Fachgruppenleiter

Dr.-Ing. Steffen Klamt
Dr.-Ing. Steffen Klamt
Telefon: +49 391 6110 480
Fax: +49 391 6110 509
Raum: S2.10

Sekretärin

Susanne Hintsch
Telefon:+49 391 6110-477Fax:+49 391 6110-452

Neuigkeiten / Letzte Publikationen

19.02.2019: CellNetAnalyzer Version 2019.1 veröffentlicht!
Neben vielen neuen Funktionalitäten gibt es auch eine neue (open-source) Lizenz für CNA. Siehe

19.02.2019: Neue Publikation
Koch S, Kohrs F, Lahmann P, Bissinger T, Wendschuh S, Benndorf D, Reichl U, Klamt S (2019) RedCom: A strategy for reduced metabolic modeling of complex microbial communities and its application for analyzing experimental datasets from anaerobic digestion. PLoS Computational Biology 15(2): e1006759.

14.12.2018: Neue Publikation
Venayak N, von Kamp A, Klamt S, Mahadevan R (2018) MoVE identifies metabolic valves to switch between phenotypic states. Nature Communications 9:5332.

07.11.2018: Björn hat seine Dissertation erfolgreich verteidigt.
Herzlichen Glückwunsch!

28.09.2018: Neue Publikation
Hädicke O, von Kamp A, Aydogan T, Klamt S (2018) OptMDFpathway: Identification of metabolic pathways with maximal thermodynamic driving force and its application for analyzing the endogenous CO2 fixation potential of Escherichia coli. PLoS Computational Biology 14:e1006492.

Analyse und Redesign biologischer Netzwerke

Steffen Klamt

Zeitschriftenartikel (80)

