Targeted drug delivery: Aggregation in particle-cell systems
Research report (imported) 2010 - Max Planck Institute for Dynamics of Complex Technical Systems
To increase the efficiency of medication, carrier particles could soon deliver pharmaceutical substance exclusively to special target cells in an organism. For an understanding of these targeting processes model-based simulation studies are very helpful. The modeling of the biocolloidal systems is based on foundations from particle technology. Result: Despite substantial scattering of the experimental data, central parameters were identified. It was found that most drug targeting processes are rate limited due to the low receptor concentration on the surface of the target cells.