Dr.-Ing. Felipe Tapia

Bioprocess Engineering
Max Planck Institute for Dynamics of Complex Technical Systems
+49 391 6110 207

Main Focus

My main research interest is the development of continuous reactors for production of viruses that are relevant for vaccine and gene therapy applications.

Continuous systems are known to be more efficient than batch, but previous studies have shown that virus replication in continuous mode is limited by the accumulation of defective interfering particles (DIPs). Also, continuous virus production has the risk of unwanted viral antigenic mutations that can arise after many days of virus replication.

To solve these issues, I have been working on the production of a stable virus such as Modified Vaccinia Ankara in cascades of stirred tank bioreactors.

We have also design and constructed a novel process for influenza whole-virus production that is based on a plug-flow tubular bioreactor system. This innovation is the only bioreactor technology that enable efficient continuous production of viruses without the risk of mutations.

    Curriculum Vitae

    Higher Education:

    • M.Sc (w. Hons) in Advanced Materials and Processes, Friedrich-Alexander Universität Erlangen-Nürnberg, Germany, 2012. Focus in tissue engineering, biomaterials.
    • Diploma in Chemical Engineering, Universidad Técnica Federico Santa María, Valparaíso, Chile, 2010. Focus in process engineering.

    Publications: All publications are available in Google Scholar

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