  1. 1.
    Zeitschriftenartikel
    Thiele, S.; Heise, S.; Hessenkemper, W.; Bongartz, H.; Fensky, M.; Schaper, F.; Klamt, S.: Designing optimal experiments to discriminate interaction graph models. IEEE ACM Transactions on Computational Biology and Bioinformatics (angenommen)
  2. 2.
    Zeitschriftenartikel
    Bosch, J.; Klamt, S.; Stoll, M.: Generalizing diffuse interface methods on graphs: non-smooth potentials and hypergraphs. SIAM Journal on Applied Mathematics 78 (3), S. 1350 - 1377 (2018)
  3. 3.
    Zeitschriftenartikel
    Hädicke, O.; Kamp von, A.; Aydogan, T.; Klamt, S.: OptMDFpathway: Identification of metabolic pathways with maximal thermodynamic driving force and its application for analyzing the endogenous CO2 fixation potential of Escherichia coli. PLoS Computational Biology 14 (9), e1006492 (2018)
  4. 4.
    Zeitschriftenartikel
    Harder, B.-J.; Bettenbrock, K.; Klamt, S.: Temperature-dependent dynamic control of the TCA cycle increases volumetric productivity of itaconic acid production by Escherichia coli. Biotechnology and Bioengineering 115 (1), S. 156 - 164 (2018)
  5. 5.
    Zeitschriftenartikel
    Klamt, S.; Mahadevan, R.; Hädicke, O.: When do two-stage processes outperform one-stage processes? Biotechnology Journal 13 (2), 1700539 (2018)
  6. 6.
    Zeitschriftenartikel
    Klamt, S.; Müller, S.; Regensburger, G.; Zanghellini, J.: A mathematical framework for yield (versus rate) optimization in constraint-based modeling and applications in metabolic engineering. Metabolic Engineering 47, S. 153 - 169 (2018)
  7. 7.
    Zeitschriftenartikel
    Mahour, R.; Klapproth, J.; Rexer, T.; Schildbach, A.; Klamt, S.; Pietzsch, M.; Rapp, E.; Reichl, U.: Establishment of a five-enzyme cell-free cascade for the synthesis of uridine diphosphate N-acetylglucosamine. Journal of Biotechnology 283, S. 120 - 129 (2018)
  8. 8.
    Zeitschriftenartikel
    Venayak, N.; Kamp von, A.; Klamt, S.; Mahadevan, R.: MoVE identifies metabolic valves to switch between phenotypic states. Nature Communications 9, 5332 (2018)
  9. 9.
    Zeitschriftenartikel
    Hädicke, O.; Klamt, S.: EColiCore2: a reference model of the central metabolism of Escherichia coli and the relationships to its genome-scale parent model. Scientific Reports 7, 39647 (2017)
  10. 10.
    Zeitschriftenartikel
    Kamp von, A.; Klamt, S.: Growth-coupled overproduction is feasible for almost all metabolites in five major production organisms. Nature Communications 8, 15926 (2017)
  11. 11.
    Zeitschriftenartikel
    Kamp von, A.; Thiele, S.; Hädicke, O.; Klamt, S.: Use of CellNetAnalyzer in biotechnology and metabolic engineering. Journal of Biotechnology 261, S. 221 - 228 (2017)
  12. 12.
    Zeitschriftenartikel
    Klamt, S.; Regensburger, G.; Gerstl, P.M.; Jungreuthmayer, C.; Schuster, S.; Mahadevan, R.; Zanghellini, J.; Müller, S.: From elementary flux modes to elementary flux vectors: Metabolic pathway analysis with arbitrary linear flux constraints. PLoS Computational Biology 13 (4), e1005409 (2017)
  13. 13.
    Zeitschriftenartikel
    Gerstl, M. P.; Klamt, S.; Jungreuthmayer, C.; Zanghellini, J.: Exact quantification of cellular robustness in genome-scale metabolic networks. Bioinformatics 32 (5), S. 730 - 737 (2016)
  14. 14.
    Zeitschriftenartikel
    Harder, B.-J.; Bettenbrock, K.; Klamt, S.: Model-Based metabolic engineering enables high yield itaconic acid production by Escherichia coli. Metabolic Engineering 38, S. 29 - 37 (2016)
  15. 15.
    Zeitschriftenartikel
    Koch, S.; Benndorf, D.; Fronk, K.; Reichl, U.; Klamt, S.: Predicting compositions of microbial communities from stoichiometric models with applications for the biogas process. Biotechnology for Biofuels 9, 17 (2016)
  16. 16.
    Zeitschriftenartikel
    Ud-Dean, S.; Heise, S.; Klamt, S.; Gunawan, R.: TRaCE+: Ensemble inference of gene regulatory networks from transcriptional expression profiles of gene knock-out experiments. BMC Bioinformatics 17 (17), 252 (2016)
