Article on Interaction Properties of the Human Rab GTPase Family recommended by Faculty1000
The article The interaction properties of the human Rab GTPase family--comparative analysis reveals determinants of molecular binding selectivity has been recommended as being of special significance in structural biology.
September 15, 2016
The article The interaction properties of the human Rab GTPase family--comparative analysis reveals determinants of molecular binding selectivity. (PLOS ONE, 2012, DOI: 10.3410/f.724162011.793522508)
has been recommended as being of special significance in structural biology.
The article has been published by the Molecular Simulations and Design Group at Max Planck Institute for Dynamics of Complex Technical Systems in cooperation with the Max Planck Institute for Molecular Cell Biology and Genetics Dresden.
"... While the sequence-based method provided important clues on Rab-specific properties, it missed the contributions of clusters of amino acid residues that are in the vicinity of each other in 3D space but not contiguous in sequence. In this recommended study, Stein et al. have focused on analyzing human Rab through combining multiple Rab data, namely their sequences, structures (generated through homology modeling), and molecular interaction fields (MIFs). ...
The methods of Stein et al. can also be applied to a similar study, but of a wider scope covering Ras superfamily members from multiple organisms, particularly to examine families of the Ras superfamily other than the Rab family"
writes F1000 Faculty Member Chandra Verma, F1000 Structural Biology, from Bioinformatics Institute, A*STAR, Singapore, Singapore.
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