the C-type lectin receptor Mincle |
| 15:30 | BREAK with Coffee, Tea & Snacks |
| 16:00 |
Mario Schubert, Free University of Berlin
Insights into priming and polymerizing Gram-negative group 2 capsular polysaccharides |
| 16:20 |
Martin Frank, Biognos
Glycoproteins in 3D – informatics, quality control, model building and molecular dynamics simulation |
| 16:40 |
Veronique Blanchard
The serum N-glycome to monitor response to chemotherapy in ovarian cancer patients |
| 17:00 |
Lightning Talks:
Diana Campos, Vladimir Kren, Robert Burock |
| 17:15 | Group picture |
| 17:20 | Poster Session I |
| 18:30 | DINNER |
| Time | |
|---|---|
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Session III:
Glycans & the Gut Microbiome: From Molecular Mechanisms to Biotechnological Applications |
|
| 09:00 |
Keynote Lecture:
Steven D. Townsend, Vanderbilt University tba |
| 09:30 |
Yannik Schönknecht, Novonesis
Effects of human milk oligosaccharides on human health – insights from in-vitro, in-vivo and clinical studies |
| 09:50 |
Vassilis Triantis, FrieslandCampina
Immune effects of the milk glycome |
| 10:10 |
Anne S. Meyer, DTU
New enzyme discoveries for advanced biorefining of brown seaweed polysaccharides |
| 10:30 | BREAK with Coffee, Tea & Snacks |
| 11:00 |
Keynote Lecture:
Katharina Ribbeck, MIT Leveraging Mucin Glycans to Enhance Innate Immunity |
| 11:30 |
Brigitte Zeuner, DTU
Discovery of lacto-N-biosidases and a novel N-acetyllactosaminidase activity in the CAZy family GH20: Functional diversity and structural insights |
| 11:50 |
Lucy Crouch, University of Birmingham
Breakdown of host glycans and polysaccharides by the microbiota |
| 12:10 |
Carol de Ram, Wageningen University & Research
Mucin O -glycan degradation and utilisation patterns by intestinal mucin-degrading bacteria |
| 12:30 |
Lightning Talk
: Lisa Isernhagen
Flash Pitch : MEDICAGO |
| 12:40 | LUNCH |
| 13:40 |
Panel Discussion II: The future of glycoscience
Moderator: Erdmann Rapp |
|
Session IV:
Advances & Innovations in Glycan Synthesis |
|
| 14:30 |
Kaspar Locher, ETH Zürich
An enzymatic method for in vitro production of high-mannose containing N -glycopeptides and N -glycoproteins |
| 14:50 |
Dilyara Sadykova, Imperial College
SUGAR-TARGET: A Novel Cell-Free Platform for Producing Bespoke Homogeneous Glycoprotein |
| 15:10 |
Michaela Hovorkova, Czech Academy of Sciences In vivo biotinylated tandem-repeat galectins and their carbohydrate ligands |
| 15:30 | BREAK with Coffee, Tea & Snacks |
| 16:00 |
Shubhang Sharma, Hamburg University of Technology
Continuous production of UDP-GlcNAc with a multi-enzyme reaction cascade in an enzyme membrane reactor |
| 16:20 |
Benjamin Schmitz, RWTH Aachen
Advancements in Cofactor Regeneration for Efficient Nucleotide Sugar Synthesis |
| 16:40 |
Lightning Talks:
Kai Hußnätter, Katja Pöstges, Hannes Frohnmeyer, Margot Bligh |
| 17:00 | Poster Session II |
| 18:30 | DINNER |
| Time | |
|---|---|
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Session V:
Frontiers in Glycan Analysis: Unraveling Complex Structures and Functions |
|
| 09:00 |
Anabel Torrente, Leiden University Medical Center
Comprehensive characterization of bacterial glycoconjugates vaccines by liquid chromatography – mass spectrometry |
| 09:20 |
David Falck, Leiden University Medical Center
Deep characterization of antibody responses |
| 09:40 |
Leonhard Möckl, Max Planck Institute for the Science of Light
Unraveling the functional role of the glycocalyx with highly multiplexed, molecular-resolution microscopy |
| 10:00 |
Frania Zuniga, MPI Magdeburg
Expanding Glycoproteomics: Including N Glycopeptides Bearing Glucuronidated, O Acetylated or Sulfated N Glycans in the Analysis of Human Serum Proteins such as Immunoglobulin A |
| 10:20 |
Edward Moh, Macquarie University
Glycomic flux of glycoengineered HEK293 extracellular vesicles identified using multi-glycomics |
| 10:40 | BREAK with Coffee, Tea & Snacks |
| 11:10 |
Keynote Lecture:
Manfred Wuhrer, Leiden University Medical Center Mass spectrometric studies of the glycosylation of biopharmaceuticals and patient samples |
| 11:40 |
Ahmed Ben Faleh, Isospec Analytics
A New Approach to Glycan Biomarker Discovery: Cryogenic IR Spectroscopy for Isomer-Specific Analysis |
| 12:00 |
Marcelo Guerin, Institute of Molecular Biology of Barcelona
Turning universal O into rare Bombay type blood |
| 12:20 |
Closing Remarks
Prof. Udo Reichl (Director, MPI DCTS) |