  17. 17.
    Zeitschriftenartikel
    Wu, H.; Kamp von, A.; Leoncikas, V.; Mori, W.; Sahin, M.; Gevorgyan, A.; Linley, C.; Grabowski, M.; Mannan, A. A.; Stoy, N. et al.; Steward, G. R.; Ward, L. T.; Lewis, D.J.M.; Sroca, J.; Matsuno, H.; Klamt, S.; Westerhoff, H.V.; McFadden, J.; Plant, N.J.; Kierzek, A.M.: MUFINS: multi-formalism interaction network simulator. npj Systems Biology and Applications 2, 16032 (2016)
  18. 18.
    Zeitschriftenartikel
    Bastiaens, P. I.H.; Birtwistle, M.; Blüthgen, N.; Bruggeman, F.; Cho, K.-H.; de la Fuente, A.; Hoek, J.; Kiyatkin, A.; Klamt, S.; Kolch, W. et al.; Legewie, S.; Mendes, P.; Naka, T.; Santra, T.; Sontag, E.; Westerhoff, H.; Kholodenko, B.: Silence on the relevant literature and errors in implementation. Nature Biotechnology 33 (4), S. 336 - 339 (2015)
  19. 19.
    Zeitschriftenartikel
    D`Allessandro, L. A.; Samaga, R.; Maiwald, T.; Rho, S.-H.; Bonefas, S.; Raue, A.; Iwamoto, N.; Kienast, A.; Waldow, K.; Meyer, R. et al.; Schilling, M.; Timmer, J.; Klamt, S.; Klingmüller, U.: Disentangling the Complexity of HGF Signaling by Combining Qualitative and Quantitative Modeling. PLoS Computational Biology 11 (4), e1004192 (2015)
  20. 20.
    Zeitschriftenartikel
    Erdrich, P.; Steuer, R.; Klamt, S.: An algorithm for the reduction of genome-scale metabolic network models to meaningful core models. BMC Systems Biology 9, 48 (2015)
  21. 21.
    Zeitschriftenartikel
    Hädicke, O.; Klamt, S.: Manipulation of the ATP pool as a tool for metabolic engineering. Biochemical Society Transactions (London) 43 (6), S. 1140 - 1145 (2015)
  22. 22.
    Zeitschriftenartikel
    Hädicke, O.; Bettenbrock, K.; Klamt, S.: Enforced ATP futile cycling increases specific productivity and yield of anaerobic lactate production in Escherichia coli. Biotechnology and Bioengineering 112 (10), S. 2195 - 2199 (2015)
  23. 23.
    Zeitschriftenartikel
    Klamt, S.; Mahadevan, R.: On the feasibility of growth-coupled product synthesis in microbial strains. Metabolic Engineering 30, S. 166 - 178 (2015)
  24. 24.
    Zeitschriftenartikel
    Mahadevan, R.; Kamp von, A.; Klamt, S.: Genome-scale strain designs based on regulatory minimal cut sets. Bioinformatics 31 (17), S. 2844 - 2851 (2015)
  25. 25.
    Zeitschriftenartikel
    Michailidou, M.; Melas, I.; Messinis, D.; Klamt, S.; Alexopoulos, L.; Kolisis, F.; Loutrari, H.: Network-Based Analysis of Nutraceuticals in Human Hepatocellular Carcinomas Reveals Mechanisms of Chemopreventive Action. CPT: Pharmacometrics & Systems Pharmacology 4 (6), S. 350 - 361 (2015)
  26. 26.
    Zeitschriftenartikel
    Mueller, S.; Huard, J.; Waldow, K.; Huang, X.; D'Alessandro, L.; Bohl, S.; Börner, K.; Grimm, D.; Klamt, S.; Klingmüller, U. et al.; Schilling, M.: T160‐phosphorylated CDK2 defines threshold for HGF‐dependent proliferation in primary hepatocytes. Molecular Systems Biology 11, 795 (2015)
  27. 27.
    Zeitschriftenartikel
    Thiele, S.; Cerone, L.; Saez-Rodriguez, J.; Siegel, A.; Guciolowski, C.; Klamt, S.: Extended notions of sign consistency to relate experimental data to signaling and regulatory network topologies. BMC Bioinformatics 16 (1), 345 (2015)
  28. 28.
    Zeitschriftenartikel
    Wiechert, W.; Klamt, S.: Computational Systems Biology — neues Fach in den Lebenswissenschaften. Biospektrum 21 (1), S. 46 - 48 (2015)
  29. 29.
    Zeitschriftenartikel
    Erdrich, P.; Knoop, H.; Steuer, R.; Klamt, S.: Cyanobacterial biofuels: new insights and strain design strategies revealed by computational modeling. Microbial Cell Factories 13, S. 128 - 128 (2014)
  30. 30.
    Zeitschriftenartikel
    Kamp von, A.; Klamt, S.: Enumeration of Smallest Intervention Strategies in Genome-Scale Metabolic Networks. PLoS Computational Biology 10 (1), e1003378 (2014)
  31. 31.
    Zeitschriftenartikel
