Dr.-Ing. Oliver Hädicke

Analysis and Redesign of Biological Networks
Max Planck Institute for Dynamics of Complex Technical Systems

Main Focus

  • Reconstruction and analysis of stoichiometric networks
  • Optimization of biotechnological processes
  • Analysis of 13C labeling experiments
  • Thermodynamic analyses of stoichiometric networks
  • Method development for prediction of gene knockout/overexpression candidates for rational strain design


  • Klamt S, Mahadevan R, Hädicke O (2017) When do two-stage processes outperform one-stage processes? Biotechnology Journal, PubMed

  • Klamt S, Hädicke O, Thiele S, von Kamp A (2017) Use of CellNetAnalyzer in biotechnology and metabolic engineering. Journal of Biotechnology, OpenAccess

  • Hädicke O, Klamt S (2017) EColiCore2: a reference network model of the central metabolism of Escherichia coli and relationships to its genome-scale parent model. Scientific reports, OpenAccess

  • Hädicke O, Klamt S (2015) Manipulation of the ATP pool as a tool for metabolic engineering. Biochemical Society Transactions, PubMed

  • Hädicke O, Bettenbrock K, Klamt S (2015) Enforced ATP futile cycling increases specific productivity and yield of anaerobic lactate production in Escherichia coli. Biotechnology and Bioengineering 112 (10), PubMed

  • Hädicke O, (2014) Modellbasierte Identifizierung von Interventionsstrategien für Stoffwechselnetzwerke. PhD, 182 pp. Shaker Verlag GmbH, Aachen, OpenAccess

  • Klamt S, Hädicke O, von Kamp A (2014) Stoichiometric and Constraint-Based Analysis of Biochemical Reaction Networks. Large-Scale Networks in Engineering and Life Sciences. Edited by Benner P, Findeisen R, Flockerzi D, Reichl U and Sundmacher K, Springer, pp.263-316. Springer

  • Lohr V, Hädicke O, Genzel Y, Jordan I, Buentemeyer H, Klamt S, Reichl U (2014) The avian cell line AGE1.CR.pIX characterized my metabolic flux analysis. BMC Biotechnology 14:72. Open Access

  • Gruchattka E, Hädicke O, Klamt S, Schuetz V, Kayser O (2013) In silicio profiling of Escherichia coli and Saccharomyces cerevisiae as terpenoid factories. Microbial Cell Factories 12:84. Open Access

  • Hädicke O, Lohr V, Genzel Y, Reichl U, Klamt S (2013) Evaluating differences of metabolic performances: Statistical methods and their application to animal cell cultivations. Biotechnology and Bioengineering 10: 2633-2643. PubMed

  • Carius L, Hädicke O, Grammel H (2013) Stepwise reduction of the culture redox potential allows the analysis of microaerobic metabolism and photosynthetic membrane synthesis in Rhodospirillum rubrum. Biotechnology and Bioengineering 10:573-85. PubMed

  • Hädicke O, Grammel H and Klamt S (2011) Metabolic network modeling of redox balancing and biohydrogen production in purple nonsulfur bacteria. BMC Systems Biology 5:150. Open Access

  • Hädicke O and Klamt S (2011) Computing complex metabolic intervention strategies using constrained minimal cut sets. Metabolic Engineering 13:204-213. PubMed

  • Hädicke O and Klamt S (2010) CASOP: a computational approach for strain optimization aiming at high productivity. Journal of Biotechnology 147:88-101. PubMed

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