Novel computational approaches to elucidate the topology of cellular signaling networks
Research report (imported) 2013 - Max Planck Institute for Dynamics of Complex Technical Systems
Dynamic processes in the cell are triggered and controlled by networks of interacting biomolecules, often comprising tens or hundreds of components. Although a vast amount of players (proteins, genes, metabolites) has been identified, their mutual interactions remain often hidden. Computational methods for reconstructing the topologies of cellular networks from experimental data are therefore a key research area in Systems Biology. The ARB group at the MPI in Magdeburg developed novel algorithms for biological network reconstruction and applied them successfully to realistic problems.