    Lohr, V.; Hädicke, O.; Genzel, Y.; Jordan, I.; Buentemeyer, H.; Klamt, S.; Reichl, U.: The avian cell line AGE1.CR.pIX characterized by metabolic flux analysis. BMC Biotechnology 14, S. 72 (2014)
  32. 32.
    Zeitschriftenartikel
    Ryll, A.; Bucher, J.; Bonin, A.; Bongard, S.; Gonçalves , E.; Saez- Roidriguez, J.; Niklas, J.; Klamt, S.: A model integration approach linking signalling and gene-regulatory logic with kinetic metabolic models. Biosystems 124, S. 26 - 38 (2014)
  33. 33.
    Zeitschriftenartikel
    Chaoiya, C.; Berenguier, D.; Keating, S. M.; Naldi, A.; van Iersel, M. P.; Rodriguez, N.; Dräger, A.; Büchel, F.; Cokelaer, T.; Kowal, B. et al.; Wicks, B.; Gonçalves, E.; Dorier, J.; Page, M.; Monteiro, P. T.; Kamp von, A.; Xenarius , I.; de Jong, H.; Hucka, M.; Klamt, S.; Thieffrey, D.; Le Novère, N.; Saez-Rodriguez, J.; Helikar, T.: SBML qualitative models: a model representation format and infrastructure to foster interactions between qualitative modelling formlisms and tools. BMC Systems Biology 7, S. 135 (2013)
  34. 34.
    Zeitschriftenartikel
    Flassig, R.; Heise, S.; Sundmacher, K.; Klamt, S.: An effective framework for reconstructing gene regulatory networks from genetical genomics data. Bioinformatics 29 (2), S. 246 - 254 (2013)
  35. 35.
    Zeitschriftenartikel
    Gonçalves, E.; Bucher, J.; Ryll, A.; Niklas, J.; Mauch, K.; Klamt, S.; Rocha, M.; Saez-Rodriguez, J.: Bridging the layers: towards integration of signal transduction, regulation and metabolism into mathematical models. Molecular BioSystems 9 (7), S. 1576 - 1583 (2013)
  36. 36.
    Zeitschriftenartikel
    Gruchattka, E.; Hädicke, O.; Klamt, S.; Schuetz, V.; Kayser , O.: In silico profiling of Escherichia coli and Saccharomyces cerevisiae as terpenoid factories. Microbial Cell Factories 12, 84 (2013)
  37. 37.
    Zeitschriftenartikel
    Hädicke, O.; Lohr, V.; Genzel, Y.; Reichl, U.; Klamt, S.: Evaluating differences of metabolic performances: Statistical methods and their application to animal cell cultivations. Biotechnology and Bioengineering 110 (10), S. 2633 - 2642 (2013)
  38. 38.
    Zeitschriftenartikel
    Jungreuthmeyer, C.; Nair, G.; Klamt, S.; Zanghellini, J.: Comparison and improvement of algorithms for computing minimal cut sets. BMC Bioinformatics 14 (1), S. 318 (2013)
  39. 39.
    Zeitschriftenartikel
    Melas, I. N.; Samaga, R.; Alexopoulos, L. G.; Klamt, S.: Detecting and Removing Inconsistencies between Experimental Data and Signaling Network Topologies Using Integer Linear Programming on Interaction Graphs. PLoS Computational Biology 9 (9), S. e1003204 (2013)
  40. 40.
    Zeitschriftenartikel
    Pinna, A.; Heise, S.; Flassig, R.; de la Fuente, A.; Klamt, S.: Reconstruction of large-scale regulatory networks based on perturbation graphs and transitive reduction: improved methods and their evaluation. BMC Systems Biology 7, S. 73 (2013)
  41. 41.
    Zeitschriftenartikel
    Samaga, R.; Klamt, S.: Modeling approaches for qualitative and semi-quantitative analysis of cellular signaling networks. Cell Communication and Signaling 11 (1), S. 43 (2013)
  42. 42.
    Zeitschriftenartikel
    Ballerstein, K.; von Kamp, A.; Klamt, S.; Haus, U.-U.: Minimal cut sets in metabolic networks are elementary modes in a dual network. Bioinformatics 28 (3), S. 381 - 387 (2012)
  43. 43.
    Zeitschriftenartikel
    Huard, J.; Mueller, S.; Gilles, E. D.; Klingmüller, U.; Klamt, S.: An integrative model links multiple inputs and signaling pathways to the onset of DNA synthesis in hepatocytes. FEBS Journal 279 (18), S. 3290 - 3313 (2012)
  44. 44.
    Zeitschriftenartikel
    Hädicke, O.; Klamt, S.: Computing complex metabolic intervention strategies using constrained minimal cut sets. Metabolic Engineering 13 (2), S. 204 - 213 (2011)
  45. 45.
    Zeitschriftenartikel
    Hädicke, O.; Grammel, H.; Klamt, S.: Metabolic network modeling of redox balancing and biohydrogen production in purple nonsulfur bacteria. BMC Systems Biology 5, S. 150 (2011)
