Model-based analysis of chemotherapy-induced peripheral neuropathy (CIPN)

Chemotherapy-induced peripheral neuropathy (CIPN) is a painful side effect of cancer treatment. Together with our partners from Purdue University we have studied the electrical signaling on the level of a single sensory neuron to gain a deeper understanding of the pathophysiology of pain and how this is affected by chemotherapy.

Cooperation partners

  • Prof. Ramkrishna, Purdue University
  • Prof. Yang Yang, Purdue University
  • Dr. Parul Verma, Purdue University


[1] P. Verma, A. Kienle, D. Flockerzi, and D. Ramkrishna. Using bifurcation theory for exploring pain. Ind. Eng. Chem. Res., 59:2524–2535, 2020.
[2] P. Verma, A. Kienle, D. Flockerzi, and D. Ramkrishna. Computational analysis of a 9-D model for a small DRG neuron. J. Comput. Neurosci., 2020. doi:10.1007/s10827-020-00761-6.
[3] P. Verma, M. Eaton, A. Kienle, D. Flockerzi, Y. Yang, and D. Ramkrishna. A mathematical investigation of chemotherapy-induced peripheral neuropathy. Front. Comput. Neurosci., 2020. doi: 10.3389/fncom.2020.564980.

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