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Journal Article (8)

2020
Journal Article
Gränicher, G.; Tapia, F.; Behrendt, I.; Jordan, I.; Genzel, Y.; Reichl, U.: Production of Modified Vaccinia Ankara Virus by Intensified Cell Cultures: A Comparison of Platform Technologies for Viral Vector Production. Biotechnology Journal (accepted)
2019
Journal Article
Tapia, F.; Laske, T.; Wasik, M.; Rammhold, M.; Genzel, Y.; Reichl, U.: Production of Defective Interfering Particles of Influenza A Virus in Parallel Continuous Cultures at Two Residence Times—Insights From qPCR Measurements and Viral Dynamics Modeling. Frontiers in Bioengineering and Biotechnology 7, 275 (2019)
Journal Article
Tapia, F.; Wohlfahrt, D.; Sandig, V.; Jordan, I.; Genzel, Y.; Reichl, U.: Continuous influenza virus production in a tubular bioreactor system provides stable titers and avoids the “von Magnus effect”. PLoS One 14 (11), e0224317 (2019)
2018
Journal Article
Rey-Jurado, E.; Tapia, F.; Muñoz-Durango, N.; Lay, M.K.; Carreño, L. J.; Riedel, C. A.; Bueno, S. M.; Genzel, Y.; Kalergis, A. M.: Assessing the Importance of Domestic Vaccine Manufacturing Centers: An Overview of Immunization Programs, Vaccine Manufacture, and Distribution. Frontiers in immunology 9, 26 (2018)
2017
Journal Article
Tapia, F.; Jordan, I.; Genzel, Y.; Reichl, U.: Efficient and stable production of Modified Vaccinia Ankara virus in two-stage semi-continuous and in continuous stirred tank cultivation systems. PLoS One 12 (8), e0182553 (2017)
2016
Journal Article
Tapia, F.; Vázquez-Ramirez, D.; Genzel, Y.; Reichl, U.: Bioreactors for high cell density and continuous multi-stage cultivations: options for process intensification in cell culture-based viral vaccine production. Applied Microbiology and Biotechnology 100 (5), pp. 2121 - 2132 (2016)
2014
Journal Article
Diba, M.; Goudouri, O.-M.; Tapia, F.; Boccaccini, A. R.: Magnesium-containing bioactive polycrystalline silicate-based ceramics and glass-ceramics for biomedical applications. Current Opinion in solid state & materials science 18 (3), pp. 147 - 167 (2014)
Journal Article
Tapia, F.; Vogel, T.; Genzel, Y.; Behrendt, I.; Hirschel, M.; Gangemi, J. D.; Reichl, U.: Production of high-titer human influenza A virus with adherent and suspension MDCK cells cultured in a single-use hollow fiber bioreactor. Vaccine 32 (8), pp. 1003 - 1011 (2014)

Meeting Abstract (2)

2019
Meeting Abstract
Hein, M.; Tapia, F.; Genzel, Y.; Kupke, S. Y.; Reichl, U.: Continuous mode of production for two classes of defective interfering influenza A virus particles as antiviral candidates. In Integrated Continuous Biomanufacturing IV, 76. Biomanufact IV, Ocean Edge Resort Brewster (Cape Cod), Massachusetts, USA , October 06, 2019 - October 10, 2019. (2019)
2017
Meeting Abstract
Tapia, F.; Genzel, Y.; Reichl, U.; Sandig, V.: Stirred tanks in cascades and plug-flow tubular bioreactors for continuous production of viral vaccines. In ECI Symposium Series. Integrated Continuous Biomanufacturing III, Cascais, Portugal, September 17, 2017 - September 21, 2017. (2017)

Talk (13)

2019
Talk
Laske, T.; Tapia, F.; Wasik, M.; Rammhold, M.; Genzel, Y.; Reichl, U.: Production of defective interfering particles of influenza A virus in continuously cultured bioreactors at two residence times - insights from within-host virus dynamics. 4th Workshop on Viral Dynamics, Paris, France (2019)
Talk
Nikolay, A.; Tapia, F.; Marichal-Gallardo, P.; Pralow, A.; Hoffmann, M.; Rapp, E.; Genzel, Y.; Reichl, U.: Moderne Methoden der Impfstoffherstellung. Wissenschaft im Rathaus, Magdeburg, Germany (2019)
Talk
Nikolay, A.; Tapia, F.; Marichal-Gallardo, P.; Pralow, A.; Hoffmann, M.; Rapp, E.; Genzel, Y.; Reichl, U.: Cell Culture-based Viral Vaccines: Process Intensification and Monitoring. Cuba Symposium “Frontiers of Science”, Havanna, Cuba (2019)
Talk
Reichl, U.; Vazquez-Ramirez, D.; Tapia, F.; Nikolay, A.; Genzel, Y.; Rapp, E.: Process Intensification in Viral Vaccine Manufacturing. International Symposium on Pharmaceutical Engineering Research – SPhERe, Braunschweig, Germany (2019)
Talk
Tapia, F.: A universal platform for continuous manufacturing of viral vaccines and gene therapy vectors. 5. Workshop Bio-Verfahrenstechnik, Fraunhofer CBP Leuna, Germany (2019)
Talk
Tapia, F.; Marichal-Gallardo, P.; Reichl, U.: A universal platform for continuous manufacturing of viral vaccines & gene therapy vectors. Workshop Bioverfahrenstechnik, Leuna, Germany (2019)
2017
Talk
Tapia, F.: A continuous tubular bioreactor for stable production of influenza virus vaccines. 25th ESACT Meeting, Lausanne, Switzerland (2017)
Talk
Tapia, F.: A continuous tubular bioreactor for stable production of influenza virus vaccines. CChIQ2017: National Conference of Chemical Engineering, Santiago, Chile (2017)
Talk
Tapia, F.: A continuous tubular bioreactor for stable production of influenza virus vaccines. SOMICH Coloquios de Microbiologia, Santiago, Chile (2017)
2016
Talk
Genzel, Y.; Tapia, F.; Vazquez-Ramirez, D.; Jordan, I.; Bürgin, T.; Gangemi, D. J.; Reichl, U.: Bioreactor options for continuous cell culture-derived viral vaccine production: less defective interfering particles through process intensification. BioTech 2016: Biopharmaceutical Manufacturing and Single-Use Technologies, Waedenswil, Switzerland (2016)
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