  46. 46.
    Zeitschriftenartikel
    Klamt, S.; Kamp von, A.: An application programming interface for CellNetAnalyzer. Biosystems 105 (2), S. 162 - 168 (2011)
  47. 47.
    Zeitschriftenartikel
    Ryll, A.; Samaga, R.; Schaper, F.; Alexopoulos, L.G.; Klamt, S.: Large-scale models of IL-1 and IL-6 signaling and their hepatocellular specification. Molecular BioSystems 7 (12), S. 3253 - 3270 (2011)
  48. 48.
    Zeitschriftenartikel
    Franke, R.; Theis, F.J.; Klamt, S.: From Binary to Multivalued to Continuous Models: The Iac Operon as a Case Study. Journal of Integrative Bioinformatics 7 (1), S. 151 (2010)
  49. 49.
    Zeitschriftenartikel
    Hädicke, O.; Klamt, S.: CASOP: a computational approach for strain optimization aiming at high productivity. Journal of Biotechnology 147 (2), S. 88 - 101 (2010)
  50. 50.
    Zeitschriftenartikel
    Klamt, S.; Flassig, R.; Sundmacher, K.: TRANSWESD: inferring cellular networks with transitive reduction. Bioinformatics 26 (17), S. 2160 - 2168 (2010)
  51. 51.
    Zeitschriftenartikel
    Samaga, R.; von Kamp, A.; Klamt, S.: Computing Combinatorial Intervention Strategies and Failure Modes in Signaling Networks. Journal of Computational Biology 17 (1), S. 39 - 53 (2010)
  52. 52.
    Zeitschriftenartikel
    Klamt, S.; von Kamp, A.: Computing Paths and Cycles in Biological Interaction Graphs. BMC Bioinformatics 10, S. 181 (2009)
  53. 53.
    Zeitschriftenartikel
    Klamt, S.; Haus, U.-U.; Theis, F.: Hypergraphs and cellular networks. PLoS Computational Biology 5 (5), S. e1000385 (2009)
  54. 54.
    Zeitschriftenartikel
    Poltz, R.; Franke, R.; Schweitzer, K.; Klamt, S.; Gilles, E. D.; Naumann, M.: Logical network of genotoxic stress-induced NF-kB signal transduction predicts putative target structures for therapeutic intervention strategies. Advances and Applications in Bioinformatics and Chemistry 2, S. 125 - 138 (2009)
  55. 55.
    Zeitschriftenartikel
    Saez-Rodriguez, J.; Alexopoulos, L. G.; Epperlein, J.; Samaga, R.; Lauffenburger, D. A.; Klamt, S.; Sorger, P. K.: Discrete logic modelling as a means to link protein signalling networks with functional analysis of mammalian signal transduction. Molecular Systems Biology 5, S. 331 (2009)
  56. 56.
    Zeitschriftenartikel
    Samaga, R.; Saez-Rodriguez, J.; Alexopoulos, L. G.; Sorger, P. K.; Klamt, S.: The logic of EGFR/ErbB signaling: theoretical properties and analysis of high-throughput data. PLoS Computational Biology 5 (8), e1000438 (2009)
  57. 57.
    Zeitschriftenartikel
    Wittmann, D. M.; Krumsiek, J.; Saez, J.; Lauffenburger, D. A.; Klamt, S.; Theis, F.: Transforming Boolean models to continuous models: methodology and application to T-cell receptor signaling. BMC Systems Biology 3, 98 (2009)
  58. 58.
    Zeitschriftenartikel
    Franke, R.; Mueller, M.; Wundrack, N.; Gilles, E. D.; Klamt, S.; Kaehne, T.; Naumann, M.: Host-pathogen systems biology: Logical modelling of hepatocyte growth factor and Helicobacter pylori induced c-Met signal transduction. BMC Systems Biology 2, 4 (2008)
  59. 59.
    Zeitschriftenartikel
    Haus, U.-U.; Klamt, S.; Stephen, T.: Computing knock-out strategies in metabolic networks. Journal of Computational Biology 15 (3), S. 259 - 268 (2008)
  60. 60.
    Zeitschriftenartikel
    Klamt, S.; Grammel, H.; Straube, R.; Ghosh, R.; Gilles, E. D.: Modeling the electron transport chain of purple non-sulfur bacteria. Molecular Systems Biology 4, 156 (2008)
  61. 61.
    Zeitschriftenartikel
    Saez-Rodriguez, J.; Hammerle-Fickinger, A.; Dalal, O.; Klamt, S.; Gilles, E. D.; Conradi, C.: Multistability of signal transduction motifs. IET Systems Biology 2 (2), S. 80 - 93 (2008)
  62. 62.
    Zeitschriftenartikel
    Beste, D. J.; Hooper, T.; Stewart, G.; Bonde, B.; Avignone-Rossa, C.; Bushell, M. E.; Wheeler, P.; Klamt, S.; Kierzek, A. M.; McFadden, J.: GSMN-TB: a web-based genome-scale network model of Mycobacterium tuberculosis metabolism. Genome Biology 8, R89 (2007)
