Publications of Y. Genzel

Öncül, A.; Kalmbach, A.; Genzel, Y.; Reichl, U.; Thevenin, D.: Characterization of flow conditions in 2 L and 20 L wave bioreactors using Computational Fluid Dynamics. Biotechnology Progress 26 (1), pp. 101 - 110 (2010)

Ritter, J.; Wahl, A.; Freund, S.; Genzel, Y.; Reichl, U.: Metabolic effects of influenza virus infection in cultured animal cells: Intra- and extracellular metabolite profiling. BMC Systems Biology 4, 61 (2010)

Vester, D.; Pflugmacher, A.; Hoffmann, D.; Seitz, C.; Heldt, S.; Bettenbrock, K.; Genzel, Y.; Reichl, U.: Real-time RT-qPCR assay for the analysis of human influenza A virus transcription and replication dynamics. Journal of Virological Methods 168 (1-2), pp. 63 - 71 (2010)

Vester, D.; Rapp, E.; Kluge, S.; Genzel, Y.; Reichl, U.: Virus-host cell interactions in vaccine production cell lines infected with different human influenza A virus variants: A proteomic approach. Journal of Proteomics 73 (9), pp. 1656 - 1669 (2010)

Bock, A.; Möhler, L.; Sann, H.; Schulze-Horsel, J.; Genzel, Y.; Reichl, U.: Growth behaviour of number distributed adherent MDCK cells for optimization in large scale microcarrier cultures. Biotechnology Progress 25 (6), pp. 1717 - 1731 (2009)

Genzel, Y.; Reichl, U.: Continuous cell lines as production system for influenza vaccines. Expert Review of Vaccines 8 (12), pp. 1681 - 1692 (2009)

Lohr, V.; Rath, A.; Genzel, Y.; Jordan, I.; Sandig, V.; Reichl, U.: New avian suspension cell lines provide production of influenza virus and MVA in serum-free media: studies on growth, metabolism and virus propagation. Vaccine 27 (36), pp. 4975 - 4982 (2009)

Schulze-Horsel, J.; Schulze, M.; Agalaridis, G.; Genzel, Y.; Reichl, U.: Infection dynamics and virus-induced apoptosis in cell culture-based influenza vaccine production – flow cytometry and mathematical modeling. Vaccine 27 (20), pp. 2712 - 2722 (2009)

Schwarzer, J.; Rapp, E.; Hennig, R.; Genzel, Y.; Jordan, I.; Sandig, V.; Reichl, U.: Glycan analysis in cell culture-based influenza vaccine production: Influence of host cell line and virus strain on the glycosylation pattern of viral hemagglutinin. Vaccine 27 (32), pp. 4325 - 4336 (2009)

Vester, D.; Rapp, E.; Gade, D.; Genzel, Y.; Reichl, U.: Quantitative analysis of cellular proteome alterations in human influenza A virus-infected mammalian cell lines. Proteomics 9 (12), pp. 3316 - 3327 (2009)

Opitz, L.; Zimmermann, A.; Lehmann, S.; Genzel, Y.; Lübben, H.; Reichl, U.; Wolff, M. W.: Capture of cell culture-derived influenza virus by lectins: strain independent, but host cell dependent. Journal of Virological Methods 154 (1-2), pp. 61 - 68 (2008)

Ritter, J. B.; Genzel, Y.; Reichl, U.: Simultaneous extraction of several metabolites of energy metabolism and related substances in mammalian cells: Optimization using experimental design. Analytical Biochemistry 373, pp. 349 - 369 (2008)

Schulze-Horsel, J.; Genzel, Y.; Reichl, U.: Flow cytometric monitoring of influenza A virus infection in MDCK cells during vaccine production. BMC Biotechnology 8, 45 (2008)

Sidorenko, Y.; Wahl, A.; Dauner, M.; Genzel, Y.; Reichl, U.: Comparison of Metabolic Flux Distributions for MDCK Cell Growth in Glutamine- and Pyruvate-Containing Media. Biotechnology Progress 24 (2), pp. 311 - 320 (2008)

Wahl, A.; Sidorenko, Y.; Dauner, M.; Genzel, Y.; Reichl, U.: Metabolic flux model for an anchorage-dependent MDCK cell line: Characteristic Growth Phases and Minimum Substrate Consumption Flux Distribution. Biotechnology and Bioengineering 101 (1), pp. 135 - 152 (2008)

Hundt, B.; Best, C.; Schlawin, N.; Kassner, H.; Genzel, Y.; Reichl, U.: Establishment of a mink enteritis vaccine production process in stirred-tank reactor and Wave Bioreactor microcarrier culture in 1-10 L scale. Vaccine 25 (20), pp. 3987 - 3995 (2007)

Kalbfuss, B.; Genzel, Y.; Wolff, M. W.; Zimmermann, A.; Morenweiser, R.; Reichl, U.: Harvesting and concentration of human influenza A virus produced in serum-free mammalian cell culture for the production of vaccines. Biotechnology and Bioengineering 97 (1), pp. 73 - 85 (2007)

Genzel, Y.; Fischer, M.; Reichl, U.: Serum-free influenza virus production avoiding washing steps & medium exchange in large-scale microcarrier culture. Vaccine 24, pp. 3261 - 3272 (2006)

Genzel, Y.; Olmer, R. M.; Schäfer, B.; Reichl, U.: Wave microcarrier cultivation of MDCK cells for influenza virus production in serum containing and serum-free media. Vaccine 24 (35-36), pp. 6074 - 6087 (2006)

Ritter, J. B.; Genzel, Y.; Reichl, U.: High-performance anion-exchange chromatography using on-line electrolytic eluent generation for the determination of more than 25 intermediates from energy metabolism of mammalian cells in culture. Journal of Chromatography B 843 (2), pp. 216 - 226 (2006)