systems are very complex. They are characterized by a great number of molecules
that interact with each other. These interactions lead to complex patterns of
regulation that influence e.g. gene expression or enzyme activities. Because of
these complex interactions and regulations, biological systems are difficult to
understand intuitively. For this reason mathematical modeling of biological
systems becomes more and more vital. The development of efficient modeling
strategies and their application for the analysis of different biological
systems, is the main focus of the group "Systems Biology". To achieve
this, molecular biological and microbiological research is combined with
mathematical modeling and the application of systems theoretical methods.
We chose to use E. coli as a
model organism because (i) E. coli represents a biologically, medically and
industrially significant organism. (ii) There are powerful experimental
techniques allowing for well controlled growth and for the generation of
reproducible and quantitative data (e.g. measurements of metabolites,
transcription and protein levels, generation of defined mutants). (iii) The
systems biology group owns experimental facilities optimally suited for the
analysis of mircoorganisms.
Starting from our first
project the analysis and mathematical modelling of Catabolite Repression in E. coli our research interests are now
1. Quantitative analysis of specific regulation and global control in E. coli
2. Model-Based modification of cellular regulation in E. coli
3. Analysis of bacterial regulations with respect to population and single cell behavior
Since 01.04.2015 I am Ombudsperson of our institute. This means that I am responsible to answer all questions and also deal with problems concerning safeguarding of "Good Scientific Practice" at our institute. Please don´t hesitate to contact me!