  63. 63.
    Zeitschriftenartikel
    Klamt, S.; Saez-Rodriguez, J.; Gilles, E. D.: Structural and functional analysis of cellular networks with CellNetAnalyzer. BMC Systems Biology 1, 2 (2007)
  64. 64.
    Zeitschriftenartikel
    Saez-Rodriguez, J.; Simeoni, L.; Lindquist, J.; Hemenway, R.; Bommhardt, U.; Arndt, B.; Haus, U. U.; Weismantel, R.; Gilles, E. D.; Klamt, S. et al.; Schraven, B.: A logical model provides insights into T cell receptor signaling. PLoS Computational Biology 3, e163 (2007)
  65. 65.
    Zeitschriftenartikel
    Klamt, S.: Generalized concept of minimal cut sets in biochmical networks. Biosystems 83 (2-3 ), S. 233 - 247 (2006)
  66. 66.
    Zeitschriftenartikel
    Klamt, S.; Saez-Rodriguez, J.; Lindquist, J.; Simeoni, L.; Gilles, E. D.: A methodology for the structural and functional analysis of signaling and regulatory networks. BMC Bioinformatics 7, S. 56 (2006)
  67. 67.
    Zeitschriftenartikel
    Saez-Rodriguez, J.; Mirschel, S.; Hemenway, R.; Klamt, S.; Gilles, E. D.; Ginkel, M.: Visual set-up of logical models of signaling and regulatory networks with ProMoT. BMC Bioinformatics 7, 506 (2006)
  68. 68.
    Zeitschriftenartikel
    Klamt, S.; Gagneur, J.; von Kamp, A.: Algorithmic approaches for computing elementary modes in large biochemical reaction networks. IEE Proceedings - Systems Biology 152 (4), S. 249 - 255 (2005)
  69. 69.
    Zeitschriftenartikel
    Gagneur, J.; Klamt, S.: Computation of elementary modes: a unifying framework and the new binary approach. BMC Bioinformatics 5, 175 (2004)
  70. 70.
    Zeitschriftenartikel
    Klamt, S.; Gilles, E. D.: Minimal cut sets in biochemical reaction networks. Bioinformatics 20, S. 226 - 234 (2004)
  71. 71.
    Zeitschriftenartikel
    Kremling, A.; Ginkel, M.; Klamt, S.; Gilles, E. D.: Workbench zur Modellbildung, Simulation und Analyse zellulärer Systeme. it - Information Technology 46, S. 12 - 19 (2004)
  72. 72.
    Zeitschriftenartikel
    Papin, J. A.; Stelling, J.; Price, N. D.; Klamt, S.; Schuster, S.; Palsson, B. O.: Comparison of network-based pathway analysis methods. Trends in Biotechnology 22 (8), S. 400 - 405 (2004)
  73. 73.
    Zeitschriftenartikel
    Klamt, S.; Stelling, J.: Two approaches for metabolic pathway analysis? Trends in Biotechnology 21 (2), S. 64 - 69 (2003)
  74. 74.
    Zeitschriftenartikel
    Klamt, S.; Stelling, J.; Ginkel, M.; Gilles, E. D.: FluxAnalyzer: exploring structure, pathways, and flux distributions in metabolic networks on interactive flux maps. Bioinformatics 19 (2), S. 261 - 269 (2003)
  75. 75.
    Zeitschriftenartikel
    Klamt, S.; Schuster, S.; Gilles, E. D.: Calculability analysis in underdetermined metabolic networks illustrated by a model of the central metabolism in purple nonsulfur bacteria. Biotechnology and Bioengineering 77 (7), S. 734 - 751 (2002)
  76. 76.
    Zeitschriftenartikel
    Klamt, S.; Stelling, J.: Combinatorial complexity of pathway analysis in metabolic networks. Molecular Biology Reports 29 (1-2), S. 233 - 236 (2002)
  77. 77.
    Zeitschriftenartikel
    Klamt, S.; Schuster, S.: Calculating as many fluxes as possible in underdetermined metabolic networks. Molecular Biology Reports 29 (1-2), S. 243 - 248 (2002)
  78. 78.
    Zeitschriftenartikel
    Schuster, S.; Klamt, S.; Weckwerth, W.; Moldenhauer, F.; Pfeiffer, T.: Use of network analysis of metabolic systems in bioengineering. Bioprocess and Biosystems Engineering 24 (6), S. 363 - 372 (2002)
  79. 79.
    Zeitschriftenartikel
    Schuster, S.; Klamt, S.: Applying metabolic pathway analysis to make good use of methanol. Trends in Biotechnology 20 (8), S. 322 (2002)
  80. 80.
    Zeitschriftenartikel
    Stelling, J.; Klamt, S.; Bettenbrock, K.; Schuster, S.; Gilles, E. D.: Metabolic network structure determines key aspects of functionality and regulation. Nature 420 (6912), S. 190 - 193 (2002)

