Targeted drug delivery: Aggregation in particle-cell systems

Research report (imported) 2010 - Max Planck Institute for Dynamics of Complex Technical Systems

Rollié, Sascha; Sundmacher, Kai
Physikalisch-Chemische Prozesstechnik
Max-Planck-Institut für Dynamik komplexer technischer Systeme, Magdeburg
To increase the efficiency of medication, carrier particles could soon deliver pharmaceutical substance exclusively to special target cells in an organism. For an understanding of these targeting processes model-based simulation studies are very helpful. The modeling of the biocolloidal systems is based on foundations from particle technology. Result: Despite substantial scattering of the experimental data, central parameters were identified. It was found that most drug targeting processes are rate limited due to the low receptor concentration on the surface of the target cells.

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