Programme

9:15

Opening remarks – Udo Reichl (Director MPI DCTS), Thomas Rexer (MPI DCTS)

9:30

Glycosciences - Fundamentals and Advances in Clinical and Biopharmaceutical Research

Chair: Marcelo Guerin (Biocruces Bizkaia Health Research Institute)

Keynote

Kaspar Locher (ETH Zurich)

Structure and mechanism of ER-luminal enzymes involved in protein glycosylation

10:10

Miloslav Sanda (Georgetown University & Max Planck Institute for Heart and Lung Research)

Glycans of the SARS-CoV ‑ 2 spike protein

10:30

Thomas Klaric (Yale School of Medicine & Genos)

Multiregional comparative N-glycomics reveals both spatial and phylogenetic gradients in mammalian brain N-glycome complexity

10:50

Ines Moreira ( Hannover Medical School)

Neolactotetraosylceramide is a novel biomarker for bladder cancer

11:10

Break. Tea & Coffee

11:40

Timm Fiebig (Hannover Medical School)

Fermentation-free and enzymes-based synthesis of vaccine antigens from Neisseria Meningitidis, Actinobacillus Pleuropneumoniae and Haemophilus Influenza

12:05

Marium Khaleque (The University of Queensland)

Differential N-Glycosylation site occupancy depends on distinct amino acid sequence features

12:25

Lightning talks (8 x 5 min):

Vladimir Kren, Pavla Bojarova, Lisa Wenzel, Olga Zaytseva , Charlotte Rossdam, Marco Albers, Brigitte-Carole Keumatio D., Roger Laine

13:05

Lunch
 

14:30

Novel Emerging & Enabling Systems in Glycobiotechnology

Chair: Mattias Collin (Lund University)

Keynote

Peter Seeberger (Max Planck Institute of Colloids and Interfaces)

Automated glycan assembly as basis for life science and material science applications

15:10

Oren Moscovitz (Max Planck Institute of Colloids and Interfaces)

Generation of glycan-specific nanobodies

15:35

Kai Hußnätter (RWTH Aachen)

Towards automated enzymatic glycan synthesis with microgel immobilized glycosyltransferases in a countercurrent flow reactor

16:00

Break. Tea & Coffee

16:30

Elli Makrydaki (Imperial College London)

SUGAR-TARGET: An immobilised enzyme cascade for targeted and bespoke glycosylation

16:50

Felix Löffler (Max Planck Institute of Colloids and Interfaces)

Parallel synthesis of glycans by vapor coupling

17:10

Lightning talks (8 x 5 min):

Hannes Frohnmeyer, Alberto Alcala, Tuan Hoang Son, Charles Williams, Myrna Bunte, Jennifer F. Alacorn, Edgar Gonzales-Rodriguez

17:50

Dine & Discuss
Poster Session

Keynote

Katja Parschat (Chr Hansen HMO)

Human milk oligosaccharides: New infant formula ingredients with diverse health benefits

9:40

Andrew McDonald (Trinity College Dublin)

Simulated symbioses: how human milk oligosaccharides influence the nascent gut microflora

10:00

Bernd Stahl (Danone Nutricia Research & Utrecht University)

Human Milk: Oligo?Saccharides and more

10:25

Sercan Karav (Canakkale Onsekiz Mart University)

Designing an in-vitro digestion model by using novel microbiome-associated enzymes to study glycan function

10:45

Break. Tea & Coffee

11:15

Nils Banke (Glycom A/S part of DSM)

Cell factory engineering and process design to make human milk oligosaccharides available to the world

11:40

Antoni Planas (University Ramon Llull)

Mechanism and engineering of Bifidobacterium Lacto-N-biosidase for type I HMO synthesis

12:00

Stephan Warnke (Ecole Polytechnique Fédérale de Lausanne)

IMS-IMS coupled to cryogenic IR spectroscopy for the identification of human milk oligosaccharides

12:20

Thomas Rexer (MPI DCTS – BPE Synthetic Biotechnology & eversyn)

Activated sugars for oligosaccharide synthesis

12:40

Lunch
 

14:15

Glycoengineering of Biopharmaceuticals

Chair: Mike Butler (NIBRT)

Keynote

Horst Bierau (Merck Serono)

Glycosylation Challenges in Biopharmaceutical Manufacturing

14:55

David Falck (Leiden University Medical Center)

PK beyond FcRn: How glycans impact pharmacokinetics of therapeutic antibodies

15:15

Marcelo Guerin (Biocruces Health Research Institute)

Sculpting therapeutic monoclonal antibody N-glycans using endoglycosidases

15:40

Break. Tea & Coffee.

16:10

Keynote

Lai-Xi Wang (University of Maryland)

Antibody glycosylation and site-specific antibody-drug conjugates

16:50

Sebastian Malik (Roche Diagnostics)

Implementation of in vitro glycoengineering of monoclonal antibodies into downstream processing

17:15

Christoph Gstöttner (Leiden University Medical Center)

Multiplexed effector function assessment of antibody glycoforms using ACE-MS

17:35

Lightning Talks (5 * 5 min):

Ioscani Jimenez del Val, Ben West, Andrea Persson, Lars Stöckl, Anna-Barbara Hachmann

18:00

Dine & Discuss
Poster Session

Keynote

Salome Pinho (University of Porto & i3S – Institute for Research and Innovation in Health)

Glycans at the frontiers of chronic inflammation, autoimmunity and cancer: mechanisms and clinical implications

9:40

Mike Butler (NIBRT)

High-throughput glycosylation profiling applied to the analysis of Covid-19 virus evolution and changes in human serum following infection

10:05

Mario Schubert (University of Salzburg)

Detection and quantification of α-Gal epitopes in intact monoclonal antibodies by NMR spectroscopy

10:25

Nathan Lewis (University of California, San Diego)

Correcting for sparsity and interdependence in glycomics to enhance discovery, diagnosis, and drug development

10:45

Lightning Talks (5 * 5 min)

Frania Zuniga-Banuelos, Friedrich Altmann, Yosra Helali, Michael Kudlich, Paras Kundalia

11:10

Break. Tea & Coffee

11:40

Kelvin Anggara (Max Planck Institute for Solid State Research)

Imaging Glycosylated Molecules One-At-A-Time

12:00

Leonhard Möckl (Max Planck Institute for the Science of Light)

Biophysics, super-resolution microscopy, and bioengineering reveal structure-function relationships in glycocalyx biology

12:20

Rene Hennig (glyXera)

Clinical glycomics for the diagnosis of congenital disorders of glycosylation

12:45

Robert Woods (Complex Carbohydrate Research Center, University of Georgia)

Glyfinder and glycoprotein builder: online tools for finding and modelling glycoproteins in the PDB

13:10

Closing remarks – Udo Reichl (Director MPI DCTS)

13:20

Lunch
End of the conference