Buchkapitel (3)

  1. 81.
    Buchkapitel
    Klamt, S.; Haedicke, O.; von Kamp, A.: Stoichiometric and Constraint-Based Analysis of Biochemical Reaction Networks. In: Large-Scale Networks in Engineering and Life Sciences, S. 263 - 316. Springer International Publishing, Cham (2014)
  2. 82.
    Buchkapitel
    Heise, S.; Flassig, R.; Klamt, S.: Benchmarking a Simple Yet Effective Approach for Inferring Gene Regulatory Networks from Systems Genetic Data. In: Gene Network Inference: Verification of Methods for Systems Genetic Data., S. 33 - 47. Springer, Heidelberg (2013)
  3. 83.
    Buchkapitel
    Waddell, S. J.; Kamp von, A.; Klamt, S.; Neyrolles, O.: Host-pathogen interactions. In: Systems Biology of Tuberculosis, S. 107 - 126. Springer, New York (2013)

Konferenzbeitrag (3)

  1. 84.
    Konferenzbeitrag
    Ryll, A.; Bucher, J.; Niklas , J.; Klamt, S.: A fusion approach linking signaling logic and metabolic mass-flow kinetics in hepatocytes. In: Computational Methods in Systems Biology: 11th International Conference, CMSB 2013, S. 255 - 256. 11th International Conference on Computational Methods in Systems Biology CMSB 13, Klosterneuburg, Austria, 22. September 2013 - 24. September 2013. (2013)
  2. 85.
    Konferenzbeitrag
    Bohl, K.; Figueiredo, L.F.; Hädicke, O.; Klamt, S.; Kost, C.; Schuster, S.; Kaleta, C.: CASOP GS: Computing intervention strategies targeted at production improvement in genome-scale metabolic networks. In: German Conference on Bioinformatics 2010, S. 71 - 80 (Hg. Schomburg, D.; Grote, A.). German Conference on Bioinformatics 2010, Braunschweig, Germany, 20. September 2010 - 22. September 2010. (2010)
  3. 86.
    Konferenzbeitrag
    Klamt, S.; Kremling, A.; Gilles, E. D.: FluxAnalyzer: a graphical user interface for stoichiometric and quantitative analysis of metabolic networks. 8th IFAC Internationall Conference on Computer Applications in Biotechnology, Québec, 24. Juni 2001 - 27. Juni 2001. IFAC Proceedings Volumes, S. 119 - 124 (2001)

Vortrag (4)

  1. 87.
    Vortrag
    Harder, B.-J.; Bettenbrock, K.; Klamt, S.: Model-based Metabolic Engineering of Escherichia coli for high yield itaconic acid production. Himmelfahrtstagung "Models for Developing and Optimising Biotech Production", Neu-Ulm, Germany (2017)
  2. 88.
    Vortrag
    Harder, B.-J.; Bettenbrock, K.; Klamt, S.: Model-based Metabolic Engineering of Escherichia coli for high yield itaconic acid production. Systems Biology meets Synthetic Biology, Frankfurt am Main, Germany (2017)
  3. 89.
    Vortrag
    Harder, B.-J.; Bettenbrock, K.; Klamt, S.: Model-based Metabolic Engineering of Escherichia coli for high yield itaconic acid production. Annual Conference 2016 of the Association for General and Applied Microbiology (VAAM), Jena, Germany (2016)
  4. 90.
    Vortrag
    Koch, S.; Benndorf, D.; Reichl, U.; Klamt, S.: Predicting compositions of microbial communities from stoichiometric models with applications for the biogas process. Annual Conference 2016 of the Association for General and Applied Microbiology (VAAM), Jena, Germany (2016)

Poster (6)

  1. 91.
    Poster
    Koch, S.; Benndorf, D.; Kohrs, F.; Lahmann, P.; Reichl, U.; Klamt, S.: Strategies for Modeling of Large-Scale Metabolic Models of Microbial Communities. Metabolic Pathway Analysis 2017, Bozeman, Montana, USA (2017)
  2. 92.
    Poster
    Harder, B.-J.; Bettenbrock, K.; Klamt, S.: Model-Based Metabolic Engineering of Escherichia Coli for High Yield Itaconic Acid Production. 6th International Conference on Foundations of Systems Biology in Engineering, Magdeburg, Germany (2016)
  3. 93.
    Poster
    Harder, B.-J.; Bettenbrock, K.; Klamt, S.: Model-Based Metabolic Engineering of Escherichia coli for High Yield Itaconic Acid Production. Metabolic Engineering 11, Kobe, Japan (2016)
  4. 94.
    Poster
    Koch, S.; Benndorf, D.; Reichl, U.; Klamt, S.: New Methods for Modeling of Microbial Communities with Stoichiometric Metabolic Models. 6th International Conference on Foundations of Systems Biology in Engineering, Magdeburg, Germany (2016)
  5. 95.
    Poster
    Koch, S.; Benndorf, D.; Reichl, U.; Klamt, S.: Prediction of Community Compositions in Stoichiometric Community Models. 4th Conference on Constraint-Based Reconstruction and Analysis, Heidelberg, Germany (2015)
  6. 96.
    Poster
    Flassig, R.; Heise, S.; Sundmacher, K.; Klamt, S.: An effective Framework for Gene RegulatoryNetwork Reconstruction from Genetical Genomics Data. GCB 2012, Jena, Germany (2012)

Hochschulschrift - Doktorarbeit (1)

  1. 97.
    Hochschulschrift - Doktorarbeit
    Klamt, S.: Strukturelle Analyse von Stoffwechselnetzen illustriert am bakteriellen Redox- und Zentralstoffwechsel. Dissertation, 194 S., Shaker, Aachen (2005)

Heft (1)

  1. 98.
    Heft
    Schuster, S.; Kaleta, C.; Klamt, S.; Figueiredo de, L.F. (Hg.): Proceedings of the workshop "Integration of OMICs datasets into metabolic pathway analysis" Edingburgh, U.K., 15 October 2010 IOMPA 2010 (Sonderheft). (2011)

Editorial (1)

  1. 99.
    Editorial
    Kaleta, C.; de Figueiredo, L. F.; Heiland, I.; Klamt, S.; Schuster, S.: Special Issue: Integration of OMICs datasets into Metabolic Pathway Analysis. Biosystems 105 (2), S. 107 - 108 (2